摘要:

SUMMARYA new method for studying epidermalizationin vitrois described. It consists of inserting a punch biopsy that serves as a source of epidermis into dermal equivalent freshly made up, with fibroblasts mixed in a collagen matrix. Fibroblasts cling to collagen fibrils and contract the matrix, leading in 3 days to a resistant dermal equivalent holding the punch biopsy firmly in place. At day 5, a culture medium favouring epidermal growth was used and a fringe of a new epidermis appeared around the punch, the area of which grew linearly with time. This new epidermis showed a pattern of differentiation similar to epidermisin vivo, with cuboidal basal cells, keratohyalin granules, membrane coating granules and the expression of the 65–67 kd keratin subset.The method seems to combine the advantages of the explant technique and of classical keratinocyte cultures, providing the researcher with a large quantity of differentiated epidermis, the pharmacologist with simple and quantitative system in which to study modifications of growth and differentiation of epidermis, and the plastic surgeon with a possible material for skin graftin

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb02783.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SUMMARYA reflectance instrument was used to measure objectively the erythemal response to UV‐B and UV‐C radiation in subjects with polymorphic light eruption. The characteristics of the dose‐response curves obtained for each quality of ultraviolet radiation were significantly different, but were essentially indistinguishable from the comparable dose‐response curves measured previously in normal subjects. It is concluded that in this photodermatosis the chromophore(s) and mediator(s) of delayed (24 h) ultraviolet‐induced erythema are identical to those in no

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb02784.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SUMMARYTreatment with etretinate in a patient with multiple keratoacanthoma is described. Clinical improvement correlated with normalization of IL‐2‐production and mitogen induced lymphocyte proliferation. A causal relationship between reduced IL‐2‐production and eruption of keratoacanthoma is su

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb02785.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SUMMARYFifty‐three patients with atopic eczema took part in a double blind controlled cross‐over trial of an egg and cow's milk exclusion diet. Response to the diet was assessed in terms of areas affected, day and night time itch, and topical steroid usage.Twenty‐five percent of the patients failed to comply adequately with the trial regime and were excluded from the analysis. Of the remaining 40 patients, ten appeared to benefit from the diet and were advised to continue egg and milk avoidance. This response rate to the diet was not statistically signif

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb02786.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SUMMARYA patient with pyoderma gangrenosum, subcorneal pustular dermatosis and IgA paraproteinaemia is described.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb02787.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb02788.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb02789.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb02790.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb02791.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY