摘要:

Two patients with signs of carbamazepine neurotoxicity after combined treatment with verapamil showed complete recovery after discontinuation of the calcium entry blocker. Use of verapamil in combination with carbamazepine should either be avoided or prescribed only with appropriate adjustment of the carbamazepine dose (usually reduction of the carbamazepine dose by one half).

ISSN:0014-3022    

DOI:10.1159/000116239

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

Four patients who experienced isolated transient global amnesia had computed tomographic evidence for a cerebral infarct (3 cases) or hemorrhage (1 case). The medial part of the temporal lobe was involved in 2 patients (left in 1, right in 1), the left lentiform nucleus in 1 patient, and the left thalamus in 1 left-handed patient. These findings suggest that transient global amnesia may be associated with stroke in some cases, but it has no localizing value within the temporodiencephalic structures. No cerebrovascular events occurred over a 1-to 5-year follow-up, suggesting that transient global amnesia with infarction or hemorrhage is not a strong predictor of further stroke.

ISSN:0014-3022    

DOI:10.1159/000116240

出版商:S. Karger AG    

年代:1988

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000209688

出版商:S. Karger AG    

年代:1910

数据来源: Karger

摘要:

Fifty-five patients admitted to hospital for ‘pure’ transient global amnesia (TGA) were studied and followed up for a period ranging from 12 to 67 months. The major pathogenetic theories of TGA (epileptic, thrombotic and migrainous) were investigated through the study of clinical histories and risk factors and the recurrences of neurological disturbances during follow-up. Seventy-one percent of the sample had one or more thrombotic risk factors (TRF), 2 patients had both TRF and a history of migraine, and none ever experienced a seizure. A computerized tomography (CT) scan was performed in 40 out of 55 patients to detect focal lesions: 3 patients (7.5%) had a lacuna in the deep structures of the brain. Over the follow-up period, 1 patient died from hepatic cirrhosis, 1 patient died from cerebral haemorrhage, 2 patients experienced transient ischaemic attacks and 3 patients had a total of 4 TGA recurrences. Our conclusion is that TGA represents a benign form of transient ischaemic cerebral dise

ISSN:0014-3022    

DOI:10.1159/000116241

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

Focal or generalized hemorrhage is a commonly encountered complication in patients with many kinds of amyloidosis. We studied 24 patients (18 males, 6 females) with familial amyloidotic polyneuropathy and found that five had experienced one or more bleeding episodes. In four of these five patients, bleeding occurred in the terminal stage. The incidence of hemorrhage in familial amyloidotic polyneuropathy is lower than that of other types of amyloidosis or that which has been reported in this disease. In our experience clotting abnormalities were rare; clotting factor deficiency appeared not to exist in familial amyloidotic polyneuropathy.

ISSN:0014-3022    

DOI:10.1159/000116242

出版商:S. Karger AG    

年代:1988

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000209689

出版商:S. Karger AG    

年代:1910

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000209690

出版商:S. Karger AG    

年代:1910

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000209691

出版商:S. Karger AG    

年代:1910

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000209692

出版商:S. Karger AG    

年代:1910

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000209693

出版商:S. Karger AG    

年代:1910

数据来源: Karger