摘要:

SUMMARYThe effects of endogenous and exogenous oestrogen on serum concentrations of oestrogen stimulated neurophysin (ESN) were studied in women with regular menstrual cycles and patients with anovulation. In ten menstrual cycles serum ESN concentrations rose steadily from 305 ± 16 ng/l (mean ± SEM) in the early follicular phase to reach maximum concentrations at about the time of ovulation (601 ± 106 ng/l). There were significant correlations between ESN and oestradiol concentrations in nine of the ten cycles (P<0·05). The concentration in the mid luteal phase (386 ± 43 ng/l) was also significantly greater than at the beginning of the cycle (P<0·05).Stimulation of endogenous oestrogens by treatment with clomiphene was accompanied by a release of ESN. Oestrogen concentrations were significantly lower in 5 months in which ovulation did not occur than in ten treatments in which ovulation did occur (P<0·05). The amount of ESN produced however, was similar in the two groups.The basal concentration of ESN was within the range found in the early follicular phase of the cycle in twenty of the thirty‐seven patients with anovulation in whom it was measured. Concentrations tended to be low in patients with anorexia nervosa or hyperprolactinaemia and oestrogen concentrations were also low. Levels were high in oligomenorrhoea but oestradiol concentrations were normal.Serum ESN concentrations in oestrogen provocation and amplification tests reached maximum values in normal subjects 48 h after the administration of oestradiol benzoate: LH concentrations continued to rise until 72 h. In twenty‐one of forty‐one provocation tests on anovular patients the amount of ESN released was within the range for normal controls: twelve released less and eight released more. There was no correlation between the basal ESN values and the ESN released.There was intact positive LH feedback in sixteen of the forty‐one tests performed. In all except two tests with positive LH feedback, ESN was also released, but in the twenty‐five tests with no evidence of LH positive feedback there was normal release of ESN in twelve, reduced release in ten and excessive release in three. In the amplification tests LHRH was without effect on the ESN concentrations before or after oestrogen administration.It is concluded that either the release of LH stimulated by oestrogen is independent of the release of ESN, or it is stimulated at different threshold levels of oestrogen. ESN is more readily released than LH and the mechanism is probab

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1981.tb00657.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYA radioimmunoassay has been developed for the N‐terminal region of human pituitary pro‐opiocortin (N‐POC), the common precursor protein of ACTH and β‐LPH, using an antiserum which recognizes residues near the γ‐MSH region. The concentrations of greater than 300 ng/l of immunoreactive peptide were determined in unextracted human plasma, the relative molecular mass of the reacting fragments corresponding to a seventy‐seven amino acid glycoprotein. The concentrations of immunoreactive N‐POC peptides were correlated with those of ACTH in plasma obtained from patients with various disorders of the hypothalamic‐pitui

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1981.tb00658.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYSeventeen undialysed adult patients with chronic renal failure took part in a controlled study of the effects of 1,25(OH)2D3and D3. After a 6‐month observation period the patients were allocated at random to two groups for 6 months of treatment with either 1,25(OH)2D3(mean dose 0·5 μg daily) or D3(dose 100 μg daily). Treatment was then discontinued and the patients were studied for a further 6 months.Serum iPTH was decreased in both groups but most markedly in the 1,25(OH)2D3group in which the iPTH values became normal. Serum creatinine increased during treatment in both groups. In the group receiving 1,25(OH)2D3this was coupled to an increase in serum calcium within the normal range.Our data demonstrate that 1,25(OH)2D3treatment in patients with chronic renal failure leads to a further reduction in renal function, which may be partially reversible. Physicians should therefore be reluctant to give vitamin D analogues to patients with chronic renal failure unless they have severe symptomatic renal osteodystr

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1981.tb00659.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYSeventeen undialysed adult patients with chronic renal failure took part in a controlled study of the effects of 1,25(OH)2D3and D3. After a 6‐month observation period the patients were allocated at random to two groups for 6 months of treatment with either 1,25(OH)2D3(mean dose 0·5 μg daily) or D3(dose 100 μg daily). The treatment was then discontinued and the patients were studied for a further 3 months.In the 1,25(OH)2D3group the mean serum concentration of 1,25(OH)2D rose significantly during treatment, whereas serum concentrations of 25OHD and 24,25(OH)2D remained unchanged. In the D3group there was a highly significant increase in serum concentrations of 25OHD and 24,25(OH)2D, whereas serum 1,25(OH)2D remained unchanged.There was a significant fall in serum iPTH in both treatment groups. This fall was unrelated to serum calcium in the D3group unlike the findings in the 1,25(OH)2D3group. The data support previous experimental evidence that serum iPTH can be suppressed by 24,25(OH)2D3and suggest that this analogue may be of clinical importance in the treatment of chronic renal failure without inducing hypercalca

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1981.tb00660.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYLHRH tests were performed in two children with Bartter's syndrome before and during treatment with prostaglandin synthesis inhibitors. Before treatment, in patient 1 both basal and peak FSH and LH levels were elevated; in patient 2 basal and peak FSH levels were above the normal range, while basal and peak LH levels were normal. During treatment with an inhibitor of prostaglandin synthesis, abnormal values decreased into the normal range. These results support a possible role of endogenous prostaglandins in regulating gonadotrophin secretion in humans.

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1981.tb00661.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYCarbamazepine (CBZ) decreases the serum concentration of thyroid hormones. It is proposed that CBZ increases the extra‐thyroidal metabolism of thyroid hormones. In order to test this hypothesis CBZ was given to nine hypothyroid patients substituted with thyroxine (T4). A significant decrease in serum concentrations of T4, calculated free T4 (FT4), triiodothyronine (T3), and calculated free T3 (FT3) was found after 3 weeks of CBZ medication. The serum concentrations of TSH and the T4:T3 ratios were unaltered, while the serum concentrations of T4‐binding globulin (TBG) increased markedly in eight of the nine patients. These findings support the hypothesis of a CBZ induced increase in the extra‐thyroidal metabolism of thyroid hor

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1981.tb00662.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYWe were able to observe the effect of withdrawal of endogenous sympathetic drive in a hypertensive patient with an aldosterone‐secreting adrenal adenoma. Acute stimulation of both carotid sinus nerves lowered blood pressure to normotensive or hypotensive levels by reducing peripheral resistance. When chronic carotid sinus nerve stimulation was discontinued, peripheral resistance and blood pressure increased. These data suggest that the sympathetic nervous system is important in the maintenance of hypertension in established primary aldosteronis

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1981.tb00663.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYMonoclonal antibodies recognizing specific antigenic determinants of peripheral T‐lymphocytes (OKT3PAN), helper T‐cells (OKT4IND) and suppressor T‐cells (OKT8SUP) were used to study the immune regulation in autoimmune thyroiditis. An indirect immunofluorescence microscopy method was employed to quantify the number of different subtypes. In addition, B‐lymphocytes were also studied using a fluorescent surface Ig detection technique. Patients with autoimmune thyroiditis—independent of their clinical status—show a decrease in the number of suppressor T‐lymphocytes. This finding, in agreement with other functional tests, indicates that the autoimmune phenomenon is linked to a decreased T‐supp

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1981.tb00664.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYOptimum conditions for a sensitive and highly precise radioimmunoassay of LHRH were established. Precipitation and removal of interfering substances and concentration of the resultant LHRH extracts from peripheral plasma were also achieved. Using these methods, daily plasma LHRH levels in females with normal menstrual cycles were measured and correlated with the corresponding LH and FSH levels. The levels of LHRH in the peripheral plasma of postmenopausal females, as well as eugonadal males, were also determined.The LHRH profile in normal cycling women was found to be cyclic but the peak LHRH levels were observed at the beginning of the rise in LH and FSH levels and preceded the midcycle surge of gonadotrophins. The LHRH levels in the luteal phase (19·8 ± 1·1 pg/ml, mean ± SEM) were significantly (P<0·01) higher than those in the follicular phase (16·5 ± 0·5 pg/ml) of the menstrual cycle. A high degree of correlation (r = 0·91) was seen between the immunoreactivity and biological activity of the extrac

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1981.tb00665.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARYIn the present study, effects of domperidone, a peripheral dopamine blocking agent, on prolactin and growth hormone were examined to determine whether dopamine regulation of these hormones involved structures external to the blood‐brain barrier. A clearcut elevation in prolactin was produced by domperidone. GH response to apomorphine was partially blocked by domperidon

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1981.tb00666.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY