摘要:

SUMMARYFifty two psoriatic patients were treated with a new experimental fluorescent lamp (Philips TL‐01) emitting a narrow band at 311 ± 2 nm (UVB) which had the advantage of a reduction in burning and carcinogenic wavelengths when compared with conventional broad band UVB therapy. Results of the ‘311’ treated group when compared with broad band UVB therapy revealed a similar percentage of patients achieving a satisfactory response with fewer burning episodes and an increase in duration of rem

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb03489.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

SUMMARYUVB phototherapy of atopic dermatitis was investigated in two paired‐comparison studies. In study 1, 17 patients were treated for 8 weeks with ultraviolet B radiation (UVB) on one half of the body and with visible light (placebo) on the other. A severity score based on eight clinical variables was determined before, during and after treatment. The total score, pruritus score and overall evaluation score were significantly better on the UVB treated sides than on the placebo treated sides (P<0.001). In 13 patients the UVB treated side healed or improved considerably, while the placebo treated side improved considerably in one patient only.In study II, 25 patients were treated for 8 weeks with 0.8 of the minimal erythema dose (MED) of UVB on one half of the body and with 0.4 MED UVB on the other. No statistically significant differences between these dosage regimens were foun

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb03490.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

SUMMARYElevated levels of serum interleukin 2 receptor (IL2R) represent an early measure of T cell activation. The concentration of IL2R was measured in the sera of patients with atopic dermatitis (n= 58) or psoriasis, without psoriatic arthritis, (n= 26), who had moderate to severe disease activity, and in non‐atopic healthy controls (n= 37) by an ELISA technique. Serum IL2R levels were found to be significantly elevated in both disease groups compared with the controls. The increase in serum IL2R may be due to T cell activation in the dermi

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb03491.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

SUMMARYWe measured sister chromatid exchanges (SCEs) in lymphocytes of eight MF patients before, and 2 h, and 24 h after treatment with topical nitrogen mustard. The mean number of SCEs/cell (± SEM) were 8.15 (±0.62), 8.34 (+ 0.55) and 8.26 (±0.56), respectively. The 2 h and 24 h results do not differ significantly from pretreatment levels. Our results show that concentrations of nitrogen mustard used to control MF do not induce SCEs in peripheral blood lymphocyt

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb03492.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

SUMMARYUsing an immunoelectron microscopic technique we have compared the ulrastructural localization of IgG and complement (C3) in the basement membrane zone of three typical cases of bullous pemphigoid and three atypical variant cases (nodular, polymorphic and localized pemphigoid, respectively). There was no significant difference in thein vivoultrastructural localization of these immunoreactants between the typical and the atypical cases of pemphigoid. In all cases IgG and C3were detected between the basilar surface of the basal keratinocytes and the basal lamina. Moreover, thein vitrobinding sites of circulating anti‐basement membrane zone antibodies were identical in the case of nodular pemphigoid and a typical pemphigoid as control. We also observed that immunoreactants were not deposited beneath melanocyte

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb03493.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

SUMMARYAndrogenic stimulation of sebaceous glands is necessary for development of acne. If hyperandrogenaemia were a major determinant of acne in women, the frequency of other clinical markers of androgenicity should increase with acne severity. To investigate this, 268 female subjects (aged 12–44 years) were studied. Subjects were divided into groups on the basis of acne severity: physiological, moderate, and severe. With exclusion of women taking oral contraceptives or anti‐androgen therapy, subjects in each group were similar with respect to age at menarche and incidence of menstrual irregularity or amenorrhoea. Reports of excessive body hair, and clinical hirsutes on examination were few and there were no significant differences between acne severity groups. No correlation was observed between acne and hirsutes grades in all subjects (rank correlation coefficient = 0.096). Mild male pattern androgenic alopecia occurred in similar proportions of subjects in the three groups. Female pattern androgenic alopecia was observed in only two subjects.We have shown no correlation between acne severity and clinical markers of androgenicity in women. This suggests that in most cases factors other than hyperandrogenaemia are necessary for the development of a

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb03494.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

SUMMARYA family with a clinical variant of Papillon‐Lefèvre syndrome (PLS), associated with recurrent pyogenic infections, has been followed up for more than 20 years. Of the five living siblings, four were treated with etretinate for a period of at least 21 consecutive months. Clinical follow‐up showed that the course of recurrent infections in susceptible PLS patients, although usually more severe in childhood, can be variable and unpredictable. The etretinate therapy resulted in marked improvement of the keratodermas, and was associated with complete remission of the pyodermas on both keratotic and non‐keratotic skin. It is, therefore, suggested that etretinate may have a primary role in the prevention of recurrent pyogenic infections in susceptible PLS pa

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb03495.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

SUMMARYThe effect of topically applied active vitamin D3on epidermal regeneration was studied in eight healthy volunteers following sellotape stripping.The mobilization of resting (G0) cells was assessed by means of DNA flow cytometry, using a narrow window in the mid‐S phase to monitor the progress of the recruited cells. Although vitamin D3was applied at a concentration exceeding the range reported to be effective in psoriasis, we were unable to find any effect of active vitamin D3on G0mobilizationin viv

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb03496.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

SUMMARYWe carried out a clinicopathological study of epithelial cutaneous lesions induced in Dunkin‐Hartley albino guinea‐pigs by means of the topical application of 7,12‐dimethyl‐benzanraccne. By the end of the study we had observed 4451 lesions. Most frequently observed were epithelial hyperplasia and dysplasia (2544 lesions). Neoplasias consisted of 244 carcinomasin situ, and 88 squamous carcinomas. Basal‐cell epitheliomas were few. Epidermal cysts were a frequen

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb03497.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

SUMMARYThe efficacy of the 5‐HT‐2‐receptor antagonist, ketanserin, in the treatment of Raynaud's phenomenon was assessed in a double‐blind, placebo‐controlled, crossover trial in nine patients with generalized scleroderma (GS). Each patient received ketanserin 20 mg or placebo three times a day in the 1st week and 40 mg ketanserin or placebo three times a day for the remaining 4 weeks, and was then crossed over for 5 weeks. Measurements were made of finger blood pressure and flow during a cold challenge test and patients recorded numbers of Raynaud's attacks.No significant improvement was found in reactions to cold provocation or in numbers of Raynaud's attacks during ketanserin treatment, but intolerable side‐effects were common. Interactions with concomitant medication might be a possible explanation for this. We conclude that ketanserin in the dose given, is not effective in the treatment of Raynaud's pheno

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1988.tb03498.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY