摘要:

A patient with monosialoganglioside accumulation in the brain is described who shows a clinical onset of the disease at 1 year of age, no visceromegaly nor skeletal X-ray changes. There is no ganglioside accumulation in the liver. These observations permit a clear distinction from the generalized GM1 gangliosidosis and agree with the division in 2 types as proposed by Derry. There was no β-galactosidase activity in the liver and the leukocytes of the patients but in the brain this enzyme showed an only slightly reduced activity. The leukocytes of the parents and of 4 of their 10 brothers and sisters showed a marked reduction of the β-galactosidase activity, suggesting an heterozygous stat

ISSN:0014-3022    

DOI:10.1159/000114034

出版商:S. Karger AG    

年代:1970

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000228730

出版商:S. Karger AG    

年代:1898

数据来源: Karger

摘要:

The association of multiple sclerosis (MS) with infections has been studied in two projects. First, the geographical distribution of MS in Finland has been compared with the areal incidence of 7 childhood infections, rheumatic fever and tuberculosis during several periods. No typical and significant correlations could be noticed. Secondly, the infectious history and serum hemagglutination antibodies against measles in a MS group and a group of matched controls in South-Western Finland were studied. The frequency of the different infections was evenly distributed between the groups. However, the MS sera had significantly higher antibody titres.

ISSN:0014-3022    

DOI:10.1159/000114006

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

Transorbital sonoencephalography offers the possibility of demonstrating parieto-occipital tumors as well as posteriorly located chronic subdural and epidural hematomas. The technique used by the author in preliminary studies is described.

ISSN:0014-3022    

DOI:10.1159/000114007

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

The influence of 1-(3-methylaminopropyl)-di-benzo[b,e]-bicyclo-[2,2,2]octadiene hydrochloride (preparation Ciba 34,276-Ba) on the cortical EEG was studied in 50 healthy volunteers of both sexes aged between 20 and 45 years. EEG tracings were recorded before medication, and then on two consecutive days of treatment with 3 x 50 mg daily, i.e. after total doses of 150 and 300 mg. The percentages, frequencies and amplitudes of the α-waves in each of the three tracings were determined and compared. Quotients of the wave percentages, frequencies and amplitudes for the occipital/frontal, occipital/parietal and parietal/frontal brain regions were calculated. The tracings were examined for slower or faster waves and specific seizure activity. The clinical picture was taken into consideration. The results indicate that the preparation exerted an activating effect on the α-waves with a slight tendency towards synchronization and slowing. The differences became more pronounced after further treatment. Clinical signs of tranquillization and occasional psychomotor retardation were observed. Signs of tiredness were seen in some cases after the first dose, but these did not recur with further medication. No arousal effect was evident. It is assumed that the preparation acts via the limbic moderator and stimulates the components responsible for synchronizing the EEG and stabilizing psychic activity. The effect of short-term, controlled administration of the trial substance on the cortical EEG of healthy persons differs in a positive sense from that of other antidepressants. Detailed evidence in support of this finding will be presented in a later communicatio

ISSN:0014-3022    

DOI:10.1159/000114008

出版商:S. Karger AG    

年代:1970

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000228732

出版商:S. Karger AG    

年代:1898

数据来源: Karger

摘要:

A case of cataplexy with simultaneous EEG recording in a 37-year-old man is reported in which the patient suffered attacks of weakness, facial twitching and wild dreams. Dreams frequently accompanied the onset of sleep. The EEG correlated with the clinical picture in that the normal alpha-rhythm underwent flattening and then a typical paradoxical sleep pattern occurred. All-night sleep EEG showed immediate onset of REM sleep with zero latency. In addition there was instability with prevalence of the light sleep phase over deep sleep, prolonged awakening and an increase in the amount of REM sleep. Under medication with imipramine (30 mg/day) the patient experienced no cataplectic attacks and could return to work.

ISSN:0014-3022    

DOI:10.1159/000114009

出版商:S. Karger AG    

年代:1970

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000228733

出版商:S. Karger AG    

年代:1898

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000114010

出版商:S. Karger AG    

年代:1970

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000228734

出版商:S. Karger AG    

年代:1898

数据来源: Karger