摘要:

SUMMARY.—Two patients with subcorneal pustular dermatosis are presented. No qualitative or quantitative changes of the serum proteins were revealed by immunoelectrophoresis and radial immunodiffusion.Microtome sections of frozen blister specimens were incubated with human red cells (O Rh‐negative). The erythrocytes adhered to the stratum corneum composing the roof of the blister. This reaction was inhibited by conglutinin. The blister fluid selectively lacked antibodies to stratum corneum. These results suggest the formation of antigen/antibody/complement complexesin vivo. At least part of the tissue damage in subcorneal pustular dermatosis may be immunologically media

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15075.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.—Thein vivodirect immunofluorescent (DIF) staining patterns of the skin surrounding the lesions of 5 patients suffering from pemphigoid are reported.It appeared that fine granular IgG deposits occur in the dermis and more closely packed in the junctional zone of most of the biopsies examined. Only 1 case with a very high (anti‐basement membrane) IgG antibody titre showed a conspicuous linear fluorescence of the basement membrane zone, while 2 other cases with a less high antibody litre showed both types of staining patterns. The impression was gained that there is some relation between the antibody litre and the DIF staining pattern in DH.The findings of this study are also in favour of the concept that pemphigoid and dermatitis herpetiformis are 2 different disease entities; however the existence of intermediate cases cannot be ruled out.The advantages of the DIF method are discussed. An improved filter combination for blue narrow‐band excitation and a rigid control of the conjugates used for IF studies are recomm

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15076.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.—Clinical, histological and ultrastructural features of digital fibrous swellings in children are described. The clinical progress of these cases indicates that the lesions tend to regress spontaneously, and that they are recurrent only in the sense that growth may continue after incomplete surgical excision. A characteristic feature of the lesions is the occurrence of cells with dense cytoplasmic deposits. These cells appear to be abnormal fibroblasts, but electron microscopy provides no clues as to the origin, nature, or causation of the cytoplasmic deposits. No evidence was obtained to support a suggestion that the lesions may have an infective viral origin. Elastic fibres were very scarce within the swellings, and showed some evidence of abnormality. Collagen fibres, constituting the bulk of the swellings, appeared essentially norma

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15077.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.—Composition of the skin surface lipids of rats aged 3–14 weeks was analysed with thin‐layer and gas‐liquid chromatography. It was found that hypophysectomy of female rats aged 3 weeks was followed by distinct changes in the relative amounts of both the unhydrolysed lipid fractions and the different fatty acids. The changes in composition brought about by testosterone treatment in the hypophysectomized animals and by age in the intact male rats were in many respects parallel with each other and opposite to the changes caused by hypophysectomy. The pre‐hypophysectomy composition was not, however, completely restored by testosterone or by simultaneous treatment with both testosterone and oestradiol. Oestradiol had no clearly specific effect on the composition, but growth hormone given to the hypophysectomized animals appeared to give partial protection against the changes in composition produced by hypophysectomy.The ratio of palmitic to stearic acid was found to be of value as an indicator of the activity of the sebaceous glands. There was a good positive correlation between this ratio and the production rate

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15078.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.—Studies show that the lipid on the surface of the skin above the right scapula varies in relationship to the menstrual cycle. The cholesterol level increases at mid‐cycle whereas the triglyceride level rises continuously throughout the menstrual cycle until the onset of bleed

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15079.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.—Slices of skin from human subjects have been shown to transform3H‐dehydroepiandrosterone predominantly to 4‐androstene‐3,17‐dione and 5‐androstene‐3β,17β‐diol. Testosterone, testosterone sulphate and dehydro‐epiandrosterone sulphate were not formed in detectable amounts under the conditions of the investigation. Skin from the shoulder appeared significantly more active than that from the thigh or axilla in metabolizing the dehy

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15080.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARY.—A case of apocrine sweat gland carcinoma in a man aged 78 is presented. The patient died of widespread huematogenous metastases. Enzyme histochemical findings were important for the final identification of the tumou

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15081.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15082.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15083.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1970.tb15084.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY