ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb04059.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SUMMARYAnin vitrostudy of the oxidation of squalene, and a description of factors acting on this transformation are presented. Thin layer chromatography was used to quantify the products generated by different oxidation processes. The results clearly show that squalene is a highly effective oxygen‐scavenging agent. Its oxidation may first induce comedogenesis and, as a secondary event, cause a large reduction in oxygen tension in the human pilo‐sebaceous duct. Porphyrins were confirmed to be highly efficient catalytic factors in the squalene oxidation process. The relationships between comedogenesis, bacterial colonization, and the role of sebum in the pathogenesis of acne are discussed in the light of these findi

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb04060.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SUMMARYSkin surface lipids and lipids from open and closed comedones in acne patients were analysed by thin layer chromatography. The results showed that these lipids were enriched in polar lipids, as compared with the skin surface lipids obtained from controls without acne. In both open and closed comedones, these polar lipids appeared to be derived mainly from the oxidation of squalene, which is in agreement with our previousin vitroresults.We suggest that squalene oxidation is the link between comedogenesis and bacterial colonization, and based on this, we propose a hypothesis of the pathogenesis of acne.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb04061.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SUMMARYThe metabolism of arachidonic acid by mixed suspensions of leukocytes and platelets prepared from peripheral blood has been studied in 20 patients with psoriasis and 21 healthy controls. A lipoxygenase‐derived product, identified as 12,20‐dihydroxy‐5,8,10,14‐eicosatetraenoic acid was formed in increased amounts by the cell suspensions from the psoriatic patients. This product results from the metabolism of platelet‐derived 12‐hydroxy‐5,8,10,14‐eicosatetraenoic acid by the polymorphonuclear leukocyte 20‐hydroxylase enzyme. By contrast, synthesis of the cyclo‐oxygenase products 12‐hydroxy‐5,8,10‐heptadecatrienoic acid and thromboxane B2was diminished. Benoxaprofen, which is known to be beneficial in psoriasis, diminished the levels of 12,20‐dihydroxy‐5,8,10,14‐eicos

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb04062.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SUMMARYWe have measured C3, C4, CH50and complement cleavage products C3a and C5a in sera and plasma from PCT patients and normal controls 10 min and I, 4 and 24 h after UVA irradiation.We found elevated C3a concentrations in PCT patients immediately after UVA irradiation and 24 h later. The same was true for CH50, whereas C3, C4and C5a did not change significantly. No such changes occurred in normal controls.Our data suggest that activation of the complement cleavage product C3a by porphyrin and UV light triggers a series of events that cause tissue damage.

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb04063.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SUMMARYHistories of recurrent infections were obtained from 955 adults with past or present atopic dermatitis (AD) and from 199 controls. Patients who had previously been hospitalized in childhood because of severe AD had a significantly higher incidence of recurrent (>5 episodes per year) cold sores and upper respiratory tract infections as well as a higher incidence of herpes zoster, than non‐atopic controls. Patients with milder AD in childhood (never hospitalized) had lower incidence of these diseases, but as regards cold sores, the frequency of recurrent infections was still significantly higher than that of the controls. AD patients with past or present respiratory allergy had a slight but not statistically significant increased incidence of recurrent infections, as compared to AD patients without concomitant respiratory allergy. The factors predisposing to frequent infections appeared to be those related to severity of the atopic condition, i.e. ongoing AD, need for hospitalization in childhood and extent of dermatitis. The increased susceptibility to recurrent viral infections in AD patients is most probably related to dysfunctioning cell‐mediated immun

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb04064.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SUMMARYSeven of twelve autologous sera from patients with chronic idiopathic urticaria re‐injected intradermally produced a weal at the site of injection. There was no response in 19 control subjects. Patients showing a positive response had a shorter duration of disease and shorter duration of spontaneous weals, and their urticaria was less likely to be exacerbated by pressure. There was some serological evidence of circulating immune complexes in both positive and negative responders to autologous serum, but only two showed complement abnormalities. When six of the serum‐positive patients were re‐tested after one year, five still showed a positive response with their original stored serum, but only two, whose disease remained active, were positive when challenged with freshly drawn serum, suggesting that a serum mediator is only present when the urticaria is active. A marked neutrophil infiltrate was seen within and around small dermal blood vessels at the injection site in the majority of urticaria patients but this appearance did not correlate with weal formation. In control subjects the cellular response was mild and mainly mononu

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb04065.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SUMMARYThe structure of hairs from three patients with sulphur‐deficient hair, trichothiodystrophy, has been studies by light, plane‐polarizing and scanning electron microscopy. Severe cuticular and secondary cortical degeneration was evident along almost the entire length of the hair shaft, with cuticle loss, trichorrhexis nodosa formation and trichoschisis. The severity of these changes varied between patients. The role of the cuticle in protecting hair from environmental damage is discus

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb04066.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SUMMARYTwo patients with schistosomiasis of the skin were seen at the Ahmadu Bello University Teaching Hospital, Kaduna, Northern Nigeria, between June 1978 and December 1980. The first case was not suspected on clinical grounds, but was diagnosed only after terminally‐spined ova ofSchistosoma haematobiumwere found in histological sections of the skin lesions. Both patients were successfully treated with niridazole (Ambilhar®). These bring to eight the total number of cases of cutaneous schistosomiasis recorded in Nigeria in the past 40 years, four of which were in indigenous Nigerians. It seems that the high endemicity of the disease confers some degree of natural immunity to the indigenous population, making ectopic forms rare. Clinicians should be aware of the existence of cutaneous forms of the disease and of their excellent response to specific chemothera

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb04067.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SUMMARYUsing an infrared coagulator, we have shown, in pigskin, a direct relationship between depth of injury and the duration of infra‐red pulses, which was highly reproducible at a particular site. This has been related to the clinical results achieved in one patient whose three tattoos were treated with different pulse time

ISSN:0007-0963    

DOI:10.1111/j.1365-2133.1986.tb04068.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY