摘要:

Centromere-center distances were analyzed in 50 normal female and 100 normal male metaphases. Compared with the random distribution of all chromosomes, chromosome pair 6 had a significantly different distribution in both female and male metaphases. Moreover, a significant peripheral location of chromosome pairs 4 and 5 and a significant central location of chromosome pairs 13, 15, 21, and 22 were found in male metaphases. But no specific peripheral location could be assigned to the X or Y chromosomes. No inter- nor intraindividual differences or sex-dependent variation in centromere-center distances were observed. Variance analyses demonstrated consistent centromere-center distances in normal human metaphases obtained from individuals of the same age. The constancy of these chromosome distributions may correlate with chromosome duplication pattern, chromosome length, and chromosome structure.

ISSN:1424-8581    

DOI:10.1159/000130749

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Bone-marrow metaphases in a 63-year-old male with newly discovered chronic myelocytic leukemia (CML) showed a complex translocation involving chromosomes 9, 11, and 22. About half of the short arm of chromosome 11 was translocated to the terminal part of the long arm of chromosome 9, and the missing fragment on chromosome 22 was translocated to the short arm of the abnormal chromosome 9. The clinical features were typical of CML, and the patient is in good physical condition 10 months after diagnosis on a regimen of busulfan.

ISSN:1424-8581    

DOI:10.1159/000130750

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

One hundred-and-two 13- to 18-day blastocysts were collected from 98 Scottish Blackface ewes mated to one of four New Zealand Romney rams heterozygous for the Massey I (t1) translocation. The karyotype of 75 blastocysts was established, of which 22 were 54, XY, 18 were 54, XX, 20 were 53, XY, t1, and 15 were 53, XX, tι. It is suggested that these results indicated that there was no increase in embryonic loss in ewes mated to rams heterozygous for the Massey I (t1 translocation and that the unbalanced secondary spermatocytes in heterozygous males probably did not mature to spermatozoa

ISSN:1424-8581    

DOI:10.1159/000130751

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Nonrandom associations between the short arms of the sex chromosomes of six Trichosurus vulpecula were studied in 455 cells from the spleen and bone marrow. The association occurs in both sexes and was found to be independent of age. There was, however, a significant difference in the degree of association between the two tissues studied. Regions of constitutive heterochromatin were found to be located in the short arms of the X and Y chromosomes by using a C-banding technique. Nucleolar organizers were detected in the middle of the long arm of the X chromosome and in the short arm of the Y chromosome by N-banding. These results indicate that the nonrandom association of the sex chromosomes may reflect an association between heterochromatin regions during interphase of the cell cycle.

ISSN:1424-8581    

DOI:10.1159/000130752

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Nineteen “female” Holstein-Friesian calves born co-twin with a bull were purchased shortly after birth. One subsequently was judged to be a normal female with 0 % XY (100 % XX) karyotypes in cultures of blood lymphocytes. However, one typical freemartin also had 0 %XY (100 % XX) karyotypes in 300 cells when examined at three ages. Overall, 18 freemartins examined at 1, 24, and 52 weeks of age averaged 60.7 %, 57.9%, and 55.5 % XY cells, respectively (P > 0.05). No systematic relationship was found between the proportion of XY cells and the abnormalities of the reproductive organs, as judged by vaginal depth and clitoral development at 1, 24, and 52 weeks, and examination of the reproductive organs per rectum at 54 weeks of age. The clitoris of untreated freemartins and those treated with estrone or estradiol postnatally did not enlarge. Testosterone treatment caused enlargement. None of the hormones affected vaginal depth. These studies provide convincing evidence that the blood lymphocyte XX:XY karyotype ratio (1) is not related to the degree of masculinization and (2) is stabile in the postnatal freemartin. Thirdly, the freemartin reproductive organs do not respond to common sex-steroid hormones postnatally other than the clitoral response to testoster

ISSN:1424-8581    

DOI:10.1159/000130753

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:1424-8581    

DOI:10.1159/000130754

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:1424-8581    

DOI:10.1159/000130755

出版商:S. Karger AG    

年代:1977

数据来源: Karger