ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb07986.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.–Recent work on steroid metabolism in skin is discussed and it is shown that many metabolic transformations involve the 3β− and 17β−hydroxysteroid dehydrogenases. Histochemical techniques which are used are outlined, and the distribution of the 3β− and 17β−HSD within human sebaceous glands is described. The interesting patchy distribution of 17β‐HSD is described and an hypothesis concerning the pathogenesis of acne vulgaris is tentatively put forward. The basis for the use of antiandrogens in human skin is discussed and the definition of an antiandrogen using the histochemical screening method outlined. For the purpose of this paper the term antiandrogen is restricted to substances which directly inhibit certain enzymes of androgen metabolism in a histochemical system at the level of the sebaceous glands. A histochemical method for the screening of antiandrogens using human skin is described and the results with a few compounds reported and compared with the results of bioassay. The advantages and disadvantages of the technique are described and it is emphasized that the method is not intended to be used on its own, but simply as a scr

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb08002.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.—An optical technique for the assay of enolase in skin extracts is described. This has been used to confirm the presence of the enzyme in mouse and human skin. Certain properties of the skin enzyme were examined; in its solubility, its pH activity profile, and the degree of inhibition by fluoride in the presence and absence of orthophosphate it was very similar to enolase preparations from yeast and other tissue

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb02189.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.—A young woman developed widespread vascular spiders 9 months prior to admission. She was not pregnant and all tests of liver function were normal. A chronic hepatitis, possibly auto‐immune in origin, was diagnosed after a liver biopsy, and the hepatitis and the spiders cleared up after corticosteroid therapy.It is suggested that spiders may form in the blushing areas due to a loss of sphincter tone caused by impaired contractile cells in cutaneous arteriovenous shu

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb02190.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

THE development and secretory activity of the human sebaceous glands are dependent upon stimulation by androgens (Hamilton, 1941; Rony and Zakon, 1943; Strauss et al., 1962). Thus, measurements of sebaceous gland secretion have potential value in determining androgenic responses. This report will discuss utilization of the sebaceous glands in man for assaying androgens, as well as review information available to date on the effect of anti‐androgenic compounds on the human sebaceous glan

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb08003.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.—The pedigree of a family affected by Blue Rubber Bleb Naevi is described. In this family only males were affected. One affected male died with idiopathic pulmonary hypertension. A possible association between these conditions is postulate

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb02191.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.—A distinctive pattern of facial pigmentation is described. It is produced by repeated pressure on the skin in patients who indulge in “cheekbiti

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb02192.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.—Eosinophilia in guinea‐pigs and mice is mediated by antibodies that sensitize tissues anaphylactically. In the guinea‐pig these are guinea‐pig γ1 globulin antibodies and rabbit passive sensitizing antibodies; in the mouse, mouse γ1 globulin and reagin. The γ2 globulin antibodies in both species, mediate Arthus reactions without eosinophilia. However,in vitro, there is no difference between eosinophils and neutrophils in their response to antigen‐antibody complexes containing either γ2 or γ1 globulin, which are ingested by both types of cell.Eosinophils in anaphylactic or parasitized tissues are particularly attracted to large, basophilic mononuclear cells which are found in mesenteric milk spots, around parasitic granulomata and probably in lymph nodes.Histamine fails to evoke eosinophilia in guinea‐pigs and rats, though it traps eosinophils in the tissues, forming an apparent eosinophilia. Anti‐histamine drugs fail to suppress the eosinophilia of anaphylaxis in guinea‐pigs.Though generalized or local anaphylaxis results in eosinophilia, it is not known whether complexes of antigen with tissue passive sensitizing antibody on the cell surface attract the eosinophils, or whether they are attracted by some vascular permeability factor released from th

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb02193.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb08004.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.–An attempt has been made to show the possible importance of the fibrinolytic system in dermatology. The complex mechanisms of the system have been briefly explained and emphasis has been laid on the interrelationship between the fibrinolysis, coagulation, vaso‐active polypeptide and complement systems. The various methods for the study of fibrinolytic activity in the blood and in tissues are explained and their interpretation critically evaluated. The pitfalls in the study of blood fibrinolysis are emphasized. The fibrinolytic activity in normal human skin is located around the blood vessels and such activity in the epidermis has not been convincingly demonstrated. Damage to the skinin vivoby stripping with Scotch Tape appears to inhibit fibrinolysis. Homogenates of epidermis can be shown to contain an inhibitor of fibrinoly

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb07988.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY