摘要:

Summary.—Data concerning 155 patients with all types of generalized pustular psoriasis have been reviewed. Generalized pustular psoriasis of Yon Zumbusch type is a severe disease. Thirty‐four of 106 patients followed up have died. In 26 of these, death was attributable to the disease or its treatment. G.P.P. developing from acral pustulosis (acrodermatitis continua) has the worst prognosis and is likely to prove fatal. G.P.P. evolving from ordinary, pustular palmo‐plantar or atypical fiexural forms of psoriasis has a better prognosis and may remit spontaneously.The use of steroids systemically for ordinary or erythrodermic psoriasis may precipitate G.P.P. and perpetuate the severe phase of psoriasis. Methotrexate is advocated for the treatment of the severe acute phase; but, in some patients, systemic steroid therapy cannot be av

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1971.tb14044.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Summary.—The incidence ofPseudomonas aeruginosain lesions and faces of patients with diseases of the skin has been investigated for a period of 10 months. Of 308 patients, 18%, were found to carryPs. aeruginosaon admission. Forty‐five patients had lesions infected withPs. aeruginosa, 26 of these being faecal carriers, but only 7 carried the same strain in both sites. The possible significance of environmental contamination is discus

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1971.tb14045.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Summary.—A hypopigmented lesion is described, which on initial inspection appears to be macular, but on closer examination and palpation is appreciated to be slightly elevated. It is oval or round in shape with a cauliflower‐like, scalloped border and cobblestone surface. Histopathologically it appears to be a variant of seborrhoeic kerato

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1971.tb14046.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Summary.—Quantitative chemical analysis for hyaluronic acid (HA) and derMatan sulphate (DS) was performed on biopsies from 9 healthy volunteers and from the lesions of 30 patients with skin disease. The following observations were made:(1) Values for both HA and DS in the skin of healthy volunteers were higher than those reported previously for post‐mortem material.(2) A striking decrease was found in the HA, together with a less marked reduction in the DS level, in lesions of discoid L.E. and scleroderma.(3) A very low DS level was found in a single case of dystrophic epidermolysis bull

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1971.tb14047.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Summary.—Followingin vitroculture of 4 mm discs of human skin in the presence of14C‐acetate, the intact sebaceous glands have been harvested, using 1 mol/1 calcium chloride, thus permitting a study of the incorporation of14C into the sebaceous gland lipids and into the lipids of the overlying appendage‐freed epidermis. The method is reliable, and satisfactory patterns of incorporation have been obtained from sebaceous glands harvested from single biopsies (5–15 glands).The pattern of incorporation obtained from the sebaceous glands has been contrasted with that from the appendage‐freed epidermis, and compared with previously reported biochemical analyses of the lipids of the isolated sebaceous gland and surface film.It is suggested that this technique could be applied to the study of sebaceous gland lipogenesis in a variety of clinical conditions and used as anin vitroscreening procedure for drugs likely to influence sebum

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1971.tb14048.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Summary.—When applied to guinea‐pig skin, alicyclic hydrocarbons cause morphological changes and alter the epidermal arginase activity. The magnitude of the effect is relative to the molecular weight of the hydrocarbon applied, and the relationship of the morphological changes to the change in arginase activity is the reverse of that reported for linear hydrocarb

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1971.tb14049.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Summary.—The structure of callus differs in many respects from that of normal human stratum corneum. This finding was confirmed both by scanning and transmission electron microscopy. Callous material consists of 2 types of horny cell as does normal stratum corneum. Both types, however, are thicker (5– 8 μm) and extremely interdigitated as compared with normal horny cells. All intercellular spaces in callus are occupied by a dense cement material; signs of desquamation are therefore absent. After treatment with acid sodium thioglycolate (aNaThG) the dense matrix of callus keratin is reduced, the keratin framework of the horny cells is loosened and the characteristic α‐keratin pattern can be observed. Moreover, most of the intercellular cement material is dissolved and some of the desmosomes are degraded. After aNaThG treatment and prolonged fixation in osmium, only the horny cell borders and a fibrillar skeleton remain.According to our findings, callus keratin is constructed similarly to the keratin of finger pad epidermis and of nail. The mode of keratinization in callus resembles that of hyperkeratosis by proliferation and not parakeratosis. Compared to nail keratin and the keratins of hair, however, callus keratin is less resistant to aNaThG. The high aNaThG‐resistance of the horny cell border points to its function as a solid, stable container for

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1971.tb14050.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Summary.—Sodium fusidate ointment has been used in the treatment of erythrasma in a mental hospital. In comparison with a benzoic acid (Whitfield's) ointment it proved as effective in clearing fluorescent lesions (90%‚cure’) and more effective in clearing the associated Corynebacterium minutissimum. It was, however, less effective in removing sc

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1971.tb14051.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Summary.—Oral trimethylpsoralen was given to 12 children with different clinical types of vitiligo in a dosage of 5–10 mg daily, followed by exposure to sunlight. The response to this therapy was favourable. Vitiligo areata responded the best as compared to the other types. No cutaneous or systemic side effects were seen. Trimethylpsoralen is therefore recommended for the treatment of vitiligo in child

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1971.tb14052.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Summary.—The penetration of fluocinonide from solution in DMSO across human abdominal skinin vitrohas been examined. Different volumes of solution, ranging from 0.025 ml to 0.75 ml, were studied.The results show that better penetration is achieved in thisin vitrosituation from smaller volumes than from larger volumes. Possible mechanisms that might account for this phenomenon are discussed. A possible explanation considers that the flux of water into the DMSO solution causes an increase in the thermodynamic activity of the drug and hence in the penetration rate of the drug into and through the ski

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1971.tb14053.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY