摘要:

SUMMARYFifty‐two patients with recurrent urticaria or angio‐oedema and thirty‐three controls have been provoked with five different food dyes and the preservatives sodium benzoate and 4‐hydroxy‐benzoic acid, as well as aspirin, sulphanilic acid and a placebo. The reaction was judged as positive in thirty‐nine patients who developed urticaria within 14 h. Of these, thirty‐five reacted to aspirin, twenty‐seven to benzoic acid compounds and twenty‐seven to azo dyes. The four patients who did not have urticaria after aspirin, reacted with urticaria to benzoic acid compounds, and three of them to azo dyes. No definite pattern for the reaction to the different azo dyes was seen. None had an urticarial reaction from sulphanilic acid, Patent Blue (a non‐azo dye) or placebo. The doses of additives used in the provocation tests are easily exceeded in daily life by the consumption of foods and drugs. Recurrences of urticaria could be prevented through the avoidance of food and drugs containing azo dye

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb08014.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYFifty cases of Gram‐negative folliculitis have been identified amongst 1200 new cases of acne vulgaris in a period of 4 years. Two clinical varieties are recognized. Type I, the more common, presents as superficial pustules, usually grouped around the nose and is associated with a lactose fermenting Gram‐negative rod. Type II lesions are characterized by deep nodular and cystic lesions;Proteusappears to be the causative agent. The treatment of this condition is discus

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb08015.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYWhen standard skin burns of mice were infected with a virulent strain ofPseudomonas aeruginosathere was rapid and extensive penetration of the burn and underlying tissues by the organisms. Under similar experimental conditions an a virulent strain ofPs. aeruginosaremained localized at the surface of the burned skin.In vitroexperiments showed that heating did not make the proteins of skin more susceptible to hydrolysis by enzymes, since heated and unheated skin were hydrolysed to approximately the same extent by proteinases from both virulent and avirulent strains ofPs. aeruginosa.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb08016.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYAll reported cases ofHætnophilus influenzæcellulitis are reviewed and compared. A typical patient is a male between the ages of 1–3 years. He is acutely ill with a red‐blue cellulitis of the face. Swelling of the involved area is massive and rapid in onset. Both temperature and the number of leukocytes are markedly elevated,Hæmophilus influenzætype B can usually be isolated from cultures of the blood or nasopharynx. Appropriate antibiotic therapy produces prompt remission of both signs and s

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb08017.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYA series of 137 patients with primary malignant melanoma of skin occurring in the Cambridge area in 1961–71 is reviewed. The histological material has been classified into lentigo maligna melanoma, superficial spreading melanoma and nodular melanoma, using the criteria of Clarket al.(1969). Consideration of type, site and incidence of melanoma when compared with previously reported series from Boston and Sydney supports the hypothesis that sunlight induces malignant melanoma in unexposed ski

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb08018.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYEnzyme histochemical tests were performed on biopsies taken from patches of lichen simplex in eighteen patients and the results were contrasted with previous findings in psoriasis and lichen planus. The mitochondria! enzyme reactions were found to be increased within the epidermis, differing from those in lichen planus, in which there is a decreased density of reaction product for these tests. The non‐specific esterase band was increased in width in lichen simplex contrasting with the absence of a discrete band in psoriasis. The DOPA reaction demonstrated the presence of positively reacting cells in the basal layer, and the ATPase reaction showed that there were many ATPase positive dendritic cells within the epidermis. It appears that in lichen simplex there is hyperplasia of all components of the epidermis in contrast to psoriasis where it seems the hyperplasia is almost restricted to keratinocyte

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb08019.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYThe principles and practice of the freeze‐fracture replication technique are outlined, and present progress relating to skin is summarized. The probable future value of the technique for the investigative dermatologist is assesse

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb08020.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYThe hydrolysis ofβ‐naphthyl acetate by plasma and by skin extracts has been investigated. In both cases the specimens from normal and atopic subjects yielded similar kinetic data.These results do not support the hypothesis of an abnormality in the enzyme acetylcholinesterase in the atop

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb08021.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYThe hydrolysis of acetylcholine by preparations of mouse and human skin has been studied. Activity has been demonstrated in both soluble and particulate fractions. In the former case at least two enzymes appear to be present; theKmvalues suggest these to be ‘true’ (3.1.1.7) and ‘pseudo’ cholinesterase (3.1‐1.8).Biopsy specimens of skin from normal and atopic subjects yielded similar kinetic data. This supports our previous conclusion that a reduced rate of hydrolysis of acetylcholine is not associated with the atopic di

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb08022.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

SUMMARYOne hundred out of 136 patients who had received either 1600 rad or more to the face, 1500 rad or more to the hands, 1600 rad or more to the finger nails, or 1600 rad or more to the feet for benign dermatoses during the years 1930 to 1964 were examined. Four patients had developed basal cell carcinomata of the face and one had developed a squamous cell carcinoma of the hands. Atrophy of the face and keratoses and telangiectasia of the hands occurred more frequently than in controls.It is concluded that superficial radiotherapy is a safe procedure for the treatment of benign dermatoses provided that no more than 1200 rad is given in fractionated doses to any area of skin over a lifetime. Recommendations are put forward to ensure that damage does not result from radiation.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1973.tb08023.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY