摘要:

SUMMARYPhospholipase A and lyiophosphohpase activities have been demonstrated in cow snout epidermis. The phospholipase A activity was dependent on Ca2+ions and the pH for optimum activity was between 6.1 and 7.4.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03138.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYParameters of humoral and cellular immunity were measured in thirty‐five patients with atopic eczema. The mean serum IgE level was raised but levels of the other major immunoglobulin classes were normal. Ten per cent of patients failed to respond to tetanus immunization. All patients responded toS. typhiH antigen. Fourteen per cent of patients failed to mount delayed hypersensitivity reactions to a battery of three intradermal antigens. The phytohaemagglutinin‐stimulated uptake of3H thymidine by lymphocytes was normal in the presence of autologous or of fetal calf serum, as was the spontaneous lymphocyte uptake. T and B lymphocyte numbers in the peripheral blood were normal. These results are similar to those found in asthmatic patients and support the hypothesis that, in some patients, atopic eczema is associated with an immunodeficiency st

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03139.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYWhen epidermis from the uninvolved skin of psoriatic patients was incubated for 5 min in Hank's medium containing adrenaline and theophyllinc, the cychc AMP level consistently increased 20‐30 times over the level observed when adrenaline was not added to the medium. On the other hand, when epidermis from the involved skin of psoriatic patients was incubated under the same experimental conditions, the cyclic AMP level increased only 2–5 times. Even when thcophylline, an inhibitor of specific cyclic AMP‐phosphodiesterase, was omitted from the medium, a clearly demonstrable difference in sensitivity to adrenaline was evident in normal appearing and lesional psoriatic epidermis. These results indicate a faulty adenyl cyclase system in the involved epidermis of psoriatic lesions rather than a defective degradation process by the specific phosphodiesterase. Since the Km for adrenaline activation of adenyl cyclase was approximately the same in both the uninvolved and the involved epidermis and since the cyclic AMP increase by adrenaline was abolished by the addition of propranolol, the basic nature of the β‐receptor (specifically the binding affinity to adrenaline) in the involved epidermis does not appear to be defective. On the other hand, the finding that the Value, for adrenaline activation is 10–20 times higher in the uninvoled than in the involved epidermis suggests that the poor response in the involved epidermis may be due to fewer available binding sites for adrenaline in the psoria

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03140.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYThe incidence of viral warts, recurrent herpes simplex and herpes zoster has been assessed in a group of patients with possible secondary immune deficiency states and compared to a control group. Patients with cell‐mediated immune deficiency appear to be more prone to warts and zoster infection as compared to patients with humoral immune deficiency. Recurrent herpes simplex infection was not increased in either grou

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03141.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYThe loss of intercellular and basement membrane amigens has been associated with the development of epidermal cell dysplasia and ncoplasia. The antigenic components of the epidermis have been investigated in lichen planus, lupus erythematosus and eczema, using pemphigoid and pemphigus sera by the indirect immunofluorescent staining method. In areas of active lichen planus there was extensive reduction or complete absence of basement membrane antigen. Intercellular antigen was preserved in lichen planus although in some damaged retc ridges it appeared to be reduced. Both these antigens were well preserved in lupus erythematosus and eczema. Loss of epithelial antigens is therefore not confined to the development of neoplasia.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03142.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYHyaline or colloid bodies (Civatte bodies) and amyloid are sometimes confused because of their similar appearance under the light microscope. A differentiation can be made by histochemical means (DMAB Nitrite method) and by fluorescence or polarization microscopy.At the ultrastructural level hyaline or colloid bodies as well as amyloid exhibit a fibrillar structure, but can be differentiated by the diameter and arrangement of fibrils and the localization of the aggregations. A clearcut differentiation between hyaline or colloid bodies and amyloid seems of great importance in any discussion of the epidermal origin of amyloid and the classification of fibrillar aggregations associated with skin tumours.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03143.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYThe prekeratin of the snout of cows was extracted with 0.1 mol/1 citric acid‐sodium citrate buffer, pH 2.6. The results of equilibrium ultracentrifugation analyses of this prekeratin strongly suggest that this protein is not homogeneous. This conclusion is in accordance with the observations of two other investigators whose data infer that there is no major homogeneous keratin precursor in cow's lip or snout epidermi

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03144.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYA method is described which enables measurement to be made of the roughness of the surface of skin surface biopsies. The instrument used in this investigation has previously been employed to measure the degree of unevenness of metal and ceramic surfaces and is called a ‘surfometer’. Using this technique the tracings that resulted from examination of normal skin, psoriasis and certain ichthyotic states could easily be distinguished. It was also demonstrated that there was a consistent pattern of change with increasing hydration of the stratum corncum in the absence of easily identifiable morphological alterati

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03145.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYThe adnexal polyp of neonatal skin is a small, usually solitary tumour of the skin occurring mostly on theareolaof thenippleof theneonate. Our statistics reveal an incidence of 4.0%, in 3,257 newborn infants. Histologically it always contains hair follicles, eccrine glands and vestigial sebaceous glands, hence the term ‘adnexal polyp of neonatal skin’ is proposed. No similar report has been hitherto recor

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03146.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYSeven guinea‐pigs were inoculated intravenously with a rich suspension ofLeishmania enricitii. During the sixth to the seventh week from inoculation, all of them developed lesions within the anrcrior nasal mucosa and in the vulva or scrotum. In one animal nodules occurred in the forepaws during the tenth week. The histology of the latter showed an cpithclioid granuloma with multinucleate giant cells, while in all the others macrophages and monocytes highly parasitized with leishmania bodies, formed the main elements in the granulomatous infiltrate. Lesions seem to develop in the cool, non‐hairy areas of the integument and those areas of the nasal mucosa which are constantly bombarded by the inhaled cool air stream. The anterior nasal mucosa, with its leaking venular network, its cool temperature, relative stasis and hypoxia probably provides the optimum micro‐environment for the localization, survival and multiplication of tho leishmanial prot

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb03147.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY