摘要:

SUMMARYEight patients are reported who all have one feature in common, the appearance of premature ageing. Six of these could be accurately classified into previously described syndromes, but the other two may represent a new syndrome which we have called metageria. Clinical and other features of these two individuals are compared with three patients with acrogeria (Gottron's syndrome), one with pangeria (Werner's syndrome), one with progeria (Hutchinson‐Gilford syndrome) and one with a total lipodystrophy (Lawrence's syndrome

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb12893.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYNinety‐one cases of papulonecrotic tuberculide were seen by the Department of Dermatology during the past 17 years. A focus of tuberculosis was found in 38%. Associated clinical phenomena included tuberculous arteritis with gangrene and the development of lupus vulgaris from papulonecrotic tuberculides. It is suggested that these tuberculides begin as an Arthus reaction which is followed by a delayed hypersensitivity response. The latter will prevent local proliferation ofMycobacterium tuberculosisin most cases, but in rare cases local multiplication of the organisms may lead to the development of lupus vulgaris. All patients improved rapidly on antituberculous treatmen

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb12894.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYExisting techniques have been modified to enable the estimation of DNA in skin washings from cattle. The technique evolved is described including the separation of a naturally occurring fluorescent substance in the skin washings.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb12895.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYA method for culturing monolayers of cells from psoriatic lesions is described. Cultures have been maintained for 3 to 8 weeks. Apart from keratinocytes, melanocytes and non‐pigmented dendritic cells, two types of cell were observed which are not commonly seen in normal skin, viz. a cell with a basket weave type of cytoplasm and a cell with a very long, up to 500 μm, cytoplasmic extensi

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb12896.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYBiopsy material from ninety‐one cases of inflammatory facial dermatoses was stained by the direct immunofluorescence method. The presence of immunoglobulins and complement in a distinct basement membrane band was seen only in lupus erythematosus. Negative results were found in thirty five cases of rosace

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb12897.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYThe electron microscopic study of six cases of chronic radiodermatitis from sun‐exposed and unexposed skin, confirms the observation of elastosis previously described with light microscopy. The pathological findings are comparable with those found in actinic elastosis; increased width of the fibres, irregularity of their shape, increased density and granularity of the microfibrils and holes with many lobes in the matrix.The findings may be due to transformation of elastic fibres into elastotic fibres or the formation of dystrophic elastotic fibres by dermal fibroblast

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb12898.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYIn a study of the black tissue grains formed in mycetoma caused byMadurella mycetomi, the evidence pointed to a tanned protein or melanoprotein as the main durable constituent of the grain cement. It appeared likely that the melanizing agent arose from the fungus, while the protein component came from the host. Resistance to treatment was considered to depend on the impenetrability of the cement so produced.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb12899.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYA common abnormality of the veins of the fingers in elderly persons, with characteristic clinical features, is described. A survey shows that this is an age related condition. There was little evidence of an association with other abnormalities of the veins elsewhere. Histological findings were of dilated veins with thickened walls, and of larger circular thin walled lesions which were occasionally thrombosed.Approximately half of the subjects surveyed showed evidence of these changes and there were no differences by sex. It seems that these lesions are properly included in the classification of the ageing phlebectasias and possible factors in their production are discussed.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb12900.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYThe lymphocyte eluates of three patients with discoid lupus erythematosus and two patients with pemphigoid possessed basement membrane antibody of the IgG class either for normal human skin or guinea‐pig lip.The lymphocyte eluates from one patient with pemphigus did contain antibody (IgG) reactive with the intercellular substances of monkey oesophagus, and that of a patient with a drug reaction showed antibody reactive with basal cells of stratified epithehum.These results indicate either antibody synthesis by the lymphocytes themselves, or that these cells may provide antigenic receptors reactive with specific antibod

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb12901.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

SUMMARYThirteen cases of pityriasis lichenoides were treated with oral tetracycline. Five of them were completely cured, another seven had to continue to take 1 g/day. Addition of an antihistamine in one patient who did not respond to tetracycline gave a dramatic result. Throat swab cultures yielded coagulase positive staphylococci in four cases and other kinds of bacteria in many other cases. Based on the results of the treatment and histological findings, it is postulated that the pathogenesis of pityriasis lichenoides may be due to a hypersensitivity reaction to infectious agents.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1974.tb12902.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY