摘要:

SUMMARYAntibiotic‐producing bacteria were present on the healthy intact skin of 77 of 340 people but predominated in only 38.9% of these. In contrast, antibiotic‐producers which occurred in the lesions of 51 out of 263 dermatological patients predominated in 78.4%. The presence of inhibitory commensals in skin lesions was associated with a significantly low incidence of secondary infection both on admission and during hospital stay; there was, however, a small excess of Gram‐negative infections on admission in skin lesions containing antibiotic producers. Among ninety surgical patients, also, the presence of inhibitory skin bacteria was associated with a relatively low rate of wound colonization by pathogenic bacteria.The ecological implications and practical apphcations of the findings are disc

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb02241.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYThe total membrane‐bound ATP hydrolytic activity in human epidermis is due to the activities of at least three differently located enzymes, namely Mg++activated ATPase, phosphomonoesterase and adenyl cyclase.Cytochemical studies on psoriatic epidermis with various inhibitory and stimulatory substances showed reduced activities of ATPase and phosphomonoesterase, and a lack of sensitivity of adenyl cyclase to specific stimulators such as isoproterenol and glucagon. Since no differences of basal adenyl cyclase activity were observed between normal and psoriatic human skin without stimulation, it seems likely that in psoriasis a latent defect of adenyl cyelase may exist, resulting in a deficient response of this enzyme to regulatory agents.In conclusion, the present study reveals that not a single enzyme but the entire membrane‐bound nucleotide metaboHsm is altered in psoriatic keratinocytes, causing a disturbance of the membrane‐bound energy utilization, similar to findings in proliferating tumour

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb02242.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYFour distinct petide hydrolases (EC 3.4) have been characterized in guinea‐pig epidermis; these are cathepsin B13cathepsin C, cathepsin D and arylamidase. Their properties are consistent with those of lysosomal enzymes. Cathepsin E was not detecte

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb02243.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYThe clinical sign of livedo reticularis derives from stasis of blood in the superficial venous drainage systems of the skin. Many factors can delay the flow of de‐oxygenated blood away from the skin, notably hyperviscosity of the blood itself and obstruction due to disease affecting dermal arteries, capillaries, or venule

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb02244.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYDirect cutaneous immunofluorescence microscopical examination of uninvolved skin is an important diagnostic test in systemic lupus erythematosus. Its prognostic significance is undetermined. In twenty‐four patients there was an increased incidence of leukopenia, hypocomplementaemia, and LE cells in patients with positive skin immunofluorescence. Positive cutaneous immunofluorescence of uninvolved skin was correlated with the most severe forms of lupus renal disease, membranous glomerulonephritis, and diffuse proliferative glomerulonephriti

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb02245.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYCellular immune responses and circulating antibody levels to herpes simplex virus were examined in patients with recurrent herpes simplex (HSV) infections and controls.Mixed leukocyte migration inhibition by herpes simplex antigen was less in affected patients than in controls but serum antibody levels were higher.There was no significant difference in leukocyte migration between patients with active or recent lesions and other herpes subjects, and the response in the mixed leukocyte migration test to phyto‐haemagglutinin (PHA) was similar in patients and controls.The data presented suggest that a localized defect in cell mediated immunity to herpes simplex virus may exist and be responsible for recurrent herpes simplex infection

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb02246.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYThe cell‐mediated and antibody responses to human wart antigen have been studied in patients with warts and in controls. Most patients show a positive cell‐mediated response at or about the time of resolution of their warts but the detectable immunity is short‐lived. The majority of patients with warts have antibodies and the percentage rises both with resolution of the warts and with increase in the duration of the infection. No correlation between the presence of antibodies and the development of cell‐mediated immunity wa

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb02247.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYCompetence of cell‐mediated immunity in patients with warts was assessed by measuringin vitroresponse to PHA and PPD. Patients with warts were found to be less responsive as compared with a control group and this deficiency was related to the length of history of the wart infectio

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb02248.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYThe nature of a protein hapten conjugate which could effect lymphocyte transformation in nickelhypersensitivity was investigated by subjecting the culture media employed to radiochromatographicanalysis. Autoradiographic studies with63Ni demonstrate direct binding of nickel salts to the lymphocyte cell surface. This occurs with a proportion of lymphocytes both from nickel sensitive and from control subjects and so binding is not of itself the stimulus for transformation.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb02249.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

SUMMARYThirty‐one proprietary corticosteroid ointments were evaluated for vasoconstriction using an occluded blanching test. The results were expressed as three parameters: (I) area under the blanching curve, (2) summed % total possible score, and (3) square root transformation of sum of scores divided by number of volunteers. Experiments were performed to (a) compare the bio‐availability and activity of the ointments, (b) determine the effect of antimicrobial additives, and (c) assess the retention of steroids in the skin. Scores for the additive‐containing and ‘plain’ preparations were within 90% except for Locorten‐Vioform/Locorten (58%). A steroid reservoir in the skin was demonstrated lasting for 8–14 days. Selected preparations were‐re‐tested by a non‐occluded method. The results for the ointments were compared with those previously obtained using the c

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1975.tb02250.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY