摘要:

SummaryContact allergy to nail varnish is well‐known, and tuluenesulphonamide formaldehyde resin (TSAfr) was identified as the main allergen in 1943. During the period October 1989‐December 1991 we identified 18 cases of contact allergy to nail varnish. The aim of the study was to describe the clinical picture, patch‐test results, course and socio‐medical consequences. Seventeen of the 18 patients were patch‐test positive to TSAfr and 17/18 were positive to their own nail varnishes. Fourteen of the 18 were also positive to one or more substances in the standard patch‐test series. The lesions were scattered, involving the face, eyelids, neck and hands. Periungual lesions were recorded in 11/18. The dermatitis resolved within a few weeks when the use of nail varnish was stopped. The socio‐medical consequences of contact allergy to nail varnish bad heen severe: sick leave (nine cases), hospitalization (four cases), cessation of visual‐display‐unit (VDU) work (two cases), and job‐loss (two cases). Our conclusions are that contact allergy to nail varnish and TSAfr is common: the socio‐medical consequences may be severe: periungual lesions occur more frequently tban previously stated, and the presence of other contact allergies makes the diagnosis easy to miss. TSAfr should be included in the standard patch‐test series and patients should also be tested with their own nail varnishes. The study illustrates the need for mandatory declaration of the ingredients of cosmetics, as i

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1993.tb00148.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

SummaryThe medical records of 306 British soldiers in whom a clinical diagnosis of cutaneous leishmaniasis had been made following a tour of duty in Belize were analysed. Parasitological confirmation of the diagnosis was established in 187 cases: leishmania were cultured in 117 cases and Leishman‐Donovan bodies were identified histologically in a further 70 cases.Leishmania braziliensis braziliensiswas identified in 78 cases andLeishmania mexicana mexicanain a further 29 cases. Seventy‐one per cent of patients had a single lesion which, in most cases, occurred on the exposed extremities. The mean diameter of the ulcers was 14.4 mm. Treatment with sodium stibogluconate was effective. Two regimens were used, consisting of either 600‐800 mg daily given initially for 10 days, or 600 mg b.d. given initially for 14 days. Of those allocated to the lower dose regimen 48.5% were cured after the initial 10‐day course, and ultimately the ulcers of 93% of patients healed following more prolonged treatmentat this dose. Of those allocated to the higher dose regimen 63.9% were cured after the initial 14‐day course and ultimately the ulcers of all patients healed after more prolonged treatment at this dose. A transient leucopenia and a rise in liver enzymes were noted during treatment, and these changes were dose‐dependent. No cases of mucocutaneous leishmaniasis were

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1993.tb00149.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

SummaryThe ability to assess the severity of dermatoses by measurement of area of involvement is important in both clinical practice and research. Using schematic figure outlines we have shown that physicians, nurses and other groups are unable to assess area accurately, and that the degree of error is partially dependent on absolute area, but also on other factors. The pattern and magnitude of the errors varied between the groups examined, but overall was such that it calls in question the use of area indices such as the PASI (psoriasis area and severity index) score in the assessment of inflammatory dermatoses.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1993.tb00150.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

SummaryUV‐sensitive products which undergo a colour change on exposure to UV radiation are available for use by the general public. We have evaluated SunCheck® patches of various sensitivities, and Tanscan® UV sensor cards, in terms of their temperature stability, wavelength response and response to sunlight. The products exhibited no perceptible colour change when the temperature was maintained at 45°C for 4 hours; on exposure to monochromatic radiation, the sensitivity peaked at a wavelength of 335 and 355 nm for SunCheck® and Tanscan®, respectively; the response to sunlight under clear conditions was reasonably consistent, with the coefficient of variation for each type of material ranging between 12.5 and 27%. These products are based on the incorrect concept that there is a ‘safe’ dose of UV radiation. Thus, they cannot be recommended to the public as a reliable way of reducing the risk of s

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1993.tb00151.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

SummaryTwo cases ofthe Dowling‐Meara type of epidermolysis bullosa simplex (EBS) are described. Both had severe blistering at birth, which improved gradually with age. Vesicles and small bullae clustering in a herpetiform fashion were seen in both cases. One showed mild pincer deformity of the nails. and in the other the nail plates were shed after subungual blistering, but regrew without deformity, Histopathology and ultrastructural study showed cytolysis of the basal cells in both cases, but ultrastructurally different forms of tonofilament clumps were present in epidermal keratinocytes. In one case there was typical round clumping of tonofilaments, and in the other a whisk‐type clumping of tonofilaments. Cultured keratinocytes from the former produced round clumps of keratin filaments, but those from the latter did not. Review of previous reports of Dowling‐Meara EBS revealed that cases could also be divided into two groups in terms of the type of tonofilament clumping at an ultrastructural level. The possibility of subtyping of Dowling‐Meara EBS, and possible mechanisms of the blistering in this disease are di

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1993.tb00152.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

SummaryWe report three patients with the atypical mole syndrome (AMS) [also known as dysplastic naevus or FAMMM syndrome] who presented with primary acquired melanosis (PAM). PAM is a melanocytic lesion of the conjunctiva which may progress to conjunctival melanoma. The association of this rare condition with the AMS phenotype in three individuals suggests that PAM may he a conjunctival manifestation of the AMS.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1993.tb00153.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

SummaryWe report a 48‐year‐old Japanese man suffering from xeroderma pigmentosum associated with mental retardation, cerebral atrophy and cerebellar ataxia. Cultured fibroblasts from an unexposed area of skin had reduced DNA repair capacity after UV irradiation, with higher sensitivity to UV than normal cells in colony‐forming ability and host cell reactivation using herpes simplex virus. Genetic complementation tests by cell fusion with polyethylene glycol revealed that the patient belonged to group F. He died of bile duct cancer at the age of 50. This is the first report of an XP‐F patient with neurological abnorm

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1993.tb00154.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

SummaryWe report the case of a 67‐year‐old man who developed a pustular eruption, fever, neutrophilia and eosinophilia, following a short course of allopurinol. Toxic pustuloderma is an uncommon form of generalized pustular eruption with several characteristic clinical and pathological features. A number of drugs have been incriminated, but to our knowledge this is the lirst reported case of toxic pustuloderma occurring after the administration of allopuri

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1993.tb00155.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

SummarySolitary morphoea profunda is a recently described morphological variant of localized scleroderma. Two of the five reported patients had a solitary fibrotic plaque in the paraspinal region. We report a 16‐year‐old boy with a solitary fibrotic paraspinai plaque which, on histological examination, showed dermal and subcutaneous sclerosis, with a polymorphous infiltrate including plasma cells and eosinophils. Laboratory tests were either negative or normal, except for mild peripheral blood eosinophilia. Antinuclear antibodies were not detected, and the patient had no evidence of Borrelia infection. Magnetic resonance imaging (MRI) showed that the process involved the subcutaneous tissue, but did not extend to the underlying bone.As half of the patients with this entity (three of six) now described have had a solitary fibrotic plaque in a paraspinal location. we suggest that it may be premature to classify all these cases as being a variant of morphoea. We propose the use ofthe descriptive term solitary fibrosing paraspinal plaque, until the aetiology or aetiologies of this condition are better underst

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1993.tb00156.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1993.tb00157.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY