摘要:

SUMMARYCutaneous photosensitivity is a recognized side‐effect of a number of commonly used groups of drugs, among which are the non‐steroidal anti‐inflammatory agents (NSAIDs) one of which, benoxaprofen, was withdrawn from use in 1982. The abnormal reaction of the skin to light usually occurs during the period of the systemic administration of the drug, but may with some drugs persist for longer, even for months. Chronic photosensitivity, i.e.‘persistent light reaction’ of some years duration, continuing after the withdrawal of the primary cause, has so far only been reliably reported when the initial exposure of the skin to the photoactive substance has been by external contact and not following ingestion. A suggestion that photosensitivity could persist for a period of years as a sequel of initial benoxaprofen‐induced photosensitivity was studied in a group of 42 subjects said to be affected in this way. The results failed to confirm the presence of persistent photosensitivity. It appeared that the probable explanation for the episodic abnormal reactions to light over the years since 1982 was the systemic administration of other photoactive drugs including a serie

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1989.tb08186.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

SUMMARYThe presence of natural killer (NK) cells, as defined by reactivity with the monoclonal antibodies Leu 7, Leu 11 and Leu 19 was assessed in the inflammatory infiltrate around epidermal neoplasms and compared with findings in a range of inflammatory dermatoses. HNK‐1+(Leu 7) cells were present in a wide range of malignant, pre‐malignant and inflammatory disorders. Cells positive for the more specific NK cell antigens CD16 (Leu 11)/ NKH‐1 (Leu 19) had a distribution mainly restricted to cases of squamous cell carcinoma (five of nine) and keratoacanthoma (three of seven). The variability in distribution between the different antibodies suggests that the majority of cutaneous HNK‐1+cells are not NK cells, but represent cross‐reacting T lymphocytes. The qualitatively distinct distribution of CD16+and NKH‐1+cells around some cases of squamous cell carcinoma and keratoacanthoma is of interest but their absence from a number of such cases calls into question a specific effector role for natural killer cells in these squamoproliferat

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1989.tb08187.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

SUMMARYTwenty cutaneous warts from 18 renal transplant recipients (RTR) and a single wart sample from a patient suffering from Hodgkin's disease were screened for the presence of human papillomavirus (HPV) sequences by Southern blot analysis. Thirteen samples were shown to contain HPV DNA sequences, one was identified as HPV‐3, two as HPV‐4, six as HPV‐2 and four were unidentifiable by restriction digest analysis. HPV‐3 was identified in the wart sample from the patient suffering from Hodgkin's disease. In the six samples in which HPV‐2 was found, the viral genome showed polymorphism for the PvuII and PstI sites. Two PvuII patterns and one PstI pattern

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1989.tb08188.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

SUMMARYTwo monoclonal antibodies, K20 and 4B4, assigned to the CDw29 cluster of differentiation antigens, were shown to react with basal keratinocytes (BK). The aim of this study was to identify the antigens recognized by K20 and 4B4 on epidermal cells, and to determine whether they were identical to those found on lymphocytes. Basal keratinocyte‐enriched cell suspensions were labelled with125I and then 1% NP40 cell lysates were used for immunoprecipitation. Under reducing conditions, K20 and 4B4 immunoprecipitated from basal keratinocytes a broad MW 105000 band and proteins of MW 145000, 90000 and 80000. Under non‐reducing conditions, each band was shifted down by approximately 5000 MW. Metabolic labelling studies demonstrated that the MW 145000 and 105000 subunits were synthesized by basal keratinocytes. On lymphoid cells, K20 and 4B4 are known to precipitate glycoprotein complexes made of a broad MW 130000 protein band (β subunit) associated with a protein of MW 150000 (α subunit) and proteins of MW 90000 and 80000 expressed in very low amounts. The MW 145000 and 105000 bands immunoprecipitated by K20 from basal keratinocytes correspond to the α and β subunits present on lymphoid cells. It has recently been demonstrated that K20 recognizes the common β subunit of the very late antigens family (VLA) and that 4B4 defines the helper‐inducer subset of T lymphocytes. The present investigation provides evidence that basal keratinocytes share antigens of the VLA family with lymphoid cells and that they play an important role in the immune response in the skin‐i

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1989.tb08189.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

SUMMARYThe relationship between clinical severity, the hydration state of the skin surface as assessed by a conductance with a 3.5 MHz high frequency impedance meter, and the amino acid content of the stratum corneum (SC) of six patients with ichthyosis vulgaris and 30 elderly persons with varying degrees of xerosis was investigated. With an increase in the severity of xerosis the SC showed a decrease in hydration and in its extractable amino acid content. There was a significant correlation between the hydration state and amino acid content of the SC. Although there was a significant correlation between the amino acid content of the lower leg SC and that of the forearm SC in the same subject, the former was generally lower, corresponding to the greater incidence of xerosis on the lower leg. These results suggest that a decreased amount of amino acids may be the result of low profilaggrin biosynthesis in the epidermis and that this is involved in the pathogenesis of these xerotic skin conditions. Clinical improvement of the xerosis following treatment with a urea‐containing cream was not accompanied by any significant change in the amino acid content of the S

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1989.tb08190.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

SUMMARYLarge cell anaplastic lymphoma (LCAL) is a recently described entity recognized by its constant expression of the CD30 antigen and by its morphology. LCAL is classified as high grade malignant lymphoma. We report 10 patients with LCAL of the skin, three with primary LCAL and others in which it developed with cutaneous T‐cell lymphoma, mainly mycosis fungoides. The immunophenotype in all but one of these cases, was that of activated T cell

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1989.tb08191.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

SUMMARYEight cases of adult T‐cell leukaemia/lymphoma (ATLL) with cutaneous involvement were studied. The clinical and histological features of these cases were recorded and immunohisto‐chemistry carried out using a panel of monoclonal antibodies to T‐cell differentiation antigens. Patients with ATLL showed distinct differences from patients with mycosis fungoides (MF) and Sezary syndrome (SS). Patients tended to have papulonodular and purpuric skin eruptions with pleomorphic lymphoid infiltrates, and often a degree of vasculitis. There was a high level of expression of activated T‐cell antigens, CD25, CD30, CD38, T9 an

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1989.tb08192.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

SUMMARYThe expression of plasminogen activators, plasminogen and fibrinogen was investigated in 10 specimens of normal skin and in the involved skin of seven males with Darier's disease, using immunohistochemical techniques. Changes in the localization of proteases were found in the involved skin of Darier's disease, plasminogen being expressed by suprabasal cells and fibrinogen being detected in the keratotic plug.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1989.tb08193.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

SUMMARYA study of the outcome of conventional antibiotic treatment in 543 patients with acne was performed. All were treated initially with erythromycin 1 g/day and topical 5% benzoyl peroxide. The median improvement at 6 months was 78%, with an interquartile range of 67–90%. Four‐hundred and eight of the 492 who completed 6 months'treatment showed over 50% improvement and 247 of the 279 patients treated for a subsequent 6 months with benzoyl peroxide alone, continued to do well. Another subgroup of 174 patients, was continued for 6 months with systemic antibiotic and 5% benzoyl peroxide. No significant benefit was gained, however, by maintaining successfully treated patients on a further 6 months of systemic antibiotics. Of the 84 patients who did less well, 18 were given alternative treatment (Diane®, isotretinoin). The other 60, subsequently referred to as slow responders, were continued on antibiotics (erythromycin, 31; minocin, 29; cotrimoxazole, 4; trimethoprim, 2) and benzoyl peroxide. Those prescribed minocycline for the second 6 months appeared to have greater benefit (64%) than those receiving erythromycin (57%). This level of improvement was still lower than that seen in those who responded well within 6 months (78%). Of the risk factors analysed, the poorest response occurred in males with truncal acne. Age at presentation, duration and severity did not adversely affect therapeutic outcome. Side‐effects were m

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1989.tb08194.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

SUMMARYClobetasol propionate 0.05% ointment and an otherwise identical steroid‐free base were applied topically to a 10 cm2area on the anterior thighs of six patients with symptomatic dermographism for 6 weeks. Four patients showed a significantly decreased wealing response to stroking of steroid pretreated skin compared to that of control sites. There was a parallel decrease in mast cell numbers and histamine levels in skin biopsies taken from the steroid treated areas. At 6 weeks two patients demonstrated a decrease in flare areas following the intradermal injection of compound 48/80 in steroid pretreated skin compared to base treated sites. Flare areas following intradermal injection of histamine in these two patients were equivalent in base and steroid treated ski

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1989.tb08195.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY