摘要:

SUMMARYOn the basis of clinical, histological and electron microscopical findings, we are proposing that mycosis fungoides can begin in the epidermis. Early involvement of the basal layer of the epidermis is emphasized by the pigmentary changes which herald the onset of about half the cases. The formation of new fibrous tissue above the subepidermal elastic garland and the presence of PAS‐positive globules above the epidermal basement membrane, support the view that the primary change is on the epidermal side of the elastic garland and basement membrane. The predominantly epidermal distribution of the mycosis cell in many early cases suggests that it stems from a cell normally present in the epidermis. The likeliest candidate appears to be the Langerhans cell. A derivation from this cell would explain many puzzling features of mycosis fungoides and in particular the affinity of the mycosis cell for the epidermi

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb15444.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYEleven pregnant patients with neurofibromatosis have been studied. They have had twenty‐four pregnancies. Ten of these patients developed hypertension during their confinements. In the eleventh patient records were inadequate for analysis. In five of the ten patients, lesions of neurofibromatosis appeared for the first time during pregnancy. In the others the lesions increased in size and number. The lesions regressed considerably after delivery. It would seem that the hypertension during these pregnancies is more than a chance associatio

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb15445.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYThis paper describes the occurrence of pemphigus vulgaris in a 46‐year‐old female with a thymic tumour. The myasthenia gravis went into remission within a few months of thymectomy, but the patient continued to need steroids for pemphigus vulgaris for a further 5 years. The histological appearances of the thymic tumour and skin and the serological findings are descri

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb15446.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYThe development of pemphigus and bullous pemphigoid antigens in twenty‐nine human foetuses aged 9–40 weeks has been examined by immunofiuorescence. Pemphigus antigen was weakly demonstrable in the epidermal intercellular area at 9 weeks and strongly after 12 weeks, Bullous pemphigoid antigen was weak and patchy at 12 weeks and only consistently demonstrable with bright linear immunofiuorescence of the basement membrane zone after 23 weeks. Morphologically detectable epidermal basement membrane is already present by 9 weeks gestat

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb15447.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYThe carbohydrate tolerance was routinely investigated in fifty‐two patients with granuloma annulare. Thirteen of the fifty‐two cases presented the generalized type and the remaining thirty‐nine had the localized form of the disorder. The results obtained in these patients were compared with those revealed in two control groups of patients. The same number of patients of the same sex, age and ethnic group with skin diseases other than granuloma annulare were similarly investigated as were 386 patients with conjunctival micro‐aneurysms. Some degree of carbohydrate intolerance was detected in 36.5% of patients with both types of granuloma annulare. However, the incidence of this disturbance in patients with the localized form was no greater than in those with other skin diseases. The important finding in this study was the 76.9% incidence of carbohydrate intolerance in generalized granuloma annulare. This finding was supported by the histopathological changes in the small cutaneous blood vessels of these p

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb15448.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYA pedigree from a family with hyperkeratosis lenticularis perstans which shows a pattern of dominant inheritance is presented. This would appear to be the second occasion in which this condition has been shown to have a genetic basis. This family in addition shows a high incidence of cutaneous carcinomata, not arising in the keratosis. The possible significance of the association is discussed.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb15449.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYA study has been made of the transepidermal water loss and its sodium and potassium content in normal and psoriatic skin. The results show a preservation of the electrolyte barrier in active psoriasis despite serious impairment of the water barrier.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb15450.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYThe mean iron content of finger‐nails of 113 apparently normal subjects was found to be 67.6μg/gdry nail (±43.7). There was no age or sex variation. No relationship was found between the concentration of iron in finger‐nails and that stored in the

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb15451.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SummaryEpidermal cell migration occurs at the edges of human skin fragments when these are placed in a suitable medium containing serum. In this investigation, in which seventy‐four skin explants were used, it was found that cytochalasin B reversibly inhibited this migratory process. Inhibition was observed at concentrations of greater than 2μg/ml, and only in a small proportion of explants cultured in the presence of cytochalasin at a concentration of Iμg/ml. The reversible inhibition of cell movement by cytochalasin B has been thought due to the disruption of cytoplasmic microfilaments and it is possible that this is the mode of action of this substance on the epidermis as w

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb15452.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SummaryBy studying the sebum excretion rate in patients with Parkinsonism before and during treatment with L‐dopa we have shown that L‐dopa reduces sebum excretion if seborrhoea is initially present, but has no effect on normal sebum excretion rates. The seborrhoea of Parkinsonism may be due to increased production of melanocyte‐stimulating hormone, and our finding may have therapeutic implications in Parkinsonism and breast c

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb15453.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY