摘要:

SUMMARY.—The incidence of thyroid disease in patients with alopecia areata was greater than in patients with psoriasis and also greater than in a control series of the general population. There was also an increased incidence of alopecia areata and diabetes mellitus in the relatives of patients with alopecia areata. No significant difference was found in the incidence of thyroglobulin and thyroid complement‐fixing antibodies in patients with alopecia areata as compared with a general practice population. A negative association between psoriasis and thyroid antibodies was demonstra

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15967.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—When a weal evoked as a cutaneous allergic response has disappeared, that area of skin, although appearing normal, shows factitious wealing: this tendency persists for 72–96 hr. The phenomenon is present after weals caused by positive intradermal prick tests from various substances, after weals from certain insect bites, and on the site of fading lesions of acute urticaria. Weals caused by intradermal histamine are not followed by this factitious wealing, nor is it present on skin which has been the site of a weal in chronic urtica

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15968.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—The chronic polymorphic light eruptions are a miscellaneous group of cutaneous reactions in which the responsible action spectrum probably lies in the sunburn range (290 to 320 nm.) and in the long u.v. (320 to 400 nm.) and visible (above 400 nm.) ranges. A group of 25 such cases is described and details are given of the results of phototesting, using a high pressure Xenon arc light source with appropriate filters. Evidence is presented in support of the possibility that in this group there may be a specific entity which occurs most often in females, appearing for the first time usually before adult life and lasting for up to 30 to 40 years. In this group no abnormality of porphyrin metabolism can be detected. The action spectra appear to lie both within and above the sunburn range: there is some evidence to suggest that a border zone between 305 and 325 nm. may be particularly relevan

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15969.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—131 patients with hand dermatitis, 153 men and 278 women, were patch tested with an ether extract ofPrimula obconica.Four men and 16 women were found to be allergic,Primula obconicawas considered to be the cause of the present dermatitis in 4 patients and 2 of these were not aware of their allergy.Retesting with primula extract was performed in 234 persons, 76 men and 158 women, 6, 18 months after the first testing. All 12 patients who were allergic at the first testing still showed positive reactions at the second testing. In addition 23, i.e., 10°oof the patients had now become sensitized. Thus, routine testing for primula allergy is of limited clinical value in hand dermatitis and involves a great risk of test sensitizati

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15970.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—Two apocrine cystadenomas occurring on the prepuce are described. The relationship of this tumour to hidradenoma papilliferum in the female is discusse

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15971.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—Evidence is presented that the antibiotic substances sodium fusidate and fusidic acid are both capable of penetrating intact human skin at a rate similar to that seen with glucocorticoids. This is the first experimentalin vitroevidence of the penetration of a topically applied antibiotic: the techniques employed depended on the measurement of C14‐labelled material, and upon microbiological as

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15972.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—Skin and serum B:; levels were measured usingLactobacillus leishmaniiin 16 non‐psoriatic control subjects and in 10 psoriatic patients before and after treatment. There was a significant positive correlation between the B12levels of the skin and serum of the control group. The B12level was lower in psoriatic than non‐psoriatic skin and active lesions had lower levels than healed lesions. The findings suggest that the increased metabolic activity in psoriatic skin is associated with lowered B12levels which may precede visible pathological c

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15973.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—A patient is described who developed skin eruptions after both intra‐articular and oral administration of corticosteroids. Skin tests with highly purified steroid compounds were consistently and strongly positive, but an extensive series ofin vitrotests for circulating and cell‐bound steroid‐specific antibody was negative. The possible reasons for this are discussed and brief descriptions given of 2 other patients who developed generalized reactions after intra‐articular injections of corticosteroids. It is suggested that steroid hypersensitivity is an entity which ought to be considered in patients who develop unusual skin reactions during the course of steroi

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15974.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SUMMARY.—The degranulation of rat peritoneal mast cells produced by Compound 48 80, by two antigens and by hydration has been studied with the electron microscope. The different mediators of degranulation do not apparently act in the same way. Degranulation by antigens produces bizarre forms of granule and clumping of the granules, which does not occur with Compound 48/80 or hypotonic solutions. Hypotonic solutions produce swelling of cyto‐plasmic membranes but no alteration in the granules. The differences are illustrated and discus

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15975.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1969.tb15976.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY