摘要:

The clinico-pathological data and the topography of the lesions were determined in 13 cases of late radiation encephalopathy. In one case the arterial vascularisation was studied by the translucidation technique after filling of the blood vessels with a colloidal barium sulphate solution. The radiation lesions consisted of areas of focal necrosis and of diffuse demyelination and necrosis of the deep cerebral structures and the brain stem. Demyelination was predominantly present in cases of late appearance of the neurological symptoms while necrosis was found in cases with a short latency period. The cerebral cortex and the arcuate fibres were always the most preserved structures. The topography of the focal lesions in the cerebral hemispheres and in the brain stem corresponded well to the vascular supply areas of the deep perforating arteries, while the diffuse lesions always had a predominant distribution in the periventricular arterial end- and border-zones. These observations were also confirmed by a post mortem angiographic study. The present report argues once more for a vascular aetiology as cause of the late radiation encephalopathy.

ISSN:0014-3022    

DOI:10.1159/000114704

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

25 Wistar rats were subjected twice daily to epileptic seizures induced by the convulsant gaz Flurothyl. Compared with littermates of the same sex and birth weight, the brain of seizure-treated rats showed a reduction of 6% (5.2 million cells) after 5 days and 17.6% (33.4 million cells) after 10 days of treatment.

ISSN:0014-3022    

DOI:10.1159/000114705

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

43 patients with facial myokymia were examined clinically and electromyographically over periods of up to 13 years. 18 patients were suffering from multiple sclerosis, 6 patients from brain stem tumour or tumours of the posterior cranial fossa, and 19 from other known or unknown neurological disorders. Duration, recurrences, EMG results of myokymia and its accompanying neurological symptoms are described.

ISSN:0014-3022    

DOI:10.1159/000114706

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

In 19 normal adults reserpine administration induced significant changes in the parameters of the second glabellar response (R2): shortening of the latency and duration; decrease of the excitability threshold and complete blockade of the physiological habituation of R2 to the electrical and mechanical stimulation. No changes in the first response (Rl) were observed. All the R2 changes disappeared within about 3 days of drug administration. The Parkinson-like effect of reserpine on the glabellar reflex is discussed in the light of a neurohormonal hypothesis in the control of the polysynaptic pathways biasing R2.

ISSN:0014-3022    

DOI:10.1159/000114707

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

Congenital lesion of the left facial nerve trunk has been investigated in a 30-year-old woman. Upon stimulation of the left facial nerve, no response was evoked in any of the mimic muscles. The patient was able to perform voluntary contractions of the left corrugator glabellae muscle and of the left corner of the orbicular oral muscle; these contractions were recorded electromyographically. The stimulation of the right facial nerve elicited responses in the referred left mimic muscles. This circumstance indicated their activity to be due to contralateral reinnervation by the intact facial nerve. The blink reflex examination evoked no response on the left side, while the blink reflex on the right side was elicited with both its components, both upon ipsi- and contralateral stimulation.

ISSN:0014-3022    

DOI:10.1159/000114708

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

Lumbar CSF concentrations of homovanillic acid (HVA) and 5-hy-droxyindole-acetic acid (5HIAA) have been determined in ten patients suffering from chronic brain post-traumatic syndromes, at various length of time after the brain trauma. Lower concentrations of HVA (mean 21±14 µg/ml) compared to controls (mean 46±10 ,µg/ml) was observed in 7 cases; 5HIAA levels were within normal values. The 5HIAA/HVA ratio (1.59±0.66) was significantly higher (p<0.001) than the one recorded in controls (0.66±0.10). Monitoring of lumbar HVA and 5HIAA over time, before, during and after L-dopa treatment, revealed interesting correlations between modification of clinical picture and the levels of monoamines acid metabolites. The data indicate a profound alteration of brain monoamines in chronic syndromes following a severe head injury and suggest that measurements of lumbar HVA and 5HIAA in these patients may be of euristic and diagnostic

ISSN:0014-3022    

DOI:10.1159/000114709

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

Ventricular concentrations of homovanillic acid (HVA) and 5-hydroxyindole-acetic acid (5HIAA) were measured in 7 patients a few days after a severe traumatic brain injury. Both acid metabolites were elevated in respect to control patients values, however, the rise was more consistent for 5HIAA (258±86 ng/ml) with a 5HIAA/HVA ratio of 0.85±0.35. The data support previous hypothesis on the profound involvement of serotoninergic structures in the early stages of acute traumatic brain syndromes and on the role of 5HT in maintaining edema and vasospas

ISSN:0014-3022    

DOI:10.1159/000114710

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

A case of acute transverse myelopathy with anaesthesia and flaccid paralysis of both lower limbs, following intragluteal penicillin injection, is reported. This accident was probably due to a mistaken intra-arterial injection of the drug with retrograde progression through branches of the internal iliac artery up to the spinal cord. The treatment of such events in all the cases reported by the literature has been disappointing. Therefore, particular precautions must be taken in case of intramuscular penicillin injection, according to the present and the previous cases described, in order to avoid such accidents.

ISSN:0014-3022    

DOI:10.1159/000114711

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

Clonazepam seems to be an effective drug in idiopathic trigeminal neuralgia. Electrophysiological investigations support the idea that this neuralgia is due to a loss of central inhibition. During the first 1–2 weeks of treatment marked drowsiness is observed in the majority of cases. In one case, presence of a synergism between Clonazepam and L-dopa+ inhibitor was also observe

ISSN:0014-3022    

DOI:10.1159/000114712

出版商:S. Karger AG    

年代:1975

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000114713

出版商:S. Karger AG    

年代:1975

数据来源: Karger