摘要:

Flattened metaphase figures were obtained by squashing or air-drying cells from human leucocyte cultures that had been treated with colchicine and hypotonic sodium citrate prior to fixation. In such metaphase figures the Y chromosome was at the periphery of the figure more often than chance expectation and more often than the chromosome pairs 1, 2, or 16 or the chromosome groups 13–15, 17–18, 19–20, or 21–22. The Y chromosome was further from the center of circular metaphase figures than the mean value of all the chromosomes or the chromosome pairs 1, 2, or 3 or the chromosome groups 4–5, 6–12+X, 19

ISSN:1424-8581    

DOI:10.1159/000129760

出版商:S. Karger AG    

年代:1963

数据来源: Karger

摘要:

Fluctuations in the frequency of sex appendages in the polymorpho-nuclear neutrophil leucocytes were studied in 10 women at different phases of the menstrual cycle. These fluctuations, which are statistically significant, seem to show that the proportion of sex appendages depends on hormonal factors acting during the menstrual cycle.

ISSN:1424-8581    

DOI:10.1159/000129761

出版商:S. Karger AG    

年代:1963

数据来源: Karger

摘要:

The incidence of drumsticks and of sessile nodules as well as the lobe counts of the neutrophil nuclei have been studied in three patients with XXX and three patients with XXXY chromosomes. Three patients with XXY Kline-felter’s syndrome, six apparently normal women and one male were used as controls. The patients with chromosomal abnormalities had on an average a lower incidence of drumsticks and a lower mean lobe count than the controls with normal chromosomes. The incidence of sessile nodules appeared to be increased in the patients with XXX and XXXY chromosomes, but not in those with XXY Klinefelter’s syndrome. It is suggested that in patients with three X chromosomes, the additional X, although unable to form more drumsticks owing to an inhibition of nuclear segmentation, may express itself in a higher incidence of sessile nodules. It is further suggested that an inhibition of segmentation of the neutrophil nuclei associated with a lowering in the number of drumsticks may be a common feature in patients with chromosomal abnormalit

ISSN:1424-8581    

DOI:10.1159/000129762

出版商:S. Karger AG    

年代:1963

数据来源: Karger

摘要:

A satellited submetacentric chromosome, replacing one of the acrocentric members of the 13–15 group, was found in an apparently normal human female and her father; their karyotypes were otherwise normal. The aberrant chromosome is interpreted as likely to have arisen as a result of a pericentric inversion in one of the long acrocentrics. A small duplication is possibly also involved since the altered chromosome is larger than any of the normal long acrocentrics in the complement. Since the proposita was discovered in a survey of karyotypes of apparently normal individuals, the frequency of autosomal aberrations in “normal” human populations is discussed with respect to our own observations and those of other investig

ISSN:1424-8581    

DOI:10.1159/000129763

出版商:S. Karger AG    

年代:1963

数据来源: Karger

摘要:

Cytological studies of a fully-grown Rhode Island Red chicken (Gallus domesticus) with ambiguous sexual characteristics revealed a triploid chromosome constitution with two Zs (3A-ZZ). While this bird had the left oviduct and right rudimentary gonad of a normal hen, the left gonad was like an ovotestis with a sharply defined cortex and medulla. In the cortex were embryonic ovigerous cords containing oöcytes in first meiotic prophase; those oöcytes which had reached dictyotene and formed primordial follicles were degenerative. In the medulla were well-developed seminiferous tubules, a few of which contained sperm heads, although in most spermatocytes, meiosis had not proceeded very far. No diploid cells were found in squash preparations of spleen, bone marrow, or gonad; both somatic cells and germ cells were triploi

ISSN:1424-8581    

DOI:10.1159/000129764

出版商:S. Karger AG    

年代:1963

数据来源: Karger

摘要:

A case of a chromatin positive, mentally deficient 51 year old male who is clinically an example of Klinefelter’s syndrome and has a sex chromosome constitution of XXYY is described. He has some of the features of the four cases previously described by Muldal et al. (1962), Carr et al. (1961), Ellis et al. (1961) and Vague et al. (1961), but also has abnormalities of the serum mucoproteins and the urine chondroitin sulphate levels and very prominent frontal sinuses. The possible aetiology of the chromosome, biochemical and x-ray abnormalities are discusse

ISSN:1424-8581    

DOI:10.1159/000129765

出版商:S. Karger AG    

年代:1963

数据来源: Karger

ISSN:1424-8581    

DOI:10.1159/000129766

出版商:S. Karger AG    

年代:1963

数据来源: Karger