摘要:

Auditory brainstem responses (ABR) have been obtained in 22 patients, 15 with familial and 7 with sporadic olivopontocerebellar atrophy; 8 of them were pairs of siblings. ABR abnormalities have been found in 72.7%, with a significant higher percentage in familial versus sporadic patients. Similar ABR patterns have been obtained in affected members of the same family. No correlations have been found between ABR results and the following parameters: age, gender, disease duration, degree of clinical involvement and fashion of inheritance. ABR pattern did not show any modification over a follow-up period of 15–24 months. Our findings suggest that the involvement of the auditory pathways may be under genetic contro

ISSN:0014-3022    

DOI:10.1159/000116286

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

In 21 parkinsonian patients, we investigated the contents of blood serotonin (5HT) and benzylamine oxidase (BzAO) before and during L-dopa therapy. Then, we studied the patients prospectively, and evaluated the relationship between 5HT and BzAO and the clinical characteristics. The levels of blood 5HT and BzAO varied not only with the treatment, but also with the duration and clinical type of the disease. We postulated that in certain types of Parkinson’s disease, the generalized defect of 5HT and enzyme metabolism might primarily exist, and might influence the efficacy of L-dopa therapy and the prognosis of the diseas

ISSN:0014-3022    

DOI:10.1159/000116287

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

REM sleep behaviors were recently described as wild, dream-enacting behaviors during REM sleep with loss of usual atonia on submental muscles. We examined 6 patients (5 M, IF) with characteristic episodes of behavioral manifestations during REM sleep. Polysomnographic data indicate a decrease in first REM latency, an absence of stage 4 NREM, altered phasic motor activity and behavioral episodes during REM sleep even with normal chin muscle atonia. Three patients had Shy-Drager syndrome, 1 olivopontocerebellar atrophy and 2 patients had no neurological disease. The crucial importance of a disinhibited locomotor system during sleep appears to be responsible for this REM parasomnia.

ISSN:0014-3022    

DOI:10.1159/000116288

出版商:S. Karger AG    

年代:1988

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000209714

出版商:S. Karger AG    

年代:1910

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000209715

出版商:S. Karger AG    

年代:1910

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000209716

出版商:S. Karger AG    

年代:1910

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000209717

出版商:S. Karger AG    

年代:1910

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000209718

出版商:S. Karger AG    

年代:1910

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000209719

出版商:S. Karger AG    

年代:1910

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000209720

出版商:S. Karger AG    

年代:1910

数据来源: Karger