摘要:

SUMMARY.—A wave of contact dermatitis due to an optical whitener in washing powders is occurring in Copenhagen. A report is given on 30 patients diagnosed in only 2 months.The clinical features are those of a textile dermatitis.The typical lesions are irregular, faintly red or red‐brown spots with a finely wrinkled or crackled surface; by confluence a reticulate pattern is formed.In many cases the changes are minimal and may easily be overlooked, but there is nearly always rather severe itch

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15947.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—Persistent angiomatous nodules and plaques about the ears and scalp with distinctive histological features are described. Of the 12 women and 2 men affected, 9 showed involvement of the external auditory meatus, the pinna or the retroauricular fold. Three patients presented with lesions in the occipital region and solitary nodules affecting the nasolabial fold and forehead occurred in 2 patients. Eight patients had multiple lesions with bleeding and pruritus as the main symptoms. Several recurred after removal.The characteristic histological features were the presence of abnormal hypertrophied capillaries with greatly swollen endothelial cells and an associated lympho‐histiocytic and eosinophil infiltrate. The abnormal endothelial cells showed absent or greatly diminished alkaline phosphatase activity, but enhanced reactions were obtained to certain hydrolytic and oxidative enzymes as compared to normal capillary endothelium.Pseudopyogenic granuloma appears to be an entirely benign reactive condition. Its relationship to ordinary pyogenic granuloma and to subcutaneous angiolymphoid hyperplasia with eosinophilia is discus

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15948.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—Malignant atrophic papulosis occurring in mother and son is described. Hitherto this condition has not been described in 2 members of the same family nor, to our knowledge, have there been previously reported cases from the U.K. Genetic and environmental factors involved in the pathogenesis of this disease are discusse

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15949.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—Pasteurella pseudotuberculosisis a widely distributed coccobacillary infection of birds and animals. Infections in man may present as mesenteric adenitis, lymphadenopathy, upper respiratory infections or pharyngitis: a septicaemic form occurs.Erythema nodosum has been reported, particularly in France, as a complication of such infections in children and young adult females.In an epidemiological survey of erythema nodosum in one region of England, two cases of erythema nodosum were found in children in which evidence of infection byP. pseudotuberculosiswas obtained by agglutination and intradermal antigen tests.The diagnostic criteria are examined. A series of intradermal antigen tests and agglutination titres carried out on other patients with erythema nodosum and controls does not suggest that this infection is common in the area studied or is a frequent cause of erythema nodosum. But it is one that may easily be overlooke

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15950.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—The microscopic changes in geographic tongue (superficial migratory glossitis) include spongiform pustules similar to those which occur in acrodermatitis continua of Hallopeau, impetigo herpetiformis, pustular psoriasis and Reiter's syndrome. The presence of spongiform pustules in geographic tongue was first described by Gastou in 190

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15951.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—Phytohaemagglutinin (PHA)‐stimulated peripheral lymphocyte transformation was significantly inhibited in all cases of active sarcoidosis of the respiratory system.The inhibition affected even the earliest stages of transformation, as was shown by the markedly depressed percentage of first mRNA and the DNA‐synthesizing cells in cultures.The inhibition was independent of how far the disease had advanced (the phase of the disease) but was clearly correlated with its activity (stage). During remission the level of PHA‐stimulated transformation rose by a statistically significant

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15952.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—The histochemistry of benzpyrene‐induced malignant skin tumours has been studied. The metabolism of these cells appeared to involve suppression of the succinic dehydrogenase‐cytochrome oxidase system; enhanced activity for enzymes of the pentose cycle and increased reaction for enzymes associated with the glycolytic pathway. The inhibition of the “succinoxidase” system has been discussed in relation to the possibility of deletion of the enzyme system by the carcinogen. This might result in the release of the metabolism of these cells from the normal regulatory control of the cytochrome pathway thus producing an enhancement of the growth potential of th

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15953.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—A patient whose lesions satisfied the clinical and histological criteria for the diagnosis of confluent and reticulate papillomatosis (C.R.P.) is described. Many of the lesions showed yellow fluorescence and were heavily colonized byPityrosporum orbicularebut no evidence was found of filament formation as inMalassezia furfur.Treatment with 10% sodium thiosulphate and with selenium sulphide resulted in virtual eradication ofP. orbiculareand complete clearance of the eruption. The possibility is discussed that C.R.P. may represent a peculiar host reaction to heavy colonization byP. orbicular

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15954.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—Followingcompletecellophane tape stripping of the plaques in psoriasis, the sweat rates were significantly greater than the rates in stripped clinically normal skin between the plaques.Na+, K+, urea and lactate concentrations were all considerably reduced in sweat collected from the plaques before stripping. K+and urea concentrations increased after stripping but remained less than the concentrations in the sweat from the clinically normal skin. Lactate concentrations in sweat from the plaques remained low after stripping and the increase in Na+was less than anticipated from the change in sweat rate.These changes are interpreted as a primary defect in sweat duct function in the plaques involving impaired absorption of water and to a lesser extent Na+from the primary secretion produced by the coil. This results in an apparent increase in sweat rate and reduced solute concentrations after stripping.It is concluded that there are two major defects in the sweat glands in psoriasis, (i) sweat duct blockage, (ii) impaired ductal absorption, primarily of water, but also of Na+. There is also a defect in lactate metabolism in the sweat gland, the nature of which has not yet been define

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15955.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—Two patients are reported with ichthyosis linearis circumflexa as the cutaneous manifestation of a syndrome resembling Netherton's disease.There were multiple defects of the hair shaft, ranging from simple variation in calibre to trichorrhexis nodosa, bamboo hairs and cup and ball deformities of many types.The histological appearances of the follicles are described and the possible significance of an associated aminoaciduria is discusse

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15956.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY