摘要:

SUMMARYIndirect immunofluorescence (IIF) and double immunodiffusion (DID) were performed on the sera of 64 patients who had a nucleolar immunofluorescence pattern on HEp‐2 cells. Forty‐nine of the sera were from 296 patients with systemic scleroderma (SSc) and 15 sera were from 214 patients with systemic lupus erythematosus (SLE). A homogeneous nucleolar staining pattern was found in 45 of the 64 sera (70.3%), a clumpy fluorescence associated with fibrillarin antibody in 14 (21.8%) and a speckled pattern was found in five of the sera (7.8%).There was a clear correlation between the sera which showed a homogeneous nucleolar staining pattern with symptoms of the polymyositis/scleroderma overlap syndrome that differed from SSc with concomitant myositis. The clumpy pattern was mainly associated with diffuse scleroderma and the speckled pattern with limited scleroderma (previously called acroscleros

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb01445.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

SUMMARYEndemic pemphigus foliaceus or fogo selvagem (FS) is a blistering autoimmune disease indigenous to certain states of Brazil. In the state of Parana the disease has been reported in the north‐central regions where a total of 632 cases were documented in the period of 1940–80. The present study describes a new focus of FS in the western region of the state of Parana. This focus includes a total of 213 new cases of FS and only 11 cases of pemphigus vulgaris seen in this region from February 1976 to July 1988. Over 90% of these patients were peasants working in agriculture or involved in other outdoor activit

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb01446.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

SUMMARYIn a case control study, the incidence of malignant disease in 84 patients with bullous pemphigoid (BP) was compared with 168 controls. The rate of malignant disease (past, concurrent or during follow‐up) in BP patients was 17.9% compared to 5.3% in the controls. A number of the malignancies occurring in the BP group may be of doubtful significance, being either temporally very remote or partially attributable to treatment. The rate of concurrent BP and malignancy (within 8 weeks) was 6.0% suggesting that there is probably a slight excess of malignancy in BP, but insufficient to warrant extensive investigation in pursuit of cancer. Comparison of the BP patients with and without cancer identified no clinical or immunopathological subgroups in whom investigations would be indicated. Three patients with both BP and malignancy were HLA‐DR 13 positive, which may point to an immunogenetic predisposition to both disea

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb01447.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

SUMMARYSeventy patients with linear IgA disease of adults were followed up for a mean of 8.5 years and all malignant diseases in this group were ascertained. There were three cases of lymphoproliferative malignancy, which constituted a significant excess over the 0.2 cases that would be expected by comparison with an age‐ and sex‐matched population using National Cancer Registry statistics. In contrast, the non‐lymphoid malignancy rate of 13% is almost identical to the expected 14%. A subgroup of 35 of the adult linear IgA disease patients were assessed with respect to the possible precipitating illnesses or drugs, as well as co‐existing medical conditions. Almost one‐third of patients described an event that was felt could possibly have triggered the linear IgA disease, the most frequent being non‐steroidal anti‐inflammatory or antibiotic drug therapy, trauma/burns and upper respiratory tract infections. However, it is difficult to determine how often the preceding event is coincidental, and how often, if at all,

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb01448.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

SUMMARYTo evaluate the possible association of malignant disease with chronic urticaria 1155 consecutive cases with chronic urticaria were reviewed. The Swedish Cancer Registry, Stockholm, was searched for records reporting malignancies in the study population (1958–1984), and the expected number of malignancies was calculated on the basis of age‐ and sex‐standardized incidence data. A malignancy was diagnosed in 36 patients with urticaria and the expected number of malignancies was 41. In 23 patients the malignancy appeared during the same year as the onset of urticaria or later. The expected number was 25.6. We conclude that chronic urticaria is not statistically associated with malignancy in ge

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb01449.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

SUMMARYTwo studies were designed to assess the effect of abrasive preparations on the skin and to test the specificity of the effect of topical tretinoin in the management of chronic photodamage to the skin. In the first study two abrasive preparations (Brasivol® fine and Brasivol® medium) were compared with white soft paraffin and no treatment in eight volunteer subjects for their effects on the epidermis. The study was conducted over 3 days and measurements were taken of the effects on dansyl chloride‐induced fluorescence to assess desquamation, epidermal thickness, and the tritiated thymidine autoradiographic labelling index. The abrasives were found to increase the desquamation rate significantly and to increase epidermal thickness and the epidermal labelling index compared to white soft paraffin and no treatment.In the second study the effect of one of the abrasive preparations (Brasivol® medium) was compared with 0.05% tretinoin cream (Retin A®) on the photodamaged skin of the dorsal aspects of the forearms of 12 subjects over an 8‐week period. Cutaneous blood flow measured by the laser‐Doppler flowmeter was found to be significantly increased in the abrasive‐treated sites, but there was only a non‐significant trend to increased blood flow in the tretinoin‐treated sites. Measurements of skin thickness using pulsed A‐scan ultrasound demonstrated that both treatments produced significant increases in thickness over the 8‐week period but the increase was greater for the abrasive treated site. Measurements of the skin extensibility at the treated sites were made using a uniaxial extensometer. Forces needed for 30% skin extension were increased in the abrasive‐treated sites only. Measurements of epidermal thickness and of [3H]‐thymidine autoradiographic labelling indices showed greater increases in the abrasivetreated sites than in tretinoin‐treated sites compared to untreated sites, but these increases were not statistically significant.No significant inflammation and no changes in the degree of elastosis or the presence of a‘repair zone’ were found in any of the post‐treatment biopsies. The results indicate that some of the changes produced in the skin by topical tretinoin that are taken to indicate a specific antiphotoageing effect may not in fact be specific and can be achi

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb01450.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

SUMMARYWe have tested in two ways the hypothesis that dermal fibroblasts direct the hyperproliferation of the overlying epidermis in psoriasis. First, culture medium from psoriatic and from normal skin fibroblasts was added to monolayer cultures of foreskin keratinocytes. Second, psoriatic and normal fibroblasts embedded in hydrated collagen lattices were co‐cultured with monolayers of foreskin keratinocytes. There was no evidence in either study that psoriatic fibroblast products could stimulate the proliferation of the keratinocytes, or that normal fibroblast products inhibited their proliferation. A positive control for the fibroblasts was provided by leucocyte supernatants, which stimulated keratinocyte proliferation by up to 65%. Our data do not support a primary role for dermal fibroblasts in psoriasi

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb01451.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

SUMMARYDifferences in the dynamic skin friction coefficients (μ) were investigated with respect to age, sex, and anatomical region. A total of 29 volunteers consisting of seven young females, seven old females, seven young males, and eight old males participated in the study. Measurements were obtained from II anatomical regions, namely, the forehead, upper arm, volar and dorsal forearm, postauricular, palm, abdomen, upper and lower back, thigh, and ankle. The friction data were compared with stratum corneum hydration and transepidermal water loss (TEWL). The dynamic friction coefficient did not vary significantly between age and sex groups but varied considerably among the anatomical regions of the body. The forehead and postauricular had the highestμ(0.34 ± 0.02) while the abdomen had the lowest (0.12 ± 0.01); the remaining regions had an averageμvalue of 0.21 ± 0.01. Similarly, no sex differences were observed for TEWL and stratum corneum hydration. Capacitance was only significantly lower on the palms of the elderly. Regional differences showed a higher state of hydration on the forehead and postauricular as well as the upper arm, upper and lower back when compared with the volar forearm. TEWL was generally lower in the elderly on all anatomical regions except the postauricular and palm. A significant correlation was established betweenμand capacitance for most regions. Betweenμand TEWL significant correlation was observed only on the palm and thigh. These findings suggest that frictional properties of skin are dependent on more than water content or non‐apparent sweating and the role of sebum secretion is suggested as one possib

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb01452.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

SUMMARYA combination of alkali treatment and proteinase K digestion was used to solubilize nail samples from patients with onychomycosis treated orally with terbinafine. The samples were extracted and the levels of terbinafine and its metabolite measured by high‐pressure liquid chromatography. The results showed a relatively rapid penetration of terbinafine into normal nail plate, suggesting that diffusion via the nail plate is the primary route of entry into this tissue. The levels of terbinafine achieved in nail samples exceeded the range of MICs for dermatophytes at the earliest time point (4 weeks) tested in 50% of patients and remained stable, without accumulation, during periods of treatment of up to 3 month

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb01453.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

SUMMARYInterleukin 1 (IL‐1) in the epidermis plays an important role together with Langerhans cells in the activation of the T cells. To determine whether IL‐1 could be located in the normal epidermis of 54 patients with HIV infection and related to the stage of the disease, an indirect immunofluorescence technique was used. Intense epidermal fluorescence to IL‐1 was noted in the asymptomatic stage II of the disease, whereas there was minimal reactivity in the other s

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1990.tb01454.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY