摘要:

The frequencies of pathological results in 143 CSF samples of MS patients from the years 1964–1967, and 206 samples from 1968–1973 were compared after agar electrophoresis and cytological differentiation. As they were in good agreement, the two series were combined into one group of 349 MS patients for further comparison with three groups with other neurological diseases (inflammatory, neoplastic and vascular brain affections). Although the absolute γ-globulin values (mg/l) are somewhat more frequently pathological than the relative values (rel%), they also correlate significantly with total protein and, therefore, do not offer a criterion with a diagnostic value of its own. From them - as from the total protein – a pathological CSF state can be concluded, but no discrimination between MS and other diseases of the central nervous system is possible. The relative percent values for the γ-globulins are much less correlated with total protein in all the 4 groups compared; consequently, they represent a more specific criterion for differential diagnosis. Compared with MS the frequency of an increased relative GG content is about the same in other inflammatory diseases of the CNS, but decreases by a factor of 3 in brain tumors and by a factor of 6 in vascular affections of the CNS. In order to distinguish between MS and other brain diseases the relative GG values together with the total protein and the observation of oligoclonal zonation of the γ-globulin region are therefore most valuable diagno

ISSN:0014-3022    

DOI:10.1159/000114669

出版商:S. Karger AG    

年代:1975

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000219447

出版商:S. Karger AG    

年代:1903

数据来源: Karger

摘要:

Systemic blood cyclic AMP levels were elevated but urinary excretion was unaltered in patients with recent cerebral infarction. Cerebral venous levels for cyclic AMP were significantly higher than arterial levels. CSF cyclic AMP levels were also elevated. After intravenous 10% glycerol, CSF cyclic AMP levels decreased and cerebral A-V differences were reduced. Elevation of cyclic AMP levels in plasma may be due to alteration of neuroendocrinal function after cerebral infarction and contributed to in part by release from infarcted brain. Cyclic AMP release into cerebral venous blood and CSF suggests (1) blood brain barrier damage and (2) extracellular cyclic AMP accumulation in infarcted brain secondary to abnormal neurotransmitter release and/or impaired cellular function which appears to be partially reversed by glycerol.

ISSN:0014-3022    

DOI:10.1159/000114670

出版商:S. Karger AG    

年代:1975

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000219448

出版商:S. Karger AG    

年代:1903

数据来源: Karger

摘要:

The morphological and histochemical findings in a brain biopsy of a case of Creutzfeldt-Jacob disease are compared. The histochemical changes in the cytoplasm of the neurons precede the morphological alterations found with the electron microscope. In this way the neuronal enzymatic failure can explain the clinical picture of this disease.

ISSN:0014-3022    

DOI:10.1159/000114671

出版商:S. Karger AG    

年代:1975

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000219449

出版商:S. Karger AG    

年代:1903

数据来源: Karger

摘要:

Central nervous system manifestations developed in a patient suffering from the chronic, adult form of Gaucher’s disease. At autopsy, massive systemic fat embolism was found, involving mainly the brain and the lungs. As there was no evidence of bone fracture, or trauma to the adipose tissues, it is presumed that the severe skeletal involvement by the Gaucher’s disease led to the development of the fat embolizat

ISSN:0014-3022    

DOI:10.1159/000114672

出版商:S. Karger AG    

年代:1975

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000114673

出版商:S. Karger AG    

年代:1975

数据来源: Karger