摘要:

SUMMARYAlthough psoralen photochemotherapy (PUVA) is one of the most effective forms of therapy for psoriasis, the risk of potential long‐term side‐effects is, as yet, not clearly determined. Chronic degenerative and pigmentary skin changes similar to those of chronic solar exposure occur after long‐term PUVA treatment; PUVA also causes non‐melanoma skin cancers in man, although there is, as yet, no consensus as to what cumulative phototoxic PUVA dose is carcinogenic. Long‐term multicentre studies from the U.S.A. indicate a definite risk of squamous cell carcinoma for long‐term PUVA‐treated patients, whereas European studies reveal no overall increase in skin cancers in similar patients except for those exposed to other carcinogens. Assignment to PUVA should be based on the risk:benefit ratio for the individual patient. Careful patient selection is therefore mandatory and should be limited to those who can be monitored and controlled by informed, competent and conscientious physicians.Psoralen photochemotherapy (PUVA)’is one of the most effective forms of therapy for psoriasis2. It induces a complete clinical remission within a reasonably short period of time and, as maintenance therapy, can produce a remission for an extended period. In combination with retinoids,3the clinical efficacy of PUVA is greatly improved and is likely to minimize the potential long‐term side‐effects.There is now considerable clinical experience regarding the short‐term safety of PUVA, but the risk of potential long‐term side‐effects is, as ye

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb02889.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb08253.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb08254.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb16137.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Book reviewed in this article:Oxford Handbook of Clinical Specialities.J.A.B.Collier andJ.M.Longmore(1989).A Colour Atlas of AIDS in the Tropics. M.A.Ansary, S.K.Hira, C.Chintu andS.L.Nyaywa(1989).

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb08256.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb08257.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

SUMMARYMethotrexate is by far the most widely used cytotoxic drug in psoriasis. Treatment requires normal kidney, liver and bone‐marrow function, and pregnancy and alcohol abuse are absolute contraindications. Serious toxic reactions are recognized, but can be avoided if the drug is used correctly. The most important side‐effects are haematopoietic and hepatotoxic. It is well established that long‐term methotrexate can induce liver damage which, in a number of patients, may lead to fibrosis or cirrhosis. Recent studies have, however, documented that the methotrexate‐induced liver cirrhosis is not aggressive. Interaction can occur with a number of drugs; serious problems in particular may arise with concomitant use of sulphonamides and salicylates. The recommended guidelines for methotrexate use in psoriasis should be followed and patients given clear instr

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb02890.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

SUMMARYThis is a review of the efficacy of etretinate/acitretin in the treatment of psoriasis and of the currently reported side‐effects. The data indicate that retinoids bring significant improvement (if not total clearing) with frequent low‐morbidity but rarely serious side‐effects. The most serious side‐effect of etretinate/acitretin is teratog

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb02891.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb02874.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY