摘要:

Transient hyperkinesia was observed in a 16-year-old epileptic and mentally retarded patient after a single intravenous perfusion of diphenylhydantoin (DPH). No clinical signs of DPH intoxication were associated with the movement disorder. Repeated plasma anticonvulsant level determinations never showed toxic concentrations of DPH. Since a few spontaneous episodes of hyperkinesia had been observed before, the DPH intravenous perfusion could have unmasked a preexisting latent movement disorder in our patient. However, neuroradiological investigations failed to demonstrate the existence of any anatomical damage of the basal ganglia, and HVA as well as 5-HIAA levels measured in the CSF with the probenecid technique were within the normal range 2 months after cessation of hyperkinesia. HVA and 5-HIAA levels have also been measured in the CSF during the period with hyperkinesia; the results are discussed with reference to previously published data concerning cerebral monoamine metabolism in drug-treated epileptic patients.

ISSN:0014-3022    

DOI:10.1159/000115065

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The possibility that epileptic seizures and classic migraine episodes may occur in the same patient is discussed. The probable relationship between the neurophysiological mechanisms which underlie both types of attacks has not yet been agreed upon. The case of a young man who suffered from classic migraine and who presented two convulsive epileptic attacks, preceded by visual aura is described. The EEG showed an epileptogenic occipito-temporal focus which corresponded to the region of the scotoma origin. A possible connection between scotoma in migraine and epileptic discharge is discussed. It is proposed that spreading depression, as the basis of the migraine prodomata, was preceded by a moment of intense neuronal excitation which changed the epileptic intercritical activity into a critical one.

ISSN:0014-3022    

DOI:10.1159/000115066

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

A young male patient affected with Lafora’s disease and concomitant mental deterioration, myoclonic jerks and epileptic seizures is reported. A cerebral biopsy showed round PAS-positive myoclonus bodies in nerve cells and neuropile. A tendency to periodic recurrence of paroxysmal activity in the EEG tracings, an unusual finding in Lafora’s disease, is briefly discus

ISSN:0014-3022    

DOI:10.1159/000115067

出版商:S. Karger AG    

年代:1979

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000213426

出版商:S. Karger AG    

年代:1906

数据来源: Karger

摘要:

Isolated myelin basic protein (MBP) was less effective than an equivalent amount of spinal cord in inducing protection against experimental allergic encephalomyelitis produced by a challenge of either cord, purified myelin or MBP. Complete protection was only obtained when an MBP challenge was preceded by spinal cord treatment. There was a 100% incidence of disease in the guinea pigs pretreated with MBP before challenge with spinal cord or myelin, but the onset was delayed by 3–4 weeks and the disease was less severe than in the controls. Recurrent disease was seen in some control and pretreated animals challenged with spinal cord but not in animals challenged with MB

ISSN:0014-3022    

DOI:10.1159/000115068

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

In successive lumbar samples of cerebrospinal fluid (CSF), each consisting of 5 ml, immunoglobulin G (IgG) and total protein were determined. Variation was studied by comparing the values in the initial sample with values in succeeding samples. In 13 out of 17 patients, IgG was reduced in sample 2. There was no reduction in the following samples. The concentration of IgG in sample 2 was below 50% of the concentration in sample 1 in 2 patients and below 70% in 9 patients. IgG was also reduced if the concentration in each sample was given as percent of the total protein concentration. The total protein concentration was not significantly reduced during collection of 25 ml of CSF. IgG was increased in sample 2 in 3 out of the 4 patients with neurological diseases since childhood. In 1 patient there was a considerable rise in the total protein concentration after collection of the first 5 ml, without a corresponding rise of IgG concentration. In clinical practice, the portion to which the CSF sample belongs should be noted, and comparison of values from various patients should be made between equivalent samples.

ISSN:0014-3022    

DOI:10.1159/000115069

出版商:S. Karger AG    

年代:1979

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000316431

出版商:S. Karger AG    

年代:1906

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000213427

出版商:S. Karger AG    

年代:1906

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000213428

出版商:S. Karger AG    

年代:1906

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000213429

出版商:S. Karger AG    

年代:1906

数据来源: Karger