摘要:

SUMMARYThe present study concerns eighteen chronic alcoholics with minimal liver damage. A significant reduction in total serum T4 with an accompanying drop in circulating TBG was observed in these otherwise euthyroid patients. During alcohol withdrawal, we observed a rapid increase in T4 and TBG into the normal range. We suggest that the fall in the level of circulating thyroxine‐binding globulin is related to a defect in its synthesis or secretion by the liver due to ethanol consumption. Caution is recommended in the interpretation of thyroid function tests in chronic alcoholic

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1981.tb00605.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYSerum T4, 3,5,3′‐triiodothyronine (T3), 3,3′,5′‐triiodothyronine (reverse T3, rT3), 3,3′‐diiodothyronine (3,3′‐T2), 3′,5′‐diiodothyronine (3′,5′‐T2) and thyrotrophin (TSH) levels were studied in nineteen obese patients before and 6, 12, and 18, months after a jejuno‐ileal bypass. Before surgery, the obese patients had increased serum T3 levels compared with a group of lean, matched controls (median: 1·94 nmol/1 v. 1·44 nmol/l,P<0·01). Serum T3 decreased to normal (1·64 nmol/l) 18 months after surgery. A slight decrease was also observed in serum 3,3′‐T2 levels, whereas progressive reductions in serum concentrations of rT3 and 3′,5′T2 occurred. Eighteen months postoperatively the serum levels of rT3 and 3′,5′‐T2 had decreased from 0·676 nmol/l to 0·430 nmol/l (P<0·02) and 55–2 pmol/l to 40.0 pmol/l (P<0·01), respectively, and the values at 18 months were also reduced compared with the control group [0·722 nmol rT3/1 (P<0·01), 51·4 pmol 3′,5′‐T2/1 (P<0·01)]. Concomitant with the decrease in serum levels of the iodothyronines, seru

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1981.tb00606.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYHigh gastrin levels were found in twenty‐one out of fifty‐six consecutive patients (38%) with thyrotoxicosis. Following return to euthyroidism gastrin levels generally fell, but twelve patients (21%) remained hypergastrinaemic. Six of these patients (11%) had achlorhydria indicating atrophic gastritis of the antrum sparing type. No correlation between gastrin and triiodothyronine values was found. It is suggested that gastrin levels should be measured in thyrotoxic patients after treatment, and further control instituted in patients with raised gastrin levels. The relationship between gastric function, gastrin release and thyroid function seems complex. The interactions may involve both a direct effect of thyroid hormone on gastric acid production, adrenergic influences on gastrin release and linked phenomena with development of thyroid and gastric auto‐immune dis

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1981.tb00607.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYThis study was carried out to test the hypothesis that sustained hyperprolactinaemia in patients with prolactinomas stimulates hypothalamic dopaminergic activity via a short loop positive feedback effect of prolactin (PRL). The intensity of dopamine (DA) effects on the pituitary around the adenoma was evaluated by measuring thyroid stimulating hormone (TSH) responses to intravenous injection of domperidone (10 mg) a new DA receptor blocking drug that does not penetrate the blood‐brain barrier. TSH responses have been compared with those of PRL to the same agent. Eight females with prolactinomas showed greater TSH release after domperidone than nine normal females (sum of TSH increments over 120 min 17·5 ± 1·7 v. 8·9±1·5 mu/l,P<0·001) whilst PRL release was reduced (sum of PRL increments over 120 min 5·9 ± 2·4 v. 21·8 ± 3·8 mu/l ± 10−3,P<0·01). Amongst nineteen hyperprolactinaemic females with apparently normal pituitary fossae (plain skull X‐ray), ten showed an exaggerated TSH response (ΔTSH, 4·2 ± 0·6 mu/l, range 2·5–9·40 mu/l) and reduced PRL response to domperidone, comparable with established tumour cases. In the remaining nine normal fossa hyperprolactinaemic females, the TSH and PRL responses to domperidone were similar to normal females.These results support the initial hypothesis and indicate the coexistence of a defect in the dopaminergic inhibition of PRL release and increased dopaminergic inhibition of TSH release in patients with prolactinomas. The presence of an exaggerated TSH response to DA antagonism in a euthyroid, radiologically normal (plain skull X‐ray), hyperprolactinaemic patient is compatible with the presence of an autonomously‐functioning, PRL secreting, pituitary microadenoma and the TSH changes seen in these patients after DA antagonist administration can be readily detected b

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1981.tb00608.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYSevere hypercholesterolaemia in a 17‐year‐old girl was found to be due to the coexistence of heterozygous familial hypercholesterolaemia and chronic lymphocytic thyroiditis with primary hypothyroidism. Her cultured skin fibroblasts showed a 70–75% reduction in the binding, internalization and degradation of125I‐labelled low density lipoprotein and several other family members were hypercholesterolaemic. Replacement therapy with L‐thyroxine reduced the concentrations of total and low density lipoprotein cholesterol and apoprotein B in the patient's plasma to values similar to those in other sibs with only heterozygous familial hypercholesterolaemia. Severe hypercholesterolaemia attributable to coexistent heterozygous familial hypercholesterolaemia and hypothyroidism in teenage girls may be estimated to occur with a frequency of between 1 in 500 000 and 1 in 106. This value is similar to the gene frequency for homozygous familial hypercholest

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1981.tb00609.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYSerum antibodies against human, bovine, and guinea‐pig, orbital antigens were tested for in patients with Graves' ophthalmopathy using haemagglutination and immunofluorescence techniques. Although low titres of antibodies were demonstrated in a small proportion of patients with Graves' ophthalmopathy, the prevalence was similar to that for normal subjects using both tests. The significance of these findings and the evidence for a role of autoantibodies in the pathogenesis of Graves' ophthalmopathy are discusse

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1981.tb00610.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYA specific radioimmunoassay for neurotensin has been developed with a sensitivity of 40 pg/ml. Neurotensin‐like immunoreactivity in human plasma shows characteristics similar to synthetic neurotensin on Sephadex G‐25 (f) gel chromatogra

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1981.tb00611.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYTwenty‐one Thai patients with β‐thalassaemia/haemoglobin E and haemoglobin H diseases, 8–20‐years‐old, were studied. These patients had received none or minimal blood transfusions. The important clinical endocrine abnormalities were growth retardation and sexual immaturity. GH secretion was found to be impaired in the majority of patients. Oral GTT showed chemical diabetes in one out of sixteen tested, a much lower incidence than in thalassaemic patients treated by hypertransfusion in the West. The mean insulin levels basally and after glucose loading were lower than those of the normal controls. Thyroid function was normal in all the patients. Serum cortisol and 24‐h urinary oxogenic steroids (17 OGS) levels were normal, as was adrenal cortical reserve in all the patients. The literature on endocrine function in thalassaemia

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1981.tb00612.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYThe effect of insulin on fasting levels of immunoreactive gastric inhibitory polypeptide (IR‐GIP) has been examined in insulin‐dependent, juvenile‐type diabetics who were well‐controlled with two doses of an intermediate insulin. After withdrawal of the evening insulin injection the fasting blood glucose and serum IR‐GIP levels were elevated and decreased significantly following intravenous insulin towards normal values. There was a significant positive correlation between levels of blood glucose and serum IR‐GIP before and during insulin application. It is suggested that fasting serum GIP levels increase in case of insulin deficiency because basal GIP secretion is suppressed by normal ins

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1981.tb00613.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYThe effect of partial thyroidectomy on serum LATS‐P has been investigated in twenty‐one consecutive patients. Before surgery, LATS‐P was detectable in seventeen (81%) but 1 year after operation only five (24%) had activity. The activity did not fall immediately after surgery but declined progressively throughout the year. In no patient was an increase in activity demonstrated; nor did LATS‐P appear in those patients who did not have activity before op

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1981.tb00614.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY