摘要:

The distribution of constitutive heterochromatin (C-banding) in the genomes of nine species of Felidae, one species of Mustelidae, two species of Procyonidae, one species of Viverridae, one species of Canidae, and one species of Ursidae has been studied. In the chromosomes of several felid species the C-band is apparently absent. A few chromosomes show only telomeric staining in one arm or sometimes in both arms. Centromeric and interstitial distribution of heterochromatin has also been demonstrated in other species of Carnivores, but, in general, the C-banded material in felids is comparatively less in amount, and more weakly staining, than in other mammals. Induction of C-banding patterns in certain carnivore species is rather difficult, probably because of the minimal amount of heterochromatin present.

ISSN:1424-8581    

DOI:10.1159/000130770

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Regional localization studies of genes coding for human PGD, PPH1, PGM1, UGPP, GuK1, Pep-C, and FH, which have been assigned to chromosome 1, were performed with man-Chinese hamster somatic cell hybrids. Informative hybrids that retained fragments of the human chromosome 1 were produced by fusion of hamster cells with human cells carrying reciprocal translocations involving chromosome 1. Analysis of the hybrids that retained one of the translocation chromosomes or de novo rearrangements involving the human 1 revealed the following gene positions: PGD and PPH1in 1pter→1p32, PGM1in 1p32→1p22, UGPP and GuK1in 1q21→1q42, FH in 1qter→142, and Pep-C probably

ISSN:1424-8581    

DOI:10.1159/000130771

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The position of genes coding for PGD, PPH1, UGPP, GuK1 PGM1, Pep-C, and FH on human chromosome 1 was investigated by analysis of karyotype and enzyme phenotypes in man-Chinese hamster somatic cell hybrids carrying aberrations involving chromosome 1. Suitable hybrid cell lines were obtained by X-irradiation of hybrid cells carrying an intact chromosome 1 and by fusion of human cells from a clonal population carrying a translocation involving chromosome 1 with Chinese hamster cells. The latter human cell population had been isolated following X-irradiation of primary Lesch-Nyhan fibroblasts. In addition, products of de novo chromosome breakage in the investigated hybrid lines were utilized. By integrating the results of these analyses with earlier findings in our laboratory, the following positions of genes are deduced: PGD and PPH1 in 1q36→1q34; PGM1 in 1p32; UGPP in 1q21→1q23; GuK1 in 1q31→1q42; Pep-C in lq42; and FH in 1qter

ISSN:1424-8581    

DOI:10.1159/000130772

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:1424-8581    

DOI:10.1159/000130773

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:1424-8581    

DOI:10.1159/000130774

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:1424-8581    

DOI:10.1159/000130775

出版商:S. Karger AG    

年代:1977

数据来源: Karger