摘要:

SUMMARYSerum antibodies against human papilloma virus have been measured using immunodiffusion and enzyme linked immunosorbent assay in twelve patients with epidermodysplasia verruciformis (EV). The results were compared with those from sixty‐six patients with other types of human papilloma virus diseases. Antibody prevalences were slightly lower in patients with EV than in the control patients. More remarkable was the difference between EV patients and control subjects in tests of non‐specific cell‐mediated immunity, which was markedly depressed in the majority of patients with EV, but in the main preserved in patients with common warts. No specific immunological parameter was shown to be associated with malignant conversion of EV lesions, but malignancy was linked to the character of the inducing virus, and particularly to HPV t

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb08136.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYMast cells in the upper dermis and mucosal subepithelial layer were counted in thirty consecutive light microscopy oil‐immersion fields of the following: thirty‐four skin and oral specimens from lesions in patients with active Behçet's disease, eight specimens of apparently uninvolved skin of the same patients, and 102 lesions of a variety of other skin diseases. The results revealed a significant increase in the number of mast cells in Behçet's lesions. Furthermore, the histamine content of five reactive lesions showed a two‐fold increase compared with that in apparently uninvolved skin of patients with active Behçet's disease.It is suggested that mechanisms similar to cutaneous basophil hypersensitivity may be involved in the production of Behçet'

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb08137.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYIn thirty‐four patients with porphyria cutanea tarda treated with small doses of chloroquine, liver biopsies were performed before and after treatment. In seventeen cases (50%) the morphological patterns before treatment corresponded to unstabilized fibrosis, while in eleven (32.4%) there were non‐specific changes in the form of focal fatty change, haemosiderosis, and a mild fibrosis of the portal tracts. Active chronic hepatitis was found in three patients (8.8%), and cirrhosis also in three cases.Although in all patients a clinical and metabolic remission of porphyria cutanea tarda occurred during treatment, the morphological patterns in the liver parenchyma remained on the whole unchanged. Only in five cases was there an increase in the inflammatory changes, while in two patients these changes tended to disapp

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb08138.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYUsing scanning electron microscopy it has been possible to demonstrate the location of bacteria on and within the stratum corneum of the human foot. Biopsies taken either by sectioning or by removing stratum corneum with cyanoacrylate ester adhesive were examined using a Jeol JSM‐T20 scanning electron microscope. Bacteria could be seen easily on specimens from skin which had been occluded to increase the number of bacteria present. On the surface, bacteria were scattered widely in small colonies (usually containing less than ten bacteria). Although bacteria could be seen around the orifice of sweat ducts they did not preferentially favour these sites. Within the stratum corneum, bacteria could be found as relatively large colonies but these were usually associated with sweat ducts or the underside of the furrows in the skin surface. This study suggests that, in normal skin, bacteria are able to colonize both the surface and the depths of the stratum corneu

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb08139.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYThe levels ofPropionibacterium acnes (P. acnes)and members of theMicrococcaceaewere enumerated in two separate studies. The first investigation on the foreheads of thirty‐five mild and thirty‐five moderate acne patients showed no significant difference in the bacterial populations of the two groups. The second investigation of twelve patients on 250 mg tetracycline twice daily for 3 months showed no significant difference compared to pre‐treatment data in the bacterial population during the successful treatment period.The data indicate that greater numbers of bacteria are not associated with increasing severity of acne and that the effectiveness of oral tetracycline in treating the disease can not be explained by a reduction in the number of viable bac

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb08140.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYFeulgen‐DNA cytophotometry revealed that human epidermal cell proliferation is regulated at a pre‐DNA synthetic phase and can be perturbed by mild trauma. Although uninvolved psoriatic skin appears clinically normal, its hypersensitivity indicates abnormal proliferative behaviour and may serve as a marker of latent dise

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb08141.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYBiopsies were taken from psoriatic patients undergoing photochemotherapy and then studied by autoradiography to investigate possible unscheduled DNA synthesis (UDS) following 8‐MOP photo‐damage in epidermal cells. No sparse labelling was found in seventy samples taken from twenty‐four different patients during PUVA therapy, indicating a lack of UDS. In contrast, UDS was observed in three patients irradiated with an all‐spectrum UV lamp, as a test for DNA damage and excision repair activity. The incorporation of3HTdR in these keratinocytes which were not undergoing S‐phase was not affected by the dose of UV‐A received during different stages of PUVA treatment.The results are discussed in terms of repair of the induced photodamage at the level of DNA, and in relation to a possible risk of this treatment when it is given over a long per

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb08142.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYEleven patients with severe psoriasis involving the palms and soles have been treated using a high‐energy source of UV‐A and UV‐B with no additional topical or systemic photosensitizing drug. The results showed marginal benefit of UV‐A alone over conventional topical tar therapy. The high energy output of the machine makes it essential that personnel supervising therapy are adequately pr

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb08143.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYMeasurements have been made of the spectral emission and Irradiance from whole body ultraviolet irradiation units used in the treatment of psoriasis by photochemotherapy (PUVA). A total of ten units were studied, located at nine different treatment centres in England.The results showed that within the limits of experimental accuracy there was no significant difference in the profile of all spectra measured, although the measured value of irradiance compared with each centre's own UV‐A meter showed wide discrepancies. There is poor documentation provided by manufacturers of UV‐A meters on the meaning of the scale reading in mWcm‐2, and it would seem expedient that some agreed calibration procedure for these instruments is forthc

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb08144.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYThis paper describes our experience with the use of razoxane (ICRF 159), a new anti‐mitotic drug, in the treatment of thirty‐six patients with severe psoriasis. The drug has proven highly effective both in cutaneous and in arthropathic disease. The drug is well tolerated by patients and appears to be free of hepatotoxicity. However, it causes depression of the neutrophil leukocyte count, an effect which is entirely dose‐dependent; the hazard to patients can be minimized by careful supervision of th

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1980.tb08145.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY