摘要:

The Giemsa banding patterns in the chromosomes of 12 cat species, all previously studied with conventional techniques, have been compared. Although the basic banding pattern is largely similar among the species, several species possess distinctive banding features. Banding has permitted identification of three, rather than two, types of F-group chromosomes and has revealed that the C3 chromosome in two species is the equivalent, by banding pattern, of the F2 and F3 chromosomes in other species. The banding pattern of the X chromosome is similar among all 12 felid species and is also similar to that of the other mammalian species with “original-type” submetacentric X chromosomes which have been studied in this laborat

ISSN:1424-8581    

DOI:10.1159/000130481

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

We have used banding techniques to study the chromosomes of mice heterozygous for two genetically defined paracentric inversions, In(l)lRk and In(2)5Rk. The banding patterns of each inversion-carrying chromosome had an inverted region, and the relative lengths of the genetically and cytologically defined segments were comparable.

ISSN:1424-8581    

DOI:10.1159/000130482

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

An unusually long secondary constriction on chromosome 9 was shown by C-staining to involve duplication of heterochromatin in this region. The constriction stained darkly following the C-staining procedure but was unstained following the G-staining procedure. The heterochromatic constriction generally completed DNA replication earlier than the remainder of chromosome 9. The abnormal chromosome was detected in 17 individuals belonging to three generations of a family. There were twice as many carriers as noncarriers. Similar excesses of carriers were noted in two other pedigrees reported in the literature. Disturbed segregation of this abnormal chromosome 9 is suggested and is consistent with the increased centromeric heterochromatin present. No linkage to chromosome 9 was demonstrated, but Rh-linkage was discounted.

ISSN:1424-8581    

DOI:10.1159/000130483

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

When metaphase chromosomes prelabeled with 3H-thymidine are treated with various C-banding procedures, autoradiographs show a significant amount of DNA loss in the euchromatic segments. The constitutive heterochromatin (C-positive areas) retain most of their label. G-band production following the trypsin procedure, however, does not indicate DNA loss.

ISSN:1424-8581    

DOI:10.1159/000130484

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Fanconi’s anemia is characterized by an increased amount of chromosome breaks. The distribution of the breaks in the human karyotype was analyzed in chromosome preparations, stained for G-bands, from lymphocyte cultures of five patients with Fanconi’s anemia. The results showed a remarkable nonrandom distribution of breaks. All the breaks were located at the lightly stained chromosome segments. There was a clear clustering of breaks at some chromosome loci, such as 3q27 and 13q32. Relative lengths of the chromosome regions (Paris Conference, 1971) were measured from karyotypically normal cells, and the distribution of breaks in regions was analyzed statistically. The distal regions of the A-group chromosomes, particularly, showed an excess of breaks, whereas the centromeric areas had fewer breaks. The sex chromosomes had a deficit of bre

ISSN:1424-8581    

DOI:10.1159/000130485

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

A fertile, tertiary trisomic female mouse, daughter of a Harwell-bred T70H female, produced fertile male and female tertiary trisomics in an outcross to a Swiss random-bred male. Morphologically recognizable and nonrecognizable 41-chromosome male and female progeny were obtained. In the morphologically recognizable animals, the most obvious abnormality was a malformation of the bones of the skull. Fertility of the tertiary trisomic sons was impaired. Conception rate amounted to 29 %, and an average litter size of 3.33 + 1.73 (N = 18) was recorded.

ISSN:1424-8581    

DOI:10.1159/000130486

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Numerical and structural variants (47,XXX; 92,XXXX; 47,XYY; 92,XXYY; 92,lh+lh+) were used to determine the topography of chromatins of different molecular composition in cultivated fibroblast-like cells. In postlogarithmic populations of interphase nuclei, the statistical patterns of chromocenter distributions of 2n and 4n strains were similar, as were the principal modes of the lh+ and X strains. A different pattern was obtained for the pair of Y bodies, and there were classes with intimate associations of chromocenters in both the Y and lh+ strains. It appears that (1) “ectopic pairing” involves specific chromosomes by virtue of segments of constitutive heterochromatin; (2) certain chromosomes are attracted to nuclear structures such as the nuclear margin (inactive X) or the nucleolus (Y), whereas others are not (lh+); and (3) homeologous genomes tend to remain segregated in euploid nuclei of tetraploid cultures; observations on the behavior of the lh+ homeologs during nuclear division were consistent with this interpretation, but quantitation at mitosis may be difficult with human mater

ISSN:1424-8581    

DOI:10.1159/000130487

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

A standard nomenclature for chimpanzee chromosomes is proposed, based on banding patterns and measurements. Comparison of chromosome lengths suggests that the total amount of chromosome material is approximately the same in the human and chimpanzee. Correlation of banding patterns and measurements confirm that the chromosomes of the two species differ by rearrangement of heterochromatic material, several pericentric inversions, and at least one translocation.

ISSN:1424-8581    

DOI:10.1159/000130488

出版商:S. Karger AG    

年代:1973

数据来源: Karger

ISSN:1424-8581    

DOI:10.1159/000130489

出版商:S. Karger AG    

年代:1973

数据来源: Karger

ISSN:1424-8581    

DOI:10.1159/000130490

出版商:S. Karger AG    

年代:1973

数据来源: Karger