摘要:

The urinary excretion of amino acids of 5 migraine patients was studied during as well as between attacks of headache, each patient serving as his own control. Three patients were fasting during study, whereas 2 were allowed to eat. Chromatography of urine was carried out on a Technicon amino acid analyser with chromobead type A resin. The gradient buffer solutions contained sodium or lithium salts. The peaks were measured with Technicon Integrator Calculator. Histamine-like activity in urine was measured with Dunér and Pernow’s method. Generally only small differences between attack and free interval were found in the amino acid pattern, without any systematic trend. This also pertains to lysine and arginine. There were three exceptions to this: histidine excretion was approximately doubled in 1 patient during headache. In another patient, 1-methylhistidine excretion was about 5 times higher during attack than in the free interval. In still another patient, 3-methylhistidine was definitely higher during than between attacks. Even with regard to each of these parameters, however, the 4 remaining patients showed no definite attack-induced difference in excretion. Two patients showed increased excretion of histamine-like activity in the free interval, but normal excretion during attack. These two patients displayed no common trend in histidine, 1-methylhistidine or 3-methylhistidine excretion that differed from that in the 3 patients exhibiting normal excretion of histamine-like activity. It is concluded, that migraine causes no systematic changes in amino acid pattern. This contrasts previous findin

ISSN:0014-3022    

DOI:10.1159/000114421

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

An unilateral oculo-palpebral reflex evoked by weakly tapping the eyeball is described. It has a latency of 8–9 msec and a well-synchronized aspect. It is often followed by a silent period lasting 20–80 msec and is accompanied by a reciprocal inhibitory pause in the homolateral frontal muscle. It is unaffected by local anesthesia of the homolateral supra and infraorbital nerves, but is abolished by a homolateral retrogasserian neurotomy. Our results suggest that this short-latency blink reflex is produced by the stretching of extraocular muscles. It seems, therefore, likely that it originates in extraocular muscle spindles whose primary afferents are known to run with the ophthalmic branch of the trigeminal nerve. This reflex response can be facilitated by voluntary activation of the opposite orbicularis oculi muscle and in spastic hemiplegic patients it is potentiated on the affected side. Stronger tapping of the eyeball evokes a bilateral blink reflex with characteristics of a nociceptive reflex. It is suggested that this reflex originates in pain receptors located in extraocular musc

ISSN:0014-3022    

DOI:10.1159/000114422

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

The present paper reports the case of a 48-year-old patient with a clinical syndrome of dementia, visual disturbances, extrapyramidal disorders and a progressive evolution that lasted 6–8 months. Histological examination revealed reticuloplas- macytosis; this feature together with the clinical and humoral signs suggested a diagnosis of the Bing-Neel syndrome. This may be considered as a primary reticulosis of the brain – which may be distinguished from Kahler’s multiple plasmacytoma and Waldenström’s macroglobulinemia – with the cellular differentation towards plasmacytes. Histologically, the methyl-green pyron-ine staining method is of particular diagnostic value, as it shows the transitional forms between the activated reticulum cell and the mature plasmacyte, and can differentiate between the unripe plasma lymphocytoid cell and the

ISSN:0014-3022    

DOI:10.1159/000114423

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

The association of extrapyramidal syndromes with the clinical picture of intracranial space-occupying processes in children is comparatively rare. Of 757 intracranial space-occupying processes in children treated in the Clinic of Neurosurgery, Bucharest (1944–1969), 9 presented extrapyramidal signs: 5 gliomas, 1 pinealoma, one intraventricular hydatic cyst, one left parietal hydatic cyst, one brain stem tumor not checked histologically. Similar cases in the literature are reviewed, with a brief discussion of certain aspects in the pathogeny of extrapyramidal syndromes caused by intracranial space-occupying processe

ISSN:0014-3022    

DOI:10.1159/000114424

出版商:S. Karger AG    

年代:1972

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000223393

出版商:S. Karger AG    

年代:1900

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000223394

出版商:S. Karger AG    

年代:1900

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000223395

出版商:S. Karger AG    

年代:1900

数据来源: Karger

摘要:

Report of the treatment of meningeal infiltration in a case of acute lymphocytic leukaemia occurring in a 19-year-old male. Neurological recovery persisted during a subsequent fatal systemic relapse. It lasted for 12 weeks and was confirmed at autopsy. Total dose of intrathecal methotrexate was 70 mg. Treatment of CNS infiltration is discussed.

ISSN:0014-3022    

DOI:10.1159/000114425

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

A pair of dizygotic twins suffering from myotonia congenita born in Great Britain, is described. The twins were subjected to genetic, biochemical and electromyographic studies as were 5 relations in three generations. Spina bifida occulta was found in both popositi and is regarded as coincidental. The rarity of a recessive mode of inheritance in myotonia congenita in Great Britain is discussed.

ISSN:0014-3022    

DOI:10.1159/000114426

出版商:S. Karger AG    

年代:1972

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000223396

出版商:S. Karger AG    

年代:1900

数据来源: Karger