摘要:

summaryEleven of thirty‐two patients with cutaneous vasculitis had anticomplementary sera. Five of the eleven anticomplementary sera contained immune complexes in the form of mixed cryoglobulins. The anticomplementary activity in the sera of these patients suggests that the vasculitis may be due to circulating immune complexe

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07579.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

summaryThe presence of telangiectatic lesions on the arms of patients who suffer from thyroid diseases is described and the histology of the lesion illustrated. The incidence of this abnormality was found to be 23% in patients attending a thyroid clinic as compared with 1% in patients attending a dermatological clinic.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07580.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

summaryWater loss and carbon dioxide release measurements were performed to determine whether the severity of damage to human skin, caused by exposing its surface to buffered and unbuffered solutions of alkali and sodium phosphate, could be evaluated simultaneously by means of different measuring techniques and whether the results of these measurements, expressed in numerical terms, gave identical information.It appeared that the buffered solutions disturbed skin functions less than the unbuffered solutions and therefore may be considered to be less harmful. The NaOH solution at pH 12.0, lacking any buffering capacity, damaged the skin, producing signs of inflammation, whereas that at pH 10.0 did not.It appeared that skin damage could be assessed reliably by simultaneously measuring changes in skin impedance, water loss and carbon dioxide release, which are interrelated parameters.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07581.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

summaryFresh, not chemically fixed, glycerol‐cryoprotected material from skin lesions of histiocytosis‐X (Letterer‐Siwe disease) was examined by the freeze‐fracture technique. Fracture appearances of the cytoplasmic X‐granules characteristic of cells of histiocytosis‐X were established, and the accuracy of previous three‐dimensional reconstructions of variations, in overall shape of granules based upon stained thin sections was confirmed. These variations, therefore, are not artifacts of conventional tissue processing. Little or nothing of the internal structure of X‐granules is seen in replicas, and the technique provides no new information concerning their origin or mo

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07582.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

summaryConventional methods of testing patients, with cold urticaria are unsatisfactory. In this report we have described an instrument which exposes a circular area of skin 33 mm in diameter to 0° C fo 2 min. The response is recorded in terms of the maximum diameter of erythema which follows and of the duration for which this erythema persists. The flexor surface of the forearm was selected as a convenient site, and the responses from the two forearms were found to be almost equal. The response in most of the fifty normal controls and in twenty‐four patients with urticaria of unknown origin consisted of an erythema less than 38 mm in its maximum diameter, lasting for less than 3 min. In twenty‐eight of thirty‐two patients clinically thought to have cold urticaria the response was exaggerated, either in the extent of erythema or in its duration or in both. Only one patient developed a weal. This test is thus considered to be useful in confirming the diagnosis of cold urticaria. The incidence of false positive and false negative reactions is quite low and can be minimized by the exclusion of certain factors which influence th

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07583.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

summaryA simple new method of producing experimentalTrichophyton rubruminfection in man is discussed. A suspension of fresh culture using a granular colony was applied under occlusion on areas of skin. Occlusion was removed after 5 days and a semi‐occlusive dressing applied. It was possible to induce typical ringed or discoid lesions, which could persist for a long time if semi‐occlusive dressings were continuously appl

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07584.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

summaryUtilizing the skin window technique, symmetry of cellular response was examined by comparing cellular exudates from symmetrical areas of opposite forearms in eleven subjects. Testing the hypothesis that there would be no significant difference between symmetrical sites subjected to the same stimulus at the same time, the percentages of cell types in the cellular exudate were calculated for 126 paired comparisons. A significant difference in the cell types arriving at the skin window sites occurred in seventy‐six out of the 126 paired comparisons (Chi square analysis, P<0.01). This lack of a symmetrical response could be due to an inherent variability of the cellular response or to an inability to manipulate the two sites in exactly the same manner.Although significant differences were found between the above individual matched pairs (Chi square analysis), the ‘t’ test analysis of the pairs grouped by hour revealed no significant difference in mean percentages of cell types between left and right arms at fourteen time intervals. Thus, previous skin window investigations comparing mean percentages of cell types were found to be valid, even though symmetry of cellular response in individual subjects is much less than exp

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07585.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

summaryNormal control and apparently unaffected skin from psoriatics have been compared quantitatively for their acid phosphatase activity. The unaffected skin from psoriatics shows a more rapid reaction, which may be related to a lysosomal defect.No marked differences were detected in the dehydrogenase reactions in these two tissues. However, in frankly involved psoriatic skin it has previously been shown that there is a marked increase in glucose‐6‐phosphate dehydrogenase activity in the transitional zone. In the present report an increase in glycero‐phosphate dehydrogenase activity has been demonstrated in the lower portion of psoriatic epid

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07586.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

summaryBiopsies have been taken from the involved and uninvolved skin of eleven patients with psoriasis and the normal skin of six patients without psoriasis, 1 h afterin vivoinjection of 10 μCi of3H‐thymidine. Mitotic counts and counts of labelled cells (synesizing DNA) after autoradiography have been carried out. The ratio of mitoses to labelled cells was 1: 25 in clinical psoriasis, 1: 190 in uninvolved psoriatic epidermis and 1: 450 in normal epidermis. The number of labelled cells in clinical psoriasis was approximately 12 times greater than normal epidermis. However, the number of labelled cells in uninvolved psoriatic epidermis was approximately twice that of normal. These results imply an alteration in the components of the cell cycle in both involved and uninvolved psoriatic epiderm

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07587.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

summaryThe normal buccal mucosa was analysed by application of Lowry's microtechniques in thirteen psoriatic patients with guttate skin lesions and in fifteen healthy controls, for the following enzymes: glucose 6‐phosphate, glycerol 3‐phosphate and glyceraldchydc phosphate dehydrogenases, pyruvate kinase (PK) and NAD and NADP dependent isocitrate dehydrogenases. The material was obtained from superficial and adjacent basal parts of the epithelial rete ridges. Enzymatic activities were higher in basal than in superficial epithelium except for PK in controls. The PK activity was lower in the psoriatic patients than in the controls when the superficial epithelium was compared. No differences were found between the controls and the psoriatic patients with regard to activities of the other five enzymes measu

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb07588.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY