ISSN:0014-3022    

DOI:10.1159/000219450

出版商:S. Karger AG    

年代:1903

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000219451

出版商:S. Karger AG    

年代:1903

数据来源: Karger

摘要:

Two cases of idiopathic orthostatic hypotension are reported, one associated with striato-nigral degeneration (case 1) and the other with Lewy body parkinsonism (case 2). In case 1, cerebrospinal fluid monoamine studies were carried out before and during treatment with 5-HTP and L-dopa. Low values of 5-HIAA appeared to be associated with degeneration of the spinal cord intermedi-olateral column. L-dopa had a beneficial effect on both parkinsonism and hypotension over a period of 6 months. New pathologic observations included changes in the sacral cord and a topographically related involvement of the substantia nigra and striatum, consistent with recent experimental neuroanatomical data.

ISSN:0014-3022    

DOI:10.1159/000114674

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

Two patients with Huntington’s chorea (HC) developed a gait disturbance more suggestive of normal pressure hydrocephalus (NPH) than HC. The diagnosis of NPH was confirmed by pneumoencephalography and isotope cisternography. Both patients were shunted and both showed an improvement not only in their gait but, unexpectedly, a decrease in their abnormal involuntary movements (AIMs). The association of HC with NPH is discusse

ISSN:0014-3022    

DOI:10.1159/000114675

出版商:S. Karger AG    

年代:1975

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000219452

出版商:S. Karger AG    

年代:1903

数据来源: Karger

摘要:

In this study the effects of vincamin (Pervincamine) on cerebral metabolism were investigated. 60 subjects were tested. Vincamin was administrated to 36, aminophillin to 12. No drug was given to the remaining 12 subjects who were used as controls. A definite increase in cerebral metabolism was observed in patients receiving vincamin either by intravenous or intramuscular injection. Practically no change in cerebral metabolism was detected in subjects treated with aminophyllin.

ISSN:0014-3022    

DOI:10.1159/000114676

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

Workable criteria are proposed that allow early recognition of mild forms of occult hydrocephalus and correlated disorders. Two groups of patients are analyzed, i.e. a group of twelve mild but classical forms of low-pressure hydrocephalus and another group of 20 patients with atypical clinical forms of disorders of the CSF dynamics. Two control groups are presented for neuropsychological comparison purposes: a normal control group of 50 subjects and a small group of three commissurotomized subjects. Patients with an overt demential syndrome due to a normotensive hydrocephalus syndrome were excluded from the study. The authors found the grasp reflex of the foot and the tonic foot response to be present in all cases with the Hakim and Adams triad. In such cases the grasp reflex is usually accompanied by the forward groping of the foot and the grasp reflex of the hand. The most helpful and useful clinical findings for an early diagnosis are the presence of the grasp reflex of the foot and of the tonic foot response of the sole in such organic brain-damaged patients with (1) a normal routine neurological examination and (2) an apparently normal mental status and even with a rather normal IQ. These reflexes are usually the single objective clinical findings in all forms of mild and occult disorders of the CSF dynamics, i.e., low-pressure hydrocephalus syndromes, cerebral atrophies and mixed forms cases. The next step for the diagnosis consists in a conventional IQ evaluation and a battery of tests exploring more specifically the sensorimotor integration, i.e. bimanual vs. unimanual activity, the Kohs block design test and part of the Halstead-Reitan neuropsychological test battery. In such patients there is a striking dissociation between a normal or rather normal IQ on the one hand and the results of the neuropsychological evaluation with the Kohs and Reitan tests on the other. The clinical and neuropsychological testings are then followed by isotope cisternography, PEG and EMI-Scan which confirm the presence of the organic brain damage. The recognition of such conditions is of great practical importance because it allows an early diagnosis of the brain damages. Some preliminary data regarding the medical treatment - acetazolamide - are shortly reviewed.

ISSN:0014-3022    

DOI:10.1159/000114677

出版商:S. Karger AG    

年代:1975

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000219453

出版商:S. Karger AG    

年代:1903

数据来源: Karger

摘要:

A case of cerebral aspergillosis in a 69-year-old diabetic man is reported. The disease, initially presenting as headache and vertigo, was caused by Aspergillus fumigatus. Seven CSF specimens were examined. The main findings included decreased glucose and increased protein concentrations, leukocyte reaction and one positive culture for A. fumigatus. Neuropathological examination revealed granulomatous leptomeningitis and typical fungal hyphae. The process probably lasted for more than 1 year and was an important contributing factor to two brain stem infarcts.

ISSN:0014-3022    

DOI:10.1159/000114678

出版商:S. Karger AG    

年代:1975

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000219454

出版商:S. Karger AG    

年代:1903

数据来源: Karger