摘要:

Summary.—The basement membrane antibodies in 3 sera of patients with bullous pemphigoid were studied by means of indirect immunofluorescent staining chessboard titrations on monkey, rabbit and guinea‐pig lip tissue. Comparisons of the results of these studies with those obtained in previous studies of this type with 2 other sera, revealed wide variations in the spectra of specificities of the bullous pemphigoid antibodies. Monkey oral or oesophogeal mucosa appears to be the substrate of choice for routine tests for these antibodies, although this must be regarded as an approximation of the “ideal antigen”.The implication of these findings are discussed both from the practical and theoretical points

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb16072.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—We have reported a case of severe bullous erythema multiforme type of fixed drug eruption in which (1) multiple drugs were erroneously first indicated as the cause; (2) a false positive bullous patch test was obtained and discovered to be an intracorneal artefact, reflecting a new phenomenon, epidermal hysteresis; (3) a relationship to auto‐sensitization and pemphigus was discerned by the demonstration of direct intercellular immunofluorescence in the lower epidermis of the affected fixed sites only; (4) phenolphthalein was finally proven to be the specific cause by double‐blind oral chal

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb16073.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—The ducts of the glands of Montgomery, usually in conjunction with sebaceous follicles, produce tubercles at the surface of the areola. The ducts and their glands are similar in every respect to those that open at the tip of the nipple, except that the former are not surrounded by nerve end‐organs. We therefore suggest that Montgomery glands are integral parts of the mammary system. In all of the numerous areolae observed, we found only a single, minute hair follicle, and no apocrine sweat glands. Those “glands” previously described as apocrine, whether in the nipple or the areola, are actually the tortuous lactiferous

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb16074.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—The activity of 14 enzymes, representative of the main metabolic pathways, was studied in the epidermis of 63 normal human subjects ranging in age from 1 month to 90 years. The activity was assayed with microfluorometric methods which allow the use of samples of epidermis very much reduced in size (0·3 μg to 1 μg). No difference of activity was observed in any of the enzymes studied despite the varied ages. The lack of influence of age on the activity of the enzymes in human epidermis enhances the significance of the variations which are reported in some pathological conditions (like psoriasis, chronic sun‐damaged skin and neop

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb16075.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—The degradation of adenosine 3′: 5′‐cyclic monophosphate (cAMP) to adenosine 5′‐monophosphate by a cutaneous phosphodiesterase has been demonstrated for the first time. The ratio of phosphodiesterase: adenyl cyclase activity in skin is the same as that found in liver and brain. Certain properties of the cutaneous enzyme have been studied; in its solubility, pH curve, Kmand sensitivity to methylxanthines it seems very similar to cAMP phosphodiesterases of other tissues.These findings suggest that the current view of cAMP as a “second messenger” in the more active tissues is equally app

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb16076.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—The activity of cAMP phosphodiesterase under conditions of substrate saturation (Vmax) and its substrate affinity (Km) were measured in biopsy specimens from the lesions of atopic dermatitis, from atopic uninvolved skin, and from the skin of healthy controls. No significant difference was found between the atopic and the control specimen

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb16077.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—The cutaneous reactions produced by the irritant compoundso‐chlorobenzylidenemalononitrile, and ω‐chloroacetophenone, have been studied on human subjects. ω‐Chloroacetophenone has been shown to present a far greater cutaneous hazard thano‐chlorobenzylidenemalononitrile when applied directly to the skin. The cutaneous reactions produced are worse when the irritant i

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb16078.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—A series of 191 male patients, 2 Kuwaitis and 189 non‐Kuwaiti immigrants from the Middle East, with cement dermatitis, is reported. On the first visit 108 patients had already passed into the chronic stage and 40% showed an irregular nummular pattern. On patch testing, all 191 patients reacted positively to 0·5% potassium dichromate but only 13 of them reacted to 5% cobalt chloride, which incriminated the chromates as the significant allergen in cement dermatitis in Kuwait. Of the 191 patients, only 16 had suffered from transient dermatitis in their countries of origin. Seventy‐seven of the remaining 175 patients came in contact with cement for the first time in Kuwait, whereas the other 88 patients had never had dermatitis in their countries of origin, in spite of long contact with cement. Of 112 patients who were followed up for a period longer than 2 years, 84 (75%) were observed to have clinical exacerbation between April and mid‐November each year. The curve describing the latter was found to be a direct function of the curve obtained for the temperature monthly means. The rising humidity during September each year overtook the high temperature, which probably provoked excessive perspiration and thus favoured the leaching of chromate ions by the in

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb16079.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—The sweat glands in the digital pads of dogs are surrounded by nerves that are clearly demonstrated with techniques for acetyl‐ and butyryl‐cholinesterase. The glands in the hairy skin have no such nerves. In the horse, despite some variation in the abundance of demonstrable nerves around the glands, the latter are surrounded by nerves that are demonstrated only with techniques for acetylcholinest

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb16080.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Summary.—A Boxer bitch aged 8 years had a chronic progressive cutaneous eruption of 5 months' duration. Histologically there was diffuse infiltration of the dermis, epidermis and adnexal structures by histiocytic cells. There was no evidence, at necropsy, of the presence of lymphosarcoma, mastocytoma, or histiocytoma.The lesions are compared with those of mycosis fungoides in ma

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1972.tb16081.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY