摘要:

The results from systematic determinations of the serum level of phenytoin in 121 epileptic children are reported. The range 12–25 mg/1 is effective in most of the children, responding at all to phenytoin, and causes few and minimal side effects. Practically all children with pure grand mal epilepsy could be kept seizure-free on an optimal dose of phenytoin alone. Possibly the level aimed at should be higher in severe cases than in mild ones. Our initial dose was 10 mg/kg daily; this dose was adjusted according to the serum level until the desired range was reached. Phenytoin produced a lower serum level than the same dose of its sodium salt. Interaction possibly occurs with carbamazepine, which tended to decrease the level, and with acetazolamide, which tended to increase the level. With the help of serum phenytoin determinations an individual dose can be chosen for each patient and phenytoin therapy be rendered safer and more effectiv

ISSN:0014-3022    

DOI:10.1159/000114679

出版商:S. Karger AG    

年代:1975

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000219455

出版商:S. Karger AG    

年代:1903

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000219456

出版商:S. Karger AG    

年代:1903

数据来源: Karger

摘要:

A reticulum cell sarcoma was diagnosed in a myasthenic patient 14 years after the first manifestations of myasthenia gravis. The association of myasthenia and malignancy, especially lymphoreticular, is discussed in view of an increasing number of similar reports in the literature. It is suggested that autoimmune diseases, myasthenia gravis and malignant processes might have a common underlying abnormal immune state related to thymic pathology.

ISSN:0014-3022    

DOI:10.1159/000114680

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

A case of Creutzfeldt-Jakob disease of cerebellar type is reported. In this case the cerebellar cortex exhibited classical Kuru-plaques. From a comparison of this finding with 50 cerebella from senile patients and patients with cerebellar atrophies it is concluded that the Kuru-plaque is specific for Creutzfeldt-Jakob disease, possibly even for its cerebellar variant.

ISSN:0014-3022    

DOI:10.1159/000114681

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

The present paper is a study of a microcystic intraspinal tumour that developed in a 4-year-old child. The histologic examination showed the presence of neuroblastic elements developing next to smooth muscle fibers. The tumour had diffusely invaded the meninges, presenting a marked collagen reaction. Ultrastructurally, the neuroblastic elements exhibited an arrangement proper to the neural tube and the presence of a series of osmiophil neurosecretory dense-core vesicles. The fine structural morphology of the smooth muscle fibers was clearly revealed, the cells containing microfibrils and being delimited by a basement membrane. The muscular fibers were visibly in contact with the blood vessels. These aspects demonstrate that the medullomyoblastoma is a malignant bidermal teratoid tumour of the central nervous system. Dysgenesis of the ectomesenchyma may be considered to stand at the basis of the development of this type of tumour.

ISSN:0014-3022    

DOI:10.1159/000114682

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

A 65-year-old woman showed the clinical picture of a myogenic myopathy, confirmed electromyographically. Detailed histopathological, histochemical and ultrastructural studies were performed on deltoid and quadriceps femoris biopsy specimens. Many muscle fibres were found to contain vacuolar spaces with lipid droplets: perivascular inflammatory changes were also observed. The affected fibres were consistently type I. Under the electron microscope the fibres contained large numbers of lipid droplets, usually next to normal mitochondria. A slight improvement occurred after prednisone therapy.

ISSN:0014-3022    

DOI:10.1159/000114683

出版商:S. Karger AG    

年代:1975

数据来源: Karger