摘要:

Five patients exhibited an apparently communicating hydrocephalus – type of disorder, with ventricular reflux on the cisternograms, lack of air-encephalographic parasagittal air-filling and clearly enlarged temporal horns. The group seemed heterogeneous, with regard to age distribution; possible etiological factors and duration of the hydrocephalic process. In all 5 patients increased intracranial/intrathecal pressure was observed: in 2 patients, only with intrathecal measurement in the lumbar area, but in the remaining 3 patients with epidural/ventricular fluid pressure monitoring. Continuously increased pressure extending over 1 or more days was observed in these patients. This pressure increase may seem different from the episodic pressure increase previously reported in normal-pressure hydrocephalus. These patients seem to be cases of so-called normal-pressure hydrocephalus according to the commonly accepted criteria. It is therefore suggested that the term normal-pressure hydrocephalus should be abandoned, and replaced by, e. g., low-pressure hydrocephalus, malresorptive or malabsorptive hydrocephalu

ISSN:0014-3022    

DOI:10.1159/000114738

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000219333

出版商:S. Karger AG    

年代:1903

数据来源: Karger

摘要:

Effects of intrathecal cytostatic chemotherapy on the clinical symptoms and cerebrospinal fluid (CSF) findings are being demonstrated in a case of metastatic carcinoma of the breast with signs of meningeal irritation and cranial nerve involvement. Clinical symptoms disappeared after repeated intrathecal applications of methotrexate. CSF cell counts were reverted to normal but tumor cells were found to be persistant in CSF over a period of 19 months. Risks of combined intrathecal and systemic cytostatic therapy and possible effects of parenteral citrovorum factor applications are being discussed. The importance of continued intrathecal chemotherapy and of regular and thorough examination of CSF cells in meningitis carcinomatosa is emphasized. Cytological methods included investigations on viable CSF cells.

ISSN:0014-3022    

DOI:10.1159/000114739

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000219334

出版商:S. Karger AG    

年代:1903

数据来源: Karger

摘要:

Three cases of primary brain tumors simulating purulent meningitis have been described. Two patients were infants suffering from ependymoma of the posterior fossa, while the third was a 35-year-old man with astrocytoma of the temporal lobe. All cases were characterized by acute onset with fever, signs of meningeal irritation without any other neurological signs, and marked CSF pleocytosis. The diagnosis in 2 cases was made only at necropsy, and the third case was correctly diagnosed only after a delay. The possible occurrence of brain tumor and meningitis simultaneously was considered and seemed unlikely in our cases. A possible explanation for the clinical and CSF findings was irritation of the leptomeninges by the tumor and its breakdown products.

ISSN:0014-3022    

DOI:10.1159/000114740

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

The present paper is the study of a case of progressive multifocal leucoencephalopathy that appeared in the course of a malignant reticulosis accompanied by paraproteinosis. Due to the lesions in the brain stem and cerebellum, the case evolved clinically as a pure cerebellar form. The particularity of the morphologic aspect, not as yet described, was the abundant presence of Rosenthal fibres in the older demyelination foci. These fibres exhibited a typical structure both in the electron and optic microscope. Emphasis is laid on the connection between the formation of Rosenthal fibres and blastic cellular transformation of the glial system.

ISSN:0014-3022    

DOI:10.1159/000114741

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000219335

出版商:S. Karger AG    

年代:1903

数据来源: Karger

摘要:

In the present study, six multiple sclerosis (MS) brain white matter biopsies were analyzed both morphologically and chemically. The purpose of this study was to test the reliability of the earlier postmortem observations. Special attention was given to proteins which were analyzed in polyacrylamide disc gel electrophoresis and to acid proteinase. The results show that myelin basic protein (BP) was present in all biopsies, although advanced demyelination was seen in one case as based on morphology. This finding is controversial to earlier observations. In addition to this, some acid proteins were decreased or lost in two cases. The activity of acid proteinases was increased from two- to fivefold in four of six cases. This increase of the activity was seen also in the normal-appearing MS autopsy white matter which served as control. The source of this activity is discussed. On the basis of the present results it is likely that the role of the BP in the breakdown of myelin in MS and the role of acid proteinases has to be studied in more detail.

ISSN:0014-3022    

DOI:10.1159/000114742

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

The plasma concentration of dopa was studied in 15 parkinsonian patients after a single administration of L-dopa. The study was undertaken in order to determine if correlation between plasma dopa concentration and clinical performance as a result of the tests carried out before and after a single dose of dopa, was present. Our data confirm the absolute absence of correlation between dopa levels in plasma and clinical improvement during long-term treatment. Moreover, clinical responses to the performance tests were not related to the concentration of circulating L-dopa in the plasma. Therefore dopa levels cannot be useful in clinical practice but only for the prevention of too high concentrations of plasma L-dopa which often cause a few side-effects.

ISSN:0014-3022    

DOI:10.1159/000114743

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000219336

出版商:S. Karger AG    

年代:1903

数据来源: Karger