摘要:

SUMMARYThe effect of propranolol on plasma triiodothyronine (T3), thyroxine (T4) and triiodothyronine uptake by Sephadex G‐25 (RT3U%) was studied in fourteen thyrotoxic patients and eight normal volunteers. 40 mg of propranolol as a single oral dose caused significant reduction in total serum T3 which began 60 min after administration. No significant changes were observed in T4 and RT3U% values. Plasma T3 levels remained suppressed during a 5 day course of treatment with propranolol. These results suggest that propranolol has a direct effect on peripheral metabolism of T3 rather than on thyroid hormone secretio

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1977.tb03322.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYImmunoreactive GHRIH is present in normal CSF at a level of 55±28 pg/ml. Immunoreactivity shows mobility identical to synthetic GHRIH standard on sephadex and thin layer chromatography, and can be removed by antibody conjugated to sepharose

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1977.tb03323.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYClinical and biochemical variables were examined during two standardized, low‐dose insulin regimens in seven subjects with diabetic ketoacidosis and one with hyperosmolar coma, in order to determine whether glucagon levels can be suppressed in ketoacidosis and whether hyperglucagonaemia influences the clinical and biochemical responses to treatment. Glucagon concentrations were significantly elevated (36.6‐697.0 pmol/1) at presentation in all subjects. After institution of insulin treatment (4‐8 u/h), glucose and glucagon levels decreased rapidly, and in five of the eight subjects, glucagon levels reached undetectable concentrations (<3.0 pmol/1) during the initial treatment period. Further, neither plasma glucagon concentrations at presentation, nor the rate of glucagon decline during insulin treatment, appeared to influence the rapidity of the glucose decline or the persistence of the ketoacidosis. Thus, low‐dose exogenous insulin suppresses glucagon secretion in diabetic ketoacidosis, and the changes in glucagon concentrations during treatment are unrelated to the clinical r

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1977.tb03324.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARY21 years experience with management of seventeen cases of congenital adrenal hyperplasia due to 21‐hydroxylase deficiency has been analysed with respect to growth, bone maturation and related events at puberty: age at menarche and the occurrence of menstrual irregularities, this study showed that growth retardation is still a problem; that irregular treatment and prolonged exposure to adrenal androgens or oestrogens, may lead to disturbance in hypothalamo‐pituitary‐gonadal function and may be the cause of delayed menarche, or menstrual irregularities in the case of the female. In males the start of puberty and its completion was within the normal

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1977.tb03325.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYWe have previously noted increased platelet aggregation and high von Willebrand factor activity in patients with chemical diabetes. In this paper we have studied platelet aggregation, plasma glucose, insulin, free fatty acids, growth hormone, and von Willebrand factor activity during the glucose tolerance test in six normal and six chemical diabetic subjects. The results suggest that von Willebrand factor activity is suppressed coincident with the rise of glucose and insulin and provide further evidence of hormonal and metabolic control of levels of von Willebrand factor activity.

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1977.tb03326.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYTwo patients are described with elevation of circulating somatomedin A concentration but normal growth hormone levels. One, a young male, appeared clinically acromegalic; the other, a young female, was tall with kyphoscoliosis, and her appearance resembled Marfan's syndrome. In both patients plasma growth hormone concentration was suppressible by hyperglycaemia. It is suggested that their clinical syndromes resulted from excessive somatomedin activity.

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1977.tb03327.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYTo examine the effects of age and use of oestrogen‐progestogen oral contraceptive agents (OCA) on urinary calcium excretion, 24 h urine collections were obtained from 525 women aged 16‐69 years during a health survey, and measurements made of the amounts of calcium, creatinine, sodium, potassium and magnesium excreted. Younger women using OCA excreted more potassium and creatinine but less calcium, and less calcium and magnesium relative to creatinine, than corresponding controls using no OCA. Older women excreted less creatinine, but significantly greater amounts of calcium, sodium, potassium and magnesium relative to creatinine than younger women.It is postulated that the diminished urinary calcium excretion observed in women using OCA resulted from suppression of bone resorption by oestrogens in

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1977.tb03328.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYThe interrelationships of increased plasma renin and elevated blood pressure following acute β‐stimulation by orciprenaline and its prevention by somatostatin was studied in normal man. During somatostatin infusion basal values of renin and blood pressure were unchanged. Following orciprenaline both variables increased significantly. Combination of somatostatin and orciprenaline reduced the rise in plasma renin activity by 49%, mean arterial blood pressure by 21% and heart rate by 19%, compared with β‐stimulation alone.The results indicate that the inhibitory action of somatostatin on plasma renin activity may be mediated via β‐receptors. The lesser increase of blood pressure under somatostatin plus orciprenaline also indicates a possible inhibitory effect of somatostatin on β‐adrenergi

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1977.tb03329.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Book review in this ArticlesOutline of Endocrine Gland Syndromes. 3rd Ed. by T. S. DANOWSKI. The Williams and Wilkins Company, BaltimoreUltrasonography of the Abdomen. By NASSER HASSAIAN, Springer‐Verlag, 1976. Pp. 127. Go

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1977.tb03330.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1977.tb03332.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY