ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15693.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARYImmunofluorescence studies were made in 51 cases of rosacea and 8 cases of telangiectasia of various origins. Immunoglobulins were found—as in LE—at the epidermal‐dermal junction in 35 of the cases of rosacea and in all telangiectasias, irrespective of their origin. The need for great caution in the interpretation of biopsy studies of facial lesions is stressed. Detection of immunoglobulins at the epidermal‐dermal junction in clinically normal skin is, however, very important for the diagnosi

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15694.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARYAn account of the histogenesis, histopathology, histochemistry and clinical features of the clear‐cell acanthoma is based on the authors’ extensive personal experience and a complete review of the world literat

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15695.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARYWe are reporting an original observation in a patient with sarcoidosis with typical lesions on the face and in the right axilla together with characteristic changes in the lymph nodes. The interest of this observation arises from the presence of certain atypical clinical and pathological features. Clinically there were on the legs macular atrophic lesions and ulcers showing all the characteristics of ulceration due to arteriolitis. Histopathologically the lesions on the legs showed marked hyaline degeneration which appeared to play an important role in the development of the atrophic macules and ulcers. In addition orceinophilic fibres were present in the middle of some of the sarcoid granulomata on the face.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15696.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARYThree cases of vascular calcification, cutaneous gangrene and hyperparathyroidism are presented. Biopsy of the skin reveals calcinosis of the media as well as obstruction of a muscular vessel. Secondary, as well as primary, hyperparathyroidism is associated with this characteristic cutaneous syndrome. Treatment of the parathyroid disease and conservative skin therapy will produce reversal of vascular calcification and healing of the skin.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15697.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SummaryFour patients with a similar eruption of distinct livid plaques are presented. Clinically, the lesions were difficult to diagnose as either lichen planus or lupus erythematosus. However, histological studies with standard and immunofluorescence staining methods were more consistent with lichen planus. In contrast, certain laboratory findings and the clinical course were suggestive of lupus erythematosus.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15698.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARYAn experimental study using free skin grafts was carried out in a human volunteer in order to study the absorption and formation of amyloid in primary amyloidosis of the skin.Normal full thickness grafts from the medial aspect of the upper arm were transplanted to an affected area on the extensor surface of the leg andvice versa.The experiment was followed up for 13×12 years. Twenty‐one biopsies were performed during the years 1956 to 1969. Biopsies from the grafted areas on the leg and upper arm were taken in 1956, 1959, 1961, 1963, 1964 and 1969.The biopsy specimens demonstrated the slow disappearance of amyloid positive material in the grafted area of the upper arm. The specimen still contained positive material in 1959. In 1961 the metachromatically stained material became less compact and consisted of small dot‐like areas. These became smaller in 1963 and 1964 and disappeared almost completely in 1969. Only occasional metachromatically stained dots could still be found in the subpapillary area. The reverse process occurred in the grafted area on the right leg. The skin of the upper arm was negative for amyloid in 1956 and in 1959. The methyl violet stain became positive in 1961 and remained positive In all following biopsy specimens up to

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15699.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SummaryAttention is directed to the clinical recognition of early proliferative change in the lining of keratinous cysts. In the case reported, multiple small droplet excrescences could be observed on simple inspection. The term hydatidiform keratinous cyst is proposed as a designation for this distinctive clinical variant. Histologically it is to be distinguished from squamous cell epithelioma. It possibly represents an early clinically identifiable phase of the proliferative epidermoid cysts described by Wilson Jones (1966).

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15700.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SummaryWhen ultrathin sections of normal epidermis were stained with uranyl acetate, but especially when the tissue blocks in addition were prestained with uranyl acetate while being dehydrated, each keratinocyte showed a densely stained continuous layer peripheral to the light mid‐layer of the trilaminar plasma membrane. Within desmosomes this dense layer was quite regular in thickness and corresponded to the intermediate dense layer, as described by Odland (1958). Outside of desmosomes, however, the dense layer was very irregular in thickness, indicating that this layer was not identical with the outer leaflet of the plasma membrane. In pemphigus acantholysis the dense layer within desmosomes was largely dissolved and thus the much thinner outer leaflet of the plasma membrane was revealed.It is concluded that the dense layer surrounding each keratinocyte, including the intermediate dense layer of Odland, is composed of the outer leaflet of the plasma membrane and a variable amount of intercellular substance condensed on it as a cell surface coa

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15701.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SummaryHistochemical localization of HSD activity was investigated in sebaceous glands in skin of rat, guinea‐pig, hamster and gerbil. Rat preputial gland, hamster costovertebral organ and gerbil ventral gland were also used. Rat skin and preputial gland showed HSD activity with DHA. oestradiol and 5‐androstene‐3β‐16β‐diol‐3 methyl ether substrates while testosterone was poorly utilized in the 17β‐HSD reaction.Guinea‐pig lip sebaceous glands showed HSD activity with DHA, oestradiol, testosterone and 5‐androstene‐3β‐16β‐diol‐3 methyl ether. None of the other tissues showed convincing HSD activity w

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15702.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY