摘要:

SummaryFive young male patients with HIV‐associated Kaposi's sarcoma (KS) were treated with recombinant interferon α 2a (rIFN‐α‐2a) over a period of 2–2.5 years. An IFN dose of 18x106IU was given subcutaneously every day during the first 3 months of treatment and then on alternate days. Additional treatment with radiotherapy and laser therapy was given and, in some cases, isolated skin nodules were excised. Within 7 months of initiation of therapy one patient had a complete remission of his tumours, however, tumour progression recurred after the patient discontinued treatment. In another patient the tumour cleared within 9 months of rIFN therapy, and after 52 months he is still free of KS. The condition of a third patient tended to become stabilized during the first 6 months of therapy, but after 60 months there has been a slow progression. The fourth and fifth patients died 25 and 28 months, respectively, after the histological diagnosis of KS and the initiation of treatment. While on therapy with rIFN‐α‐2a, no life‐threatening opportunistic infections occurred. The side‐effects were mostly well tolerated, and no severe changes in haematological parameters were ca

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1991.tb03283.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

SummaryIn the present study various factors which contribute to the initiation of lesions in dermatitis herpetiformis (DH) were examined. Thirty‐one patients with DH. seven with bullous pemphigoid. two with linear IgA disease and two healthy subjects were studied either before starting treatment or after stopping dapsone for up to 5 days. Intradermal inoculation of freshly prepared autologous serum was followed after 18–24 h by the formation of DH‐like lesions in 24/31 DH patients. The lesions were erythematous papules, often with vesicles and microscopically showed papillary tip microabscesses. Serum‐induced formation of lesions only occurred in patients with active DH with some spontaneous lesion formation; it did not occur in any of the non‐DH controls. The formation of lesions was dose‐related, declining proportionately with dilution of the serum down to 1/16. Plasma prepared by various methods of anticoagulation (heparin. citrate. EDTA) caused lesser reactions, while addition of heparin or ε‐amino caproic acid (EACA), but not citrate, to serum substantially inhibited the formation of lesions. This suggested the responsible factor might be a protease. Other vasoactive agents including histamine (1–4 μg) and compound 48/80 (1–5 μg) caused normal immediate wealing. DH‐like lesions occurred in only one of 13 subjects challenged with histamine and two of nine challenged with 48/80. In all these, autologous serum elicited large vesicular responses. There is a factor(s) in serum in DH which can initiate the formation of lesions. This factor appears to be activated by clotting and can be inhibited by heparin and EACA, suggestin

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1991.tb03284.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

SummaryA 19‐year‐old veterinary nurse developed a cowpox/catpox virus (CPV) infection of her right third finger following a scratch from a tom cat suffering from pneumonia. The clinical course and investigation of the infection are described and the differential diagnosis discus

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1991.tb03285.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

SummaryThree males infected with the human immunodeficiency virus(HIV) were noted to have extensive flat warts of the face and/or body. In two there were also pityriasis versicolor‐like lesions. Biopsies showed foamy, basophilic, distended cytoplasm in granular layer keratinocytes, characteristic of the human papillomavirus types seen in epidermodysplasia verruciformis. DNA hybridzation techniques demonstrated the presence of HPV‐type 8 in one patient and HPV 5 and 8 in another. Patients with immune suppression due to HIV infection may demonstrate the clinical features of epidermodysplasia verruciformis with the same potentially oncogenic HPV ty

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1991.tb03286.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

SummaryA 22‐year‐old man presented with multiple raised erythematous skin lesions, pyrexia and epistaxis. A diagnosis of common acute lymphoblastic leukaemia (C‐ALL) was made by morphological, cytochemical, immunological and cytogenetic examination of peripheral blood and bone marrow. Biopsy of the skin revealed leukaemic infiltration by similar

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1991.tb03287.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

SummaryA patient is described who developed unilateral naevoid telangiectasia following metastases from a carcinoid tumour of the stomach.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1991.tb03288.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1991.tb03289.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

SummaryWe report a case of a 35‐year‐old female with a persistent pruritic acantholytic and dyskeratotic eruption on the chest and vulva. The light and electron microscopic studies showed suprabasal epidermal clefting with acantholysis and dyskeratotic cells. We suggest that the most appropriate term for this case is that of benign persistent papular acantholytic and dyskeratotic erupt

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1991.tb03290.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

SummaryFour cases of dermal melanocytosis with symmetrical areas of hyperpigmentation involving the face and extremities are reported. Light and electron microscopic studies showed changes similar to those seen in naevus of Ota.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1991.tb03291.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

This report is based on a 2‐day meeting held in Cambridge in January 1990. It picks out some of the recent advances since a previous meeging in 1984

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1991.tb03292.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY