摘要:

SummaryBacillary angiomatosis is a recently recognized bacterial infectious disease that is seen mainly in patients with the acquired immunodeficiency syndrome. Including this publication, 45 patients have been described in the medical literature. In this report we describe examples of the clinical presentations of bacillary angiomatosis and review therapeutic strategies.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1992.tb00096.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

SummaryIn an attempt to find an effective therapy for necrobiosis lipoidica, we have treated six patients with this disease with a 5‐week course of systemic corticosteroids. This treatment resulted in complete cessation of disease activity in all patients and no recurrence in a mean follow‐up period of 7 months; however, restitution of atrophic skin lesions could not be achieved. The therapy was well tolerated and did not pose problems, even in diabetic patients. These results strongly suggest that short‐course therapy of necrobiosis lipoidica with corticosteroids is of lasting benefit to these patients and should probably be considered early in the course of their skin di

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1992.tb00097.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

SummaryAntinuclear antibodies are useful markers of connective tissue disease. In this study, UVB but not UVA induced the expression of Ro/SSA antigen on keratinocyte surfacesin vitro. This expression was also found with the extractable nuclear antigens RnP and Sm, but not with single or double‐stranded DNA. The expression was prevented by blocking protein synthesis, suggesting that it was an active process. The results suggest that UVB exposure may result in the expression of Ro/SSA antigen on the surfaces of basal keratinocytesin vivo. This antigen could then bind circulating antibody leading to the cutaneous lesions in neonatal and subacute cutaneous lupus erythematosu

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1992.tb00098.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

SummaryUltraviolet B light (UVB) has previously been shown to induce the expression of the extractable nuclear antigens (e.g. Ro/SSA) on the surfaces of human keratinocytesin vitro. This study assessed whether injurious, metabolic, inflammatory, immunological or hormonal stimuli would also induce this expression or modulate that produced by UVB. No stimulus initiated expression alone, but 17‐βoestradiol doubled that found in response to UVB. These findings confirm the potential role of UVB in the initiation and potentiation of cutaneous lupus lesions and may help to explain the female preponderance of the disea

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1992.tb00099.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

SummaryVarious parameters for assessing endothelial cell (EC) metabolism, including immunohistochemistry and adenosine uptake, have been compared in the clinically uninvolved skin of patients with diffuse systemic sclerosis (DSS), CREST, incomplete CREST syndrome (ICREST), primary Raynaud's disease (1° RD) and normal controls. Evidence of platelet adhesion to EC, decreased EC storage of factor VIII‐related antigen, changes in EC morphology and decreased adenosine uptake by EC, were found in the dermal microvasculature of normal skin of patients with DSS, CREST and ICREST, but not in 1° RD. These data indicate that a generalized microvascular endothelial dysfunction is present in the skin of patients with the systemic forms of sclerode

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1992.tb00100.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

SummaryIt has been suggested that there is a widespread abnormality of the capillaries in the skin of patients with psoriasis. This study was carried out to obtain more evidence on this point. Lesions of 20 patients with typical psoriasis, and uninvolved skin 3 cm from these lesions, were biopsied and compared with biopsies from 10 normal healthy control subjects. The dermal microvasculature was quantified in all these biopsies with regard to endothelial and luminal volume relative to the volume of dermal components of skin using stereological point counting methods utilizing the Delesse principle.The values for endothelial volume in specimens taken from the centre of the lesions did not differ significantly from those taken from the margins (33.6 × 10−3and 35.8 × 10−3, respectively). The same was true for the luminal volume from the two sites (9.1 × 10−3and 10.0 × 10−3, respectively). There was a highly significant difference, however, between the value for endothelial volume in biopsies from psoriatic patients compared to controls (P<0.001) and specimens from uninvolved psoriatic skin also showed a highly significant difference (P<0.001) from involved areas. There was no significant difference between uninvolved areas in psoriasis patients and control specimens. Significant differences were also found between values for control subjects and those for both involved and uninvolved psoriatic skin for luminal volume (P<0.001). The number of capillary profiles counted in each group produced a similar rank ordering to the other parameters examined, i.e. psoriasis psoriatic uninvolved normal.It was concluded that vascular mass and vessel dilatation was greatly increased in psoriatic lesions and to a lesser extent in the uninvolved skin of psoriatic patients, and it is believed that this helps confirm that the abnormality to the microvasculature in the skin of patients with psoriasis is not confined to

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1992.tb00101.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

SummaryThe expression ofUlex europaeusagglutinin (UEA I) binding siteson cell‐surface glycoproteins has been used as a marker for terminaldifferentiation. Increased number of UEA I binding sites ofl‐fucose specificity have beendemonstrated in psoriatic epidermis. The results of lectin‐bindingstudies in a series of biopsies taken sequentially (0 min, 5min, 24h, 7 days and 8 weeks) after tape‐stripping of uninvolved skin in 12psoriatic patients (three of whom were taking diltiazem, a calciumblocker at the time of the study) and six controls are presented. UEAI binding sites, which were expressed on the granular layer and upperlayers of the stratum spinosum of pre‐tape stripped uninvolved skinin psoriatic individuals, were progressively more numerous, with theexpression of thel‐fucose moiety onthe lower stratum spinosum keratinocytes in the 7‐daypost‐tape‐stripping biopsies and 8‐week biopsies, correlating with amoderate and marked increase in the proliferative index, respectively. In the Koebner‐negative and non‐psoriatic individualswho failed to develop psoriasis after tape‐stripping, the UEA Ibinding sites were not expressed on keratinocytes of the lowerstratum spinosum in any of the biopsies, although a mild increase inthe proliferative index was noted in the 7‐day biopsies. Our datasuggest that the increased commitment of keratinocytes to terminallydifferentiate may be involved in the psoriatic process. There is someevidence that the signal initiating a series of events leading toterminal differentiation may be the influx of extracellularCa2+into the keratinocyte cytosol. The failure of ourpsoriatic patients on diltiazem to develop psoriasis may prov

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1992.tb00102.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

SummaryThe presence of pericapillary fibrin and complement C3c in the ulcers of 19 patients with venous hypertension and 14 patients with ischaemic leg ulcers was investigated using histochemical and immunohistochemical techniques. There was deposition of fibrin around the capillaries in the central part of the ischaemic ulcers, and the venous hypertension ulcers, and in the non‐ulcerated skin around one of the venous hypertension ulcers and two of the ischaemic leg ulcers. The deposition of fibrin is a secondary phenomenon that occurs in the area of ulcerated skin and dose not play a major causal role in the formation of chronic leg ulcer

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1992.tb00103.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

SummaryAntibiotic resistance of the resident cutaneous bacterial flora is a well recognized consequence of systemic antibiotic therapy. In this study, we followed the development of antibiotic resistance of coagulase‐negative staphylococci (CNS), the most numerous aerobic bacteria found on the skin surface, during treatment with three topical antimicrobial agents used to treat acne vulgaris. Groups of 20 subjects received either topical erythromycin, benzoyl peroxide or a combination of the two for 16 weeks. After 12 weeks of treatment with erythromycin, the aerobic flora was dominated byS. epidermidiswhich was completely resistant to erythromycin. In addition there was an increase in resistance to clindamycin and tetracycline. Treatment with benzoyl peroxide and the combination of erythromycin and benzoyl peroxide resulted in a significant reduction in the number of aerobic bacteria without any change in the resistance pattern to erythromycin or other antibiotic

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1992.tb00104.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

SummaryThe fusidic acid steady‐state concentrations in serum (S) and skin suction blister fluid (SBF) after oral doses of 250 and 500 mg administered twice daily for 6 days, as film‐coated tablets of sodium fusidate, were studied in eight healthy subjects. The mean peak serum concentrations after the 250‐ and 500‐ mg regimens were 39 ± 5 and 102 ± 11 mg/l, respectively, obtained between 2 and 3 h after drug intake. The corresponding values for SBF, obtained later, between 2 and 12 h after drug intake, were 21 ± 5 and 79 ± 11 mg/l. As measured by the ratio of area under the concentration vs. time curve (SBF/S), fusidic acid penetration is 69–75%, whatever the dose. With either regime, the fusidic acid SBF and serum levels exceed the minimal inhibitory concentration of bacteria usually found in skin infections, especiallyStaphylococcusspecies. A dose of 250 mg twice a day appears sufficient to treat these infections and could be tested in cli

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1992.tb00105.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY