摘要:

SUMMARYA family with hereditary hypotrichosis congenita of Marie Unna type, with 4 affected members in 3 generations, is reported.The affected individual is born almost or completely hairless. Hair grows during the first months or years of life but begins to fall at about the age of puberty. The scalp hair is mainly coarse, of large calibre and irregularly twisted. Lashes and eyebrows and body hair are sparse.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15711.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARYFour white South African families (9 patients) with lipoid proteinosis were genealogically investigated. All 4 families could be traced to a brother and sister who came from Germany and settled in South Africa in the seventeenth century.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15712.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARYA study has been carried out in 20 members of 5 unrelated families to confirm the diagnosis of hypohidrotic ectodermal dysplasia (HED) in 5 young males, and to detect possible female carriers. The history and the clinical examination were supplemented by sweat testing and plastic imprinting over selected areas of the palm, pore‐counting, and dermatoglyphic analysis. Findings of importance include definitely abnormal imprints in 3 mothers and in 4 affected individuals, good sweat gland function in one of the affected individuals, and unilateral or bilateral high maximal and angles in all affected individuals and in 4 mother

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15713.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARYA high incidence of positive patch tests to merthiolate (thimerosal) has been observed in young adult males without previous or present skin disease. In battery‐tested clinical material several positive merthiolate tests occurred, mainly in the younger age groups, while a high‐age group did not react even to a strong merthiolate patch test. Although the clinical and histological features of the reaction are mainly of an allergic type, evidence is presented that the merthiolate reaction should be considered a false positive test, peculiar to that substance and to young s

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15714.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARYTwo cases of fixed drug eruption due to tetracycline derivatives are presented. In view of the vast consumption of these drugs it is surprising that this reaction is not recorded more frequently.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15715.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARYA method is described for the measurement of cutaneous adenyl cyclase. Certain properties of the adenyl cyclase of guinea‐pig skin have been studied; this enzyme appears to be unusual in that no stimulation of its activity by adrenalin could be demonstrate

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15716.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARYAdenyl cyclase activity was measured in biopsy specimens from the lesions of atopic dermatitis, from atopic “uninvolved” skin, and from the skin of healthy controls. No decrease in the level of this enzyme was found in the ato

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15717.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARYThe sweat response to iontophoresis with pilocarpine was measured in the clinically normal skin between the lesions of psoriasis and in normal‐looking skin of a control group of subjects. The sweat rate was found not to be affected by complete removal of the stratum corneum either in the normal‐looking skin of patients with psoriasis or in the healthy skin of control subjects. It is concluded that sweat duct occlusion is not a feature of normal skin or of the skin between the lesions of psoria

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15718.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARYThe Cartesian diver microgasometer was used to study the oxygen consumption in microdissected samples of the basal parts of epidermis. Specimens were taken from guttate lesions and uninvolved skin of psoriatic patients and also from subjects without psoriasis. Incubations were performed in TC 199 phosphate medium supplemented with either 5·6 mM glucose, 20 mM pyruvate or oxalacetate and/or 10 mM sodium succinate. Without supplements to the medium the oxygen consumption averaged 16 mmol./hr. and kg. dry weight and no differences were found between the normal epidermis and the 2 types of psoriatic epidermis. Addition of glucose or pyruvate did not change the rate of respiration. In normal epidermis and in the unaffected epidermis from patients with psoriasis the oxygen uptake increased by a factor of 1·5 after addition of succinate. A much more intense stimulation was obtained by succinate in the guttate psoriatic lesion2the oxygen consumption in these experiments increased by a factor of 6·8. Oxalacetate did not influence the respiration in the absence of succinate, but a strong inhibitory effect was evident in all epidermal groups studied after addition of succinate. The results indicate that in the psoriatic lesion the cells have a considerable capacity for metabolic energy producti

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15719.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARYCopper and zinc levels were estimated in skin biopsies from a group of 20 psoriatic patients and compared with those of 10 normal subjects. The concentrations of zinc in psoriatic epidermis and dermis were significantly higher than normal, while those of copper were not. The levels of these 2 trace elements were also determined in the serum of 23 psoriatic patients and 22 normal subjects. There was a significant increase in serum copper levels in the psoriatic group. Zinc levels did not show significant variations.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15720.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY