摘要:

SUMMARYOut of 98 female referrals with acne vulgaris it was possible to define ovarian morphology by high resolution ultrasound imaging of the pelvis in 82 (84%). Sixty‐eight (83%) were shown to have polycystic ovaries, compared with 19% in a control group without acne. The presence of polycystic ovaries in the acne patients did not correlate with acne severity, infertility, menstrual disturbance, hirsutes, or biochemical endocrinological abnormalitie

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1989.tb08208.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

SUMMARYAdults with atopic dermatitis (AD), with respiratory atopy only and healthy non‐atopic controls were given intradermal injections of substance P (SP), neurokinin A (NKA), neurotensin (NT), vasoactive intestinal polypeptide (VIP), calcitonin gene‐related peptide (CGRP) and histamine into the normal‐appearing skin on the back. The weal and flare responses were evaluated after 3, 5 and 15 min and the areas calculated using an automatic image analyser. With the three different concentrations used (1,3 and 30 pmols) a statistically significant (P<0·05) reduction in both the weal and flare response to SP, NKA, NT and histamine and a reduced flare to CGRP was observed only in AD patients. Among those with AD there was no uniformity of response to the individual neuropeptide and in general the more severely affected showed a lower reactivity. Dose‐response relationships were evaluated for SP and NT (10–320 pmols) in AD and healthy controls. In AD dose‐response curves and time‐course relationships were similar to controls, but at significantly reduced levels. The itch response to the neuropeptides and histamine was not different in atopics and controls. We suggest that this hyporesponsiveness in AD is the result of natural tachyphylaxis of the target structures (mast cells and blood vessels) and possibly due to a higher availability of neuropeptides in the skin or to a primary abnormal sensitivity of the blood vessels and mast cells to

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1989.tb08209.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

SUMMARYImages of the hamster flank organ were obtainedin vivoby high resolution ultrasound (B‐scan). The planimetric measurements of the ultrasonic image that determined the size of the flank organ, with a reproducibility of about 10%, highly correlated with the measurements of histological sections. This new method provides a simple and non‐invasive method for determining the size of the hamster flank organ after various treatments which does not involve the killing of the animal under investigat

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1989.tb08210.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

SUMMARYRecombinant human interleukin 1 beta (IL‐1β), given intraperitoneally to mice as a single injection, significantly suppressed the development of arachidonic acid (AA)‐induced ear oedema. This effect was noted 2 h after administration and for at least 5 days afterwards. IL‐Iβ was effective in the dose range of 250 ng‐20 μg/mouse. Injection of IL‐1βper seresulted in erythema of the ears, and thus, IL‐1β has the capacity not only to induce and augment but also to suppress inflammatory responses. Indomethacin administered as subcutaneously‐implanted pellets did not influence the IL‐1β induced‐ear erythema, but suppressed to some extent the eflect of IL‐1β on

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1989.tb08211.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

SUMMARYThe effect of site on the irritant dermatitis potential was studied in 10 subjects using the volar surface of the forearm. Erythema scoring and transepidermal water loss (TEWL) measurements were used to assess irritation at different levels on the forearm. A sodium lauryl sulphate (SLS 2 g/v%) solution was used as a standard irritant in a patch test procedure and on open tests. Both the erythema scores and measurements of the TEWL of exposed skin showed significant localization differences, and demonstrated that the same sites on the forearm should be used for irritancy tests and possibly physiological studies.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1989.tb08212.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

SUMMARYWe report our studies on the cutaneous and plasma fibrinolytic activities (FA) in nine patients with Behçet's disease (BD) as compared with nine normal controls. The euglobulin lysis time of the plasma and cutaneous fibrinolytic activity were determined in these patients. The studies showed that the plasma fibrinolytic activity was reduced in the patients with BD and there was impaired cutaneous fibrinolytic potential, tPA dependent, in those patients with venous and arterial thromboses

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1989.tb08213.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

SUMMARYWe report seven examples of pigmented spindle cell naevus (PSCN) and variants, emphasizing their histopathologic differentiation from malignant melanoma (CMM). Confusion with CMM may occur because of upward migration (pagetoid spread) of cells, prominent lateral extension of lentiginous melanocytic hyperplasia, and cytological atypia in spindle cell naevi. However, these proliferations are usually associated with a symmetrical and orderly growth pattern, confinement of the pagetoid spread to the lower epidermis,‘maturation’of the dermal component, and lack of marked cytological aty

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1989.tb08214.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

SUMMARYThe prevalence and pattern of mucosal involvement in 121 patients with lupus erythematosus (LE) was investigated. Fifty‐three patients had systemic LE (SLE) and 68 patients had chronic cutaneous LE (CCLE). Twenty‐one per cent (11/53) of patients with SLE and 24% (16/68) of patients with CCLE had signs of mucosal involvement, but the pattern of involvement differed in the two groups. Nasal mucosal lesions were a feature in 2% (1/53) of patients with SLE and 9% (6/68) of patients with CCLE. Hyperkeratotic lichen planus‐like plaques on buccal mucosa and the palate occurred in 9% (6/68) of patients with CCLE and 4% (2/53) of patients with SLE. Episcleritis occurred in 9% (5/53) of patients with SLE and was not seen in CCLE. Erythematous plaques on the lower eyelids were present in 6% (4/68) of patients with CCLE and these were associated with conjunctival scarring in two patients. Vulval lesions were present in 5% (2/42) of female patients with CCLE. Oral plaques may occur when the disease is relatively quiescent elsewhere. The prevalence of mucosal involvement in lupus is underestimated as the lesions may be asympto

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1989.tb08215.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

SUMMARYThe prevalence and clinical significance of subepithelial immunoglobulin and complement deposition (the lupus band) were examined in the uninvolved sun‐protected skin of the forearm, the uninvolved sun‐protected lip mucosa and sun‐protected bulbar conjunctival mucosa in systemic lupus erythematosus (SLE) and chronic cutaneous lupus erythematosus (CCLE). In SLE, linear deposition of an immunoreactant at the BMZ was detected in 32% (6/19) of skin biopsies; 21% (4/19) of lip mucosal biopsies and 42% (5/12) of conjunctival biopsies. There was no significant difference in the sensitivity of the test at different sites in SLE and no correlation between a positive test in skin, lip or conjunctiva and clinical mucosal involvement. In CCLE, linear deposition of an immunoreactant at the BMZ was found in 3% (1/32) of skin biopsies; 3% (1/29) of lip mucosal biopsies and 50% (10/20) of conjunctival biopsies. There was no correlation between a positive test in skin, lip or conjunctiva and clinical mucosal involvement. In the conjunctiva, IgG was present in all but one of the biopsies and was the only immunoreactant in 90% (9/10) of positive CCLE biopsies and 60% (3/5) of positive SLE biopsies. In lupus erythematosus immunoreactants may be deposited in the basement membrane zone beneath non‐keratinizing mucosal surfaces of the lip and the eye as well as the skin. In CCLE, the test may be positive in conjunctiva when skin and lip are n

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1989.tb08216.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

SUMMARYWe report on the use of a new orally active fungicidal agent, terbinafine (SF 86–327, Lamisil) in the treatment of patients with dermatophyte onychomycosis. Twenty patients with toe‐nail, and 10 with finger‐nail infection received 250 mg of terbinafine daily: finger‐nail infections were treated for 6 months and toe‐nail infections for 12 months. All 24 patients who completed the course of therapy achieved mycological cure, as did two subjects who dropped out of the trial. All but two patients had clinically normal nails at the end of the study period. The mean time for mycological cure was 12.5 weeks for finger‐nail infection, and 24 weeks for toe‐nail infections. The time for a clinical cure with normal nails was 20.5 weeks for finger‐nail infection, and 44 weeks for toe‐nail infection. An exacerbation of pre‐existing dyspepsia occurred in three of the six patients who did not complete the trial but there were no other significan

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1989.tb08217.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY