摘要:

A case of Seitelberger’s infantile neuroaxonal dystrophy is reported. The histopathological features comprise a large amount of axonal spheroids, mainly in the gray matter of the CNS, associated with complex systemic degenerations involving the long tracts, the visual system, the cerebellum and the basal ganglia. The pathological picture of the disease is essentially that of a dying back degeneration involving several fiber tract systems and the spheroids represent a peculiar alteration of terminal axons and nerve endings of the involved system

ISSN:0014-3022    

DOI:10.1159/000114241

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

The epileptogenic property of ouabain was studied in cats including 17 chronic and 13 acute animals. In chronic experiments, infusion of ouabain into the septum by means of an indwelling cannula induced severe rhinencephalic epileptic state followed by a long lasting spike activity in the hippocampus. Several mechanisms responsible for such a self-sustained epileptic activity are discussed by considering the specific metabolic action of ouabain and the site of injection. Intraventricular infusion of 20 µg ouabain, induced a loss of intracellular potassium demonstrated by an increase of potassium concentration in CSF which is followed by a cerebral hyperemia determined by 133 Xe clearance method and later by an epileptic state in the hippocampus. The change in cerebral ionic distribution is considered as a causal factor of both cerebral hyperemia and epileptic activity. The influence of the preconvulsive increase of the cerebral blood flow upon the peculiar intensity of epilepsy induced by ouabain is suspected. From these results the role of potassium in regulating electrical activity and cerebral blood flow and their interrelationship of the latter is emphasized

ISSN:0014-3022    

DOI:10.1159/000114242

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Concentrations of homovanijlic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in the cerebrospinal fluid (CSF) were studied before and during treatment of 151 parkinsonian patients with levodopa alone or combined with a decarboxylase inhibitor. A particular attempt was made in this study to determine whether any correlation exists between the concentrations of these acid monoamine metabolites in the CSF before and during treatment as well as after administration of probenecid and the therapeutic response and side-effects of the treatment. In patients with Parkinson’s disease the concentrations of HVA and 5-HIAA in the CSF before therapy and after administration of probenecid were found to be significantly lower than those in control subjects. Statistical analyses showed that these variables could not be used to predict the clinical response to treatment. Long-term treatment with levodopa alone or combined with a decarboxylase inhibitor induced an increase in the concentration of HVA in the CSF which correlated significantly with the dose of the drug but not with the clinical improvement. However, the concentrations of HVA during combined treatment were considerably lower than during treatment with levodopa alone, using therapeutically equivalent dosages. Obviously, a part of the HVA found in the CSF during levodopa treatment originates from the brain capillary walls. Treatment with levodopa and decarboxylase inhibitor decreased the concentration of 5-HIAA in the CSF. During treatment with levodopa alone, there was a significant negative correlation with the dose of levodopa as well as with libido and psychotic behavior after 6 and 12 months’ treatment, respectiv

ISSN:0014-3022    

DOI:10.1159/000114243

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Two muscle biopsies were made in a case of chloroquine neuromyopathy in a 57-year-old woman with discoid lupus erythematosus. Histological study demonstrates widespread granulovacuolar degeneration and alterations of terminal innervation. Ultrastructural changes include formation of myelin figures and autophagic vacuoles. Of particular interest is the amount and mode of recovery from such alterations 2 months after cessation of the treatment.

ISSN:0014-3022    

DOI:10.1159/000114244

出版商:S. Karger AG    

年代:1973

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000114245

出版商:S. Karger AG    

年代:1973

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000221425

出版商:S. Karger AG    

年代:1901

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000221426

出版商:S. Karger AG    

年代:1901

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000221427

出版商:S. Karger AG    

年代:1901

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000221428

出版商:S. Karger AG    

年代:1901

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000221429

出版商:S. Karger AG    

年代:1901

数据来源: Karger