摘要:

SUMMARYThe growth hormone response to the administration of the currently available synthetic hypothalamic hormones was assessed in eleven patients with acromegaly. Eight of them showed a positive GH response to thyrotrophin releasing hormone and three showed no response. The GH response to TRH was shown to be unrelated to the thyrotrophin response to TRH. The GH response to TRH was inhibited by the administration of growth hormone release inhibiting hormone. Luteinizing hormone/follicle stimulating hormone releasing hormone (LHRH) caused a positive GH response in four patients, but this was trivial in three.The TRH mediated GH release in acromegaly is not mediated via TSH and appears to be attributable to loss of specificity of the receptor sites on the somatotroph to the hypothalamic hormones.

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1975.tb01554.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYA patient with metastatic insulinoma who suffered from severe hypoglycaemic attacks was treated with 7.5 of streptozotocin (Upjohn). Shortly after the start of treatment, the hypoglycaemic attacks ceased; fasting blood glucose levels and serum immunoreactive insulin values returned to normal upon completion of the treatment. Two years after treatment, the patient is well and active and has not had any attacks. The oral glucose tolerance test and tolbutamide stimulation test now show serum immunoreactive insulin excertion patterns similar to those seen in diabetics.

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1975.tb01555.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYThe specimen of thyroid resected at partial thyroidectomy from 103 patients with primary thyrotoxicosis was studied with histometric and organ culture techniques. Twenty‐seven patients had been prepared for operation with propranolol and seventy‐six with carbimazole: all received Lugol's iodine for 10 days before operation.The resected specimen and deduced total thyroid weight was greater in the patients prepared with carbimazole. There was no absolute qualitative histopathological difference in the appearance of the glands of the two groups of patients, but histometry showed that the volume percentage of colloid and total gland colloid weight was significantly greater in the patients prepared with carbimazole: the volume percentage of epithelial cells and the total gland epithelial cell weight was similar in the two groups.The iodide concentrating capacity per g wet weight thyroid tissue or per unit volume of colloid did not differ significantly between the two groups. However, the iodide concentration capacity per unit volume of epithelial cells was significantly higher in the carbimazole prepared patients than in those prepared with proprano

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1975.tb01556.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYGonadotrophin secretion by the pituitary was tested by i.v. injections of synthetic LH and FSH releasing hormone (LHRH) in five normal women between day 21 and day 25 of the luteal phase of the cycle, in twelve women receiving contraception with i.m. injection of medroxyprogesterone acetate and in eight women taking combined oral contraceptives of different varieties. Treatment with oral contraceptives led to a decrease or even to complete suppression of the response and possibly the reserve capacity of both LH and FSH secretions.Treatment with medroxyprogesterone acetate for several years lowered basal serum LH and FSH as did oral contraceptives but had much less effect on the responses to LRH.In long‐term steroid contraception, progestogens alone seem to exert much less deleterious effect on gonadotrophin function than when used in combination with an oestroge

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1975.tb01557.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYPlasma glucagon response to an arginine infusion was studied in children and adolescents belonging to the following groups: (I) twenty‐two controls; (II) six subjects with delayed insulin peak during oral GTT; (III) ten diabetics on diet and/or oral therapy; (IV) six newly diagnosed uncompensated diabetics; and (V) eight diabetics on insulin therapy. The fasting glucagon concentrations and rise of glucagon in response to arginine in the patients of Groups II, III and V were similar to those of the controls (Group I).The basal levels and rise of glucagon in the newly diagnosed, uncompensated diabetic children (Group IV) was elevated compared to the other groups but the difference was statistically not significant.The results of this investigation favour the hypothesis that the hyperglucagonaemia in diabetes is a secondary effect to the metabolic derangement, bearing a direct relationship to the degree of homeostastic decompensatio

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1975.tb01558.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYThe response of plasma aldosterone to fludrocortisone administration (400 μg 12‐hourly for 3 days) was studied in twenty‐two patients with primary hyperaldosteronism. No difference was observed in the response between those patients with an adrenal adenoma and those with bilateral adrenocortical hyperplasia, there being no significant change in plasma aldosterone levels across the test period. No separation between the groups was seen when basal plasma renin concentration was related to the aldosterone level following fludrocortisone. It is concluded that the test is of little value in the pre‐operative differentiation of these conditions.Twenty‐three patients with no demonstrable cause for their hypertension and four with elevated levels of plasma deoxycorticosterone were similarly studied for comparison. These groups demonstrated a normal fall in plasma aldosterone levels following fludroc

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1975.tb01559.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYThe effects of adrenergic α and β receptor blockade on the thyrotrophin and prolactin responses to TRH were studied in groups of hyperthyroid patients who received either oral propranolol and phenoxybenzamine or intravenous propranolol and rogitine. The flat TSH and prolactin responses to TRH in the untreated hyperthyroid patients were not altered by oral or intravenous adrenergic α and β receptor blockade suggesting that catecholamines do not play a major role in the feedback suppression of TSH and prolactin in hyperthyroid

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1975.tb01560.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYA rapid radioimmunoassay for the determination of dehydroepiandrosterone sulphate (DHEA‐S) in diluted human plasma is described. The radioimmunoassay is performed using an antiserum to DHEA‐3‐hemisuccinate‐BSA. A charcoaldextran mixture is used for separation of the bound from the free fraction. The reliability criteria of the method in terms of precision, accuracy, sensitivity and specificity have been evaluated.The mean level of DHEA‐S in plasma samples from normal men (age range 24‐37) is 241.5±72.5 μg/dl. In normal premenopausal women the highest values are in the second third of the menstrual cycle (corresponding to the ovulatory phase). In normal old men (age range 64‐86) and in post‐menopausal women (age range 55‐88) the mean values are, respectively, 51.9±33.8 and 53.8±34.0.The DHEA‐S levels found in several cases of adreno‐cortical disorders are reported. In primary adrenal insufficiency and in Cushing's syndrome due to adrenal adenoma or bilateral multinodular hyperplasia low values are found; in Cushing's syndrome due to bilateral adrenal hyperplasia normal

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1975.tb01561.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYA radioimmunoassay for determination of dihydrotestosterone (DHT) in man is described. After extraction from plasma, DHT is separated by paper chromatography.The radioimmunoassay is performed using an antiserum to dihydrotestosterone‐3‐oxime‐BSA and a charcoal‐dextran mixture is used to separate the free from the bound fraction. The reliability criteria of the method in terms of precision, accuracy, sensitivity and specificity have been evaluated.The mean level of DHT in plasma samples from young (age 21‐37) and old (age 65‐90) normal men is respectively (mean ± SD) 54.7 ± 19 ng/dl (n= 17) and 39.1 ± 19 ng/dl (n= 14). The difference is statistically significant (P<0.01). The values found in seven patients with Klinefelter's syndrome (21.0 ± 6 ng/dl) are significantly lower than normal young subjects (P<0.01).Lastly, the DHT levels found in a mixed group of male hypogonadism (azoospermia, due to tubular failure, germinal cell aplasia and anorchi

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1975.tb01562.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYTwo women with thyrotoxicosis were treated with antithyroid drugs during pregnancy. One women had inadvertently received a therapeutic dose of radioiodine at 21 weeks gestation and the other suffered from severe thyrotoxicosis with a serum LATS level of 1850%. In both patients, the serum triiodothyronine was maintained above 500 ng/dl by the concurrent oral administration of this hormone. Despite this precaution, cord serum thyrotrophin levels were markedly elevated and both infants showed clinical signs of hypothyroidism at birth. This experience indicates that triiodothyronine does not prevent fetal hypothyroidism when given to the mother in pharmacological amounts.

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1975.tb01563.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY