摘要:

SUMMARYThe random and active migration of neutrophil leukocytes in agarose was studied in sixty‐one patients with psoriasis and in healthy controls.E. colifiltrate was used as chemoattractant. The random as well as the active migration was increased in psoriasis. The increase was most pronounced in those cases with widespread psoriasis. In twenty patients who were followed for 1–3 years, the neutrophil chemotactic activity remained essentially unchan

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb07256.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYA new instrument has been developed and used to determine the effect of various materials on nail flexibility. It repeatedly flexes longitudinal nail sections through 90 degrees and records the number of flexions required to fracture each section.Immersion in water or a phospholipid‐water preparation (PLW) greatly increases the flexibility of untreated and lipid extracted nails; immersion in mineral oil does not.Nail flexibility is directly related to the duration of their immersion in water. During water immersion, nail weight increases by 22% of its original weight within 2 h, and then decreases. The rapid increase in nail flexibility during water immersion is related to nail water content.It is possible to prolong the flexibility of previously hydrated nails by the application of PLW or mineral oil. PLW is more effective than water alone in prolonging flexibility of nails extracted with a mixture of acetone, water and acetic aci

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb07257.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYAn extract prepared from 200 adult female scabies mites was used for prick and intracutaneous testing in twelve patients with previous scabies infestation, as well as in six healthy controls and three persons with skin sensitivity toDermatophagoides pteronyssinuswho had never had scabies before. Seven individuals who had had scabies less than a year prior to the testing had positive intracutaneous (immediate type) reactions, whereas all the five who had had scabies more than a year before had negative reactions. The prick tests were negative in all cases. No skin reactions could be evoked in the controls. The passive transfer, or Prausnitz‐Küstner, test was positive with the scabies mite extract and serum from three of five patients tested on one healthy individual, and with both of two sera tested on a second healthy individual. These findings indicate that immediate type hypersensitivity reactions may occur with scabies infecti

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb07258.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYStreptococcus milleriwas isolated from the active lesions of three patients with perineal hidradenitis suppurativa. In each patient, elimination of this organism by appropriate antibiotic therapy was accompanied by marked clinical improvement.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb07259.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYBacteria were sampled using a ‘scrub’ technique from the skin surface of the faces of forty‐nine female subjects aged 18–21 years. The sebum excretion rate was determined by a gravimetric method and the level of free fatty acids by titration. The production rate of free fatty acids was calculated from the product of the concentration of free fatty acids in the sebum and the sebum excretion rate.The date were analysed using Kendall's rank correlation method. Positive correlations existed between the number ofMicrococcaceaeand the skin propionibacteria (P<0.001) and between both groups of organisms and the production rate of free fatty acids (P<0.001). There was no significant correlation between the size of the bacterial population and the sebum excretion rate. The results support the view that free fatty acids are produced as a result of bacterial action, that theMicrococcaceaeand skin propionibacteria do not compete to the detriment of their respective populations, and that the size of the bacterial population is not dependent upon the sebum excreti

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb07260.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYBy means of small waterproof chambers held on the backs of rats with adhesive, areas of skin were exposed continuously to sterile distilled water for 1‐, 2‐ and 3‐day periods. All test areas showed discernible changes and many exhibited vesicles, bullae or abscesses in the epidermis. Dermal changes ranged from mild inflammatory cell infiltration to severe oedema and haemorrhagic inflamm

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb07261.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYIn an adult human epidermal cell culture system in which three different types of dermo‐epidermal junctions could be observed, thein vitrosynthesis of basement membrane and type IV collagen was studied with electron microscopy and indirect immunofluorescence via an antiserum to type IV collagen. Essentially, keratinocytes juxtaposed to non‐living substrate did not produce either type IV collagen or an ultrastructural basement membrane, whereas both products were found at dermoepidermal junctions composed of living keratinocytes juxtaposed to living dermis. This suggests that the microenvironment of the keratinocyte may influence the synthesis of junctional compone

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb07262.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYNine patients with hereditary angio‐oedema (H. A. E.) with a deficiency of C1 esterase inhibitor (CI INH), have been treated with low dose attenuated androgenic drugs, with complete control of their disease. The CI esterase inhibitor and C4 levels became normal in only one patient. It is concluded that H. A. E. can be controlled in the absence of correction of the reduced levels of C1 INH and C4. The mode of action of these drugs appears to be more complex than is generally realize

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb07263.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYTwenty‐four patients suffering from psoriatic arthritis participated in a double blind cross‐over trial of peroral zinc sulphate versus placebo (Trial I). Eleven patients continued an open trial of peroral zinc sulphate for an additional 24 weeks (Trial II). Remission was assessed by the disappearance of symptoms (overall condition, morning stiffness, functional capacity of the joints and joint pains), and signs (mobility and swelling of the joints). Reduction of joint pains as well as increase of mobility and decrease of swelling of several joints were observed. The clinical signs of reduced inflammation were accompanied biochemically by reduction of serum immunoglobulins and an increase of serum albumin. The need for analgesics was diminished. Severe side‐effects and changes in the psoriatic skin involvement were not seen. Oral zinc sulphate seems to be valuable in the treatment of psoriatic arth

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb07264.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYSerum levels of 8‐methoxypsoralen were determined in six human volunteers after two different methods of oral administration.8‐Methoxypsoralen was given as an aqueous solution and as powder in gelatin capsules. The area under the curve (AUC) values were higher (P<0.05) for the solution than for the capsules, indicating a higher bioavailability. Also, the peak serum levels were higher and were reached earlier when given as a solution. Considerable individual variation of the maximum serum levels and the area under the curve values was observed for both methods of administration, but the time required to reach the maximum serum level was more predictable after administration of the solut

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb07265.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY