摘要:

Three patients with midbrain lesion are described who showed trigeminal sensory symptoms in the contralateral side. Two with ischemic stroke showed partial oculomotor paresis while the third with probable vascular malformation had trochlear palsy. Considering their clinical manifestations and magnetic resonance findings, their sensory changes are believed to be caused by the involvement of the crossed trigeminothalamic fibers near the ocular motor nuclei.

ISSN:0014-3022    

DOI:10.1159/000116940

出版商:S. Karger AG    

年代:1993

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000203093

出版商:S. Karger AG    

年代:1913

数据来源: Karger

摘要:

Arm tremor in Parkinson’s disease occurs during rest which has been explained by a specific tremulous mechanism activated during rest. During action or posture maintenance, the tremor may persist or recur, but with reduced amplitude. We present 2 patients with idiopathic Parkinson’s disease who showed persisting arm tremor which was most marked during action rather than during rest. The patterns of upper limb tremor were investigated during rest, maintenance of fixed posture, and slow movement, using an advanced computerized movement-monitoring system (Coda 3). Four parkinsonian patients showing tremor under all conditions were studied, comparing 2 patients whose tremor was most marked during rest with 2 whose tremor was most marked during action. All showed intermediate amplitudes during posture maintenance. Patterns of tremor frequency were very similar between patients, irrespective of amplitude characteristics. These features suggest that tremors in all patients originate in a single, complex mechanism which may involve both central and peripheral mechani

ISSN:0014-3022    

DOI:10.1159/000116941

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

We have quantified the soluble class I antigen (sHLA) secretion by peripheral blood lymphocytes of 26 multiple sclerosis (MS) patients. Thirteen of them were in a stable phase of the disease, 6 on relapse and 7 suffered from a progressive MS. sHLA secretion was reduced in the presence or absence of phytohemagglutinin in patients with either active or stable MS, being normal after stimulation with a monoclonal antibody anti-CD3. In MS patients, lymphocyte proliferation and immunoglobulin secretion were found to be similar to those of 29 healthy blood donors who comprised the group of controls. These results reflect systemic anomalies in the cell activation process in MS, which seem to be independent of the disease activity. Whether these alterations are specific to MS or are common to other inflammatory CNS diseases remains to be elucidated.

ISSN:0014-3022    

DOI:10.1159/000116942

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

In this study we evaluated the sensitivity of neuroradiological and neurophysi-ological tests for detecting brain stem (BS) lesions in multiple sclerosis patients, since the recent introduction of the gradient motion rephasing technique has markedly increased the image quality of magnetic resonance imaging (MRI). From 50 MS patients (33 women and 17 men; mean age 35.9 ± 8.3 years; mean duration of the disease 7.2 ± 4.1 years) with clinical signs of BS involvement, brain MRI, BS auditory evoked potentials (BAEPs), and left and right median somatosensory evoked potentials (mSEPs) were obtained. BS MRI lesions were detected in 41 patients (82%); in 14 cases they were located in the medulla oblongata, in 55 in the pons, and in 24 in the midbrain. Single lesions were present in 20 patients, while two or more BS lesions were demonstrated in 21 patients; 30 patients had at least one lesion located close to the inner or the outer cerebrospinal fluid border. BAEPs were abnormal in 19 of the 50 patients (38%), and BS components of mSEPs were abnormal in 15 of 46 (33%). With combined use of these neurophysiological techniques, BS abnormalities were revealed in 24 patients (48 %). Only 1 patient had neurophysiological BS abnormalities and normal MRI. Moreover, there was a good correlation (74%) between the clinical and MRI BS findings in the 23 patients with signs referable to focal neurological BS lesions. The concordances considering clinical and evoked potential reports were positive, but less marked. Our data demonstrate that a thin-slice MRI examination using the gradient motion rephasing technique is far more sensitive than BAEPs or mSEPs for detecting BS-demyelinating lesion

ISSN:0014-3022    

DOI:10.1159/000116943

出版商:S. Karger AG    

年代:1993

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000203094

出版商:S. Karger AG    

年代:1913

数据来源: Karger

摘要:

A 30-year-old woman, who had had two episodes of distal dominant sensorimotor disorders in the extremities, developed again sensorimotor involvement in the distal portion of all limbs. She was also found to have hyperhidro-sis, tachycardia and goiter. Neurological and endocrinological examinations led to a diagnosis of coexistence of recurrent polyradiculoneuropathy and hyperthyroidism. Treatment with thiamazole resulted in improvement of the neurological features as well as of hyperthyroidism. The relationship between polyradiculoneuropathy and hyperthyroidism is discussed.

ISSN:0014-3022    

DOI:10.1159/000116944

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

We report a case of the unusual panencephalopathic type of Creutzfeldt-Jakob disease (CJD) in Taiwan. This 59-year-old woman presented in 1983 with typical clinical manifestations of CJD and died 16 months later. Postmortem examination revealed severe neuronal loss, spongiosis and gliosis extensively in cerebral cortex and striatum as well as in the white matter. We also report 6 other CJD patients seen from 1983 to 1991 at Veterans General Hospital-Taipei.

ISSN:0014-3022    

DOI:10.1159/000116945

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

In a 72-year-old woman with a 33-year history of diabetes mellitus bilateral chorea had occurred after a series of hypoglycemic comas at the age of 58. The choreiform movements remained untreated, persisted more than 10 years and inspite of intermittent exaggeration were tolerated by the patient. Except for the hyperkinetic movements, neurological examination of this patient was otherwise normal as was cranial computer tomography.

ISSN:0014-3022    

DOI:10.1159/000116946

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

A benign oligodendroglioma was removed in a young patient who had temporal epileptic seizures. He then became free of any fit until 15 months after the operation, when he developed seizures progressively less controlled by therapy. All investigations were normal (including CT scan and MRI) except a PET study which showed a high uptake of nC-L-methionine in the area of the previous tumor. The second operation revealed that this area was indeed a tumor recurrence. We briefly discuss the potential usefulness of PET for the follow-up of low grade gliomas.

ISSN:0014-3022    

DOI:10.1159/000116947

出版商:S. Karger AG    

年代:1993

数据来源: Karger