ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1972.tb00402.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

SUMMARYPorcine calcitonin in intravenous doses of 1, 5, 10 and 20 MRC units produced acute increases in urinary volume and sodium, potassium, chloride and bicarbonate excretion in four normal subjects.Infusion of 10 MRC units over a 30 min period in six normal men produced significant increases in urinary volume and sodium, calcium, magnesium, chloride and urea excretion. Urinary potassium, phosphate and bicarbonate were also increased but the increases were not significantly different from control values.These changes in urinary composition accompanied a significant increase in effective renal plasma flow (para‐amino hippurate clearance) and a smaller increase in inulin clearance.It is suggested that porcine calcitonin acts as a renal vasodilator in man and that changes in renal electrolyte excretion occur as a consequence. It is possible that renal vasodilation is effected by an active intermediary released by calcitonin rather than by the hormone itsel

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1972.tb00403.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

SUMMARYSerial measurements of the levels of thyroxine (T4), triiodothyronine (T3) and thyrotrophin (TSH) have been made in sixty‐two patients with thyrotoxicosis during the management of their disease. Thirty‐six patients received131I, twenty antithyroid drugs and six underwent thyroidectomy. All have been followed for 1–2 years. Serum T4concentrations were determined by a modification of the Murphy technique (N: 5–12 μg/100 ml). Serum T3values were assessed by the method of Sterlinget al.(N: 150–270 ng/100 ml). TSH was measured by radioimmunoassay (N: 0–8 μU/ml). The following hormonal and clinical patterns were observed.1 Euthyroidism, with normal T4, T3and TSH in forty‐four patients.2 Persistence of hyperthyroidism with high serum T3(370–676 ng/100 ml), normal T4and undetectable TSH, in four patients treated with131I and in four managed with antithyroid drugs.3 In four out of six patients, clinically euthyroid after131I therapy, serum TSH became elevated (32–93 μU/ml). In this group serum T4was decreased (1.3–3.6 μg/100 ml), but T3was normal or somewhat elevated (170–348 ng/100 ml). Three of these patients eventually developed hypothyroidism and T3levels fell below normal.4 Four patients showed a transient (2–4 months) fall of serum T4below the normal level. Serum T3was normal and they were clinically euthyroid.These results show that during the management of thyrotoxicosis, serum T4may be misleading. The measurement of T3and TSH, in addition to T4, provides a better correlation between clin

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1972.tb00404.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

SUMMARYThe experiment reported in this paper was designed to examine the belief that the mood state (anxiety) associated with thyrotoxicosis was phenomenologically similar to the anxiety occurring in functional (neurotic) states. For this purpose a psychophysiological technique was used which has been shown to be reliable and objective in the differentiation of neurotically anxious patients. It was shown that, unlike the situation in patients with neurotic anxiety states, the psychogalvanic reflex of patients with thyrotoxicosis habituated to a repeated standard stimulus and an initially high rate of spontaneous fluctuations soon settled.The abnormality detected in the thyrotoxic patients consisted of increased reactivity or responsivity and hyperarousal. Although patients with neurotic anxiety states are chronically hyperaroused, the relation of this hyperarousal to the mode of habituation of their psychogalvanic reflex differs from that found for thyrotoxic patients. It seems, therefore, most unlikely that the hyperarousal associated with thyrotoxicosis shares a common origin and mechanism with the hyperarousal occurring in functional (neurotic) anxiety states.

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1972.tb00405.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

SUMMARYThe levels of prostaglandins E, A, and 19 hydroxy A in samples of seminal fluid collected from men attending a fertility clinic have been estimated spectrophotometrically and compared with levels found in samples from fertile men undergoing sterilization by vasectomy. Semen taken from oligo or aspermic men and that from men whose wives proved infertile did not contain significantly different amounts of prostaglandin from samples taken from fertile men. However, a smaller scatter of values for PGE content was found in the group where infertility was unexplained. This was significant (P<0.025). It was also found that considerable deterioration of samples occurred on storage.

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1972.tb00406.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

SUMMARYIn a child with male pseudohermaphroditism (ambiguous external genitalia, XY sex chromosomal constitution and normal adrenocortical function), incubations of testicular tissue with pregnenolone/progesterone, 17α‐hydroxy‐pregnenolone/17α‐hydroxyprogesterone and androstenedione/dehydroepiandrosterone showed that testosterone could be formed from androstenedione and dehydroepiandrosterone only, but not from other substrates. In urine, testosterone did not increase after HCG, but small amounts of pregnanetriolone were found, which increased after HCG and ACTH. There was no DHA increment after ACTH.It is concluded that this patient, as well as a first cousin and a gonadectomized maternal 'aunt' with the same clinical and urinary steroid findings have testicular and adrenal steroid 17,20‐desmolase deficiency, causing a defect of androgen biosynthesis, which has not previously been described. The heredity of this condition seems to be autosomal or X‐

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1972.tb00407.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1972.tb00408.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY