摘要:

The most important perinatal encephalopathies, which are caused by diseases of the mother during pregnancy, comprise brain damage due to malnourishment and some inherited metabolic diseases, dysthyroidism and diabetes, infectious diseases, hypoxic circulatory disturbances and kernicterus. Besides the brain alterations directly caused by these conditions, changes of a secondary nature are discussed. These are mainly due to curtailed or perverted maturational and late developmental processes. The end-result thus will be a complex of primary and secondary changes and the type and distribution of alterations are dependent not only upon the nature of the harmful factor but also on the time of its operation.

ISSN:0014-3022    

DOI:10.1159/000114427

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

While examining a patient with myotonia congenita, it was found that stimulation of the ulnar nerve with frequencies of 5 or 8 cps caused the amplitude of the muscle action potential to decrease rapidly to the base line. During the following lapse, the muscle was paralyzed. After about 20 sec the amplitude increased again, and the strength of the muscle returned. This temporary paresis is apparently of importance in the genesis of myotonic impediment to motility. Probably the disturbance is located in the muscle fibre. Very little information on this subject is available in the literature.

ISSN:0014-3022    

DOI:10.1159/000114428

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

Treatment of Parkinson’s disease with amantadine and L-dopa was studied in 82 patients. A double-blind cross-over trial with 38 patients showed a significant benefit with 200 mg of amantadine daily. During non-blind treatment with 300 mg of amantadine for 2–4 months 60% of the patients showed moderate or marked overall improvement. The results were independent of age, sex, duration or severity of the disease or previous thalamotomy. During combined treatment an additive effect of L-dopa, but not that of amantadine, was demonstrated showing that the therapeutic effect of L-dopa is superior to that of amantadine. Furthermore, an increased number of clinical side-effects, especially nausea and vomiting were found during combined treatment. Moreover, the response to L-dopa could not be predicted with amantadine. Amantadine treatment did not induce changes in the concentration of HVA and 5-HIAA in the CSF although there is a strong evidence of a monoamine-releasing effect of amantadine on experimental anim

ISSN:0014-3022    

DOI:10.1159/000114429

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

Described is a case of peripheral neuropathy secondary to essential cryoglobulinemia. This complication of the disease is exceptional. One month prior to admission, a 28-year-old woman complained of paresthesias in the distal parts on her limbs; this was followed by impairment of sensation, with difficulties in standing and walking. Finally, there was an almost total loss of motion of the fingers of both hands. The clinical picture and laboratory studies demonstrated a damage of the nerve trunks, of equal intensity in the arms and the left leg. In the right leg it was less marked. The cryoprecipitate was composed of IgG and IgM. The possible mechanisms of the immunological reactions, and the pathogenesis of the neurological manifestations are discussed.

ISSN:0014-3022    

DOI:10.1159/000114430

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

Relations between reading disturbances and oculomotor disturbances are discussed. It is shown that disorders of eye movements may produce reading disturbances in different ways. By comparison, some clinical observations of reading difficulties in the presence of oculomotor disturbances are reported from the literature. The difficulty in separating the oculomotor factors from the semantic factors involved in reading is stressed, normal reading being possible within a wide range of eye movement patterns. It is questioned whether a reliable conclusion on the cause of a reading disability can be based only on the knowledge of eye movement patterns during reading.

ISSN:0014-3022    

DOI:10.1159/000114431

出版商:S. Karger AG    

年代:1972

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000223400

出版商:S. Karger AG    

年代:1900

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000223401

出版商:S. Karger AG    

年代:1900

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000223402

出版商:S. Karger AG    

年代:1900

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000223403

出版商:S. Karger AG    

年代:1900

数据来源: Karger

ISSN:0014-3022    

DOI:10.1159/000223404

出版商:S. Karger AG    

年代:1900

数据来源: Karger