摘要:

SUMMARYNine patients with extensive pityriasis alba were studied using histopathological and histochemical techniques and electron microscopy. There was a reduction in the density of functional mclanocytes in the affected areas without any change in their cytoplasmic activity. The melanosomes tended to be fewer and smaller, but their distribution pattern in the keratinocytes was normal. Melanosomal transfer to keratinocytes was generally not disturbed. The histology was non‐specific. Hyperkeratosis and parakeratosis were not consistently present, and it seems unlikely that they played a significant role in the pathogenesis of the hypomelanosis. A variable degree of intercellular oedema and intracytoplasmic lipid droplets were present. The hypopigmentation may thus be due primarily to the reduced numbers of active melanocytes and a decrease in number and size of melanosomes in the affected ski

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1983.tb04582.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SUMMARYThe pharmacokinetics of dapsone (DDS) and monoacetyldapsone (MADDS) following an oral dose of 150 mg DDS were studied in sixteen patients with dermatitis herpetiformis and seven normal subjects. No differences in DDS disposition were observed between the two groups. The maintenance dose of DDS for individual patients was not significantly correlated with jejunal biopsy morphology, DDS or MADDS half‐lives, or the area under the plasma concentration‐time curves for DDS or MADDS. DDS plasma protein binding was normal in patients and did not apparently determine the concentration of DDS in skin biopsies, for which the skin/plasma DDS concentration ratio was approximately unity. There was no undue representation of acetylator phenotype in the patient group and no correlation between maintenance dose and MADDS/DDS ratio was noted. The determinants of the maintenance DDS dose have not been found. This may relate to pharmacodynamic differences, but alternatively the concentration of oxidative metabolites rather than DDS or MADDS could be responsible for the therapeutic activity of DDS in dermatitis herpetifor

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1983.tb04583.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SUMMARYWe describe three cases of Sweet's syndrome which showed very rapid improvement with colchicine.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1983.tb04584.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SUMMARYThe activity of phospholipase A2was measured in uninvolved psoriatic epidermis and normal epidermis. The mean phospholipase A2activity in uninvolved psoriatic epidermis, expressed as nmol fatty acid released per mg protein per h, was raised compared with normal epidermis (7.88±s.e. 1·20 vs 2.18±s.e. 0·38; P<0·01). This observation is, we believe, the first demonstration of an abnormality in the uninvolved untreated psoriatic epidermis which could account for the pathology of the dis

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1983.tb04585.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1983.tb04586.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1983.tb04588.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1983.tb04589.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

book reveiw in this articleBaltimore/London:Lymphoproliferative Diseases of the Skin. Edited by M.Goos and E.ChristophersProgress in Diseases of the Skin. Volume 1. Edited hy Raul Fleischmajer

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1983.tb04590.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY