ISSN:0014-3022    

DOI:10.1159/000219249

出版商:S. Karger AG    

年代:1904

数据来源: Karger

摘要:

A family with myotonia congenita without cold paralysis in 26 affected members is described. Cold paralysis never occurred spontaneously in this family and could not be provoked by immersion in ice water or by K+ load. The findings confirm the existence of paramyotonia without cold paralysis as a separate genetic entity.

ISSN:0014-3022    

DOI:10.1159/000114781

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

99 patients with late epilepsy were investigated in our EEG laboratory. In intervals of maximal 100 days (average 23 days) a waking EEG recording and a CTAT were carried out. The average age was 43. 62.5% of the pathological CTATs were found in partial seizures with elementary symptomatology. In patients with generalized seizures the diagnosis of symptomatic epilepsy could be made in 20 cases (34 %) with the help of computerized tomography. Generalized seizures were related to tumors only in 8.5 % in our case material. In 20 of 99 EEGs in our patients there was a continuous delta wave focus, 12 of these with epileptogenic activity. Of these 20 patients, 18 showed a pathological result in computerized tomography. Eight tumors or metastases, 8 cases of atrophy (7 local and 1 diffuse) as well as 1 case of encephalitis could be diagnosed. 12 EEGs showed continuous or intermittent theta wave foci. Computerized tomography never gave a pathological finding in these patients. If one compares the results of CTAT and EEG in cases of tumor, the agreement between positive tomography and the pathological EEG is very high (97 %): 33 positive CTATs compared with 31 positive EEGs. Our investigations with computerized tomography show organic findings in 34 of 99 epilepsies, that is about 34 %.

ISSN:0014-3022    

DOI:10.1159/000114782

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

18 newborn rats received two electroshock seizures daily for 10 days. Their neurochemical and behavioral development was compared to that of littermates of the same sex and similar weight, which were either untreated or treated with the same total amount of electrical current at subconvulsive intensities. While the two control groups were behaviorally or neurochemically indistinguishable, experimental rats reached several behavioral milestones (swimming, free-fall righting, auditory startle, visual placing) significantly later than controls and had smaller brains, containing significantly less DNA, protein or cholesterol than either control group. This study demonstrates that in the rat neonatal seizures are followed not only by impaired neurochemical development of the brain but also by delays in the animal’s behavioral developmen

ISSN:0014-3022    

DOI:10.1159/000114783

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000219250

出版商:S. Karger AG    

年代:1904

数据来源: Karger

摘要:

An assay of antibodies to 15 various viruses and mycoplasma pneumoniae was performed on the serum specimens from 441 patients with Parkinson disease and from 443 healthy controls matched by sex, age, and place of residence, or from a representative group of these matched pairs. The main finding was a higher herpes simplex complement-fixing antibody level in patients with Parkinson disease than in controls. Patients with Parkinson disease had higher herpes simplex antibody titers more often than did their matched controls, and the matched controls, respectively, had low titers more often than the patients. The mean herpes simplex antibody titer (log2) of the patients (4.9) was significantly higher than that of controls (4.6) (p < 0.01). This difference was also demonstrable when matched pairs were analysed for paired differences of herpes simplex antibody titers. For other viral CF and HI antibodies studied and for mycoplasma pneumoniae CF antibody, there were no significant differences either in the mean titers or in the distribution of individual titer values between the patients with Parkinson disease and the matched controls.

ISSN:0014-3022    

DOI:10.1159/000114785

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000219251

出版商:S. Karger AG    

年代:1904

数据来源: Karger

摘要:

The speech of three groups of Parkinson patients – nonsurgical, postunilateral and postbilateral thalamotomy – was evaluated. Dysarthria, bulbar motility and pyramidal tract indexes were determined for each patient. There was a statistically significant greater impairment in dysarthria and pyramidal tract indexes of patients with thalamotomy. L-Dopa and carbidopa therapy failed to significantly improve speech in any gr

ISSN:0014-3022    

DOI:10.1159/000114786

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The CSF γ-globulin patterns found by electrofocusing in multiple sclerosis can be classified into five (a–e) mean patterns, where the individual bands lie very close together. However, in some patients with verified or probable multiple sclerosis conspicuous bands are found. The electrofocusing patterns from 28 such cases were compared with those reported by Kjellin and Vesterberg and with 20 cases of verified multiple sclerosis collected by chance. Differences were found with regard to the frequency of the different mean patterns, the occurrence of a double fraction in region ‘5’, a single fraction in region ‘7’ and a highly alkaline fraction. The electrofocusing findings have been compared with the clinical data of the 28 patients. There seems to be some correlation between the patterns of conspicuous bands and the duration and course of the disorder as well as probable sites of the CNS lesions. No indication was found, that either a high CSF γ-globulin value and/or a high degree of barrier damage was a prerequisite for the occurrence of conspicuous bands in the CSF γ-globulin region. The aberrant electrofocusing patterns might be genetically determined or caused by some unusual agents (possible viral) or autoimmune reactions, modified by other than genetically diver

ISSN:0014-3022    

DOI:10.1159/000114787

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000219252

出版商:S. Karger AG    

年代:1904

数据来源: Karger